SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

RTW INVESTMENTS, LP's Holding History (CIK: 0001493215)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 4,171,996 Value ($000) $136,675 Avg Close $26.13 Range $15.86 - $35.31
Q3 2025
Shares 3,621,996 Value ($000) $60,705 Avg Close $16.31 Range $14.00 - $18.30
Q2 2025
Shares 3,621,996 Value ($000) $54,221 Avg Close $14.80 Range $10.91 - $19.20
Q1 2025
Shares 3,621,996 Value ($000) $58,441 Avg Close $20.81 Range $16.13 - $26.01
Q4 2024
Shares 3,621,996 Value ($000) $84,320 Avg Close $29.32 Range $22.37 - $40.26
Q3 2024
Shares 3,258,360 Value ($000) $95,828 Avg Close $27.85 Range $23.00 - $32.41
Q2 2024
Shares 3,258,360 Value ($000) $76,604 Avg Close $33.73 Range $22.19 - $40.84
Q1 2024
Shares 2,232,760 Value ($000) $84,689 Avg Close $28.97 Range $18.54 - $47.97
Q4 2023
Shares 2,232,760 Value ($000) $48,049 Avg Close $13.78 Range $8.43 - $22.66