SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

SIGNATUREFD, LLC's Holding History (CIK: 0001456048)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 70 Value ($000) $2 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 70 Value ($000) $1 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 165 Value ($000) $2 Avg Close $14.80 Range $10.91 - $19.20

Q4 2024

Shares 68 Value ($000) $2 Avg Close $29.32 Range $22.37 - $40.26

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	70	$2	$26.13	$15.86 - $35.31
Q3 2025	70	$1	$16.31	$14.00 - $18.30
Q2 2025	165	$2	$14.80	$10.91 - $19.20
Q4 2024	68	$2	$29.32	$22.37 - $40.26