SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

EcoR1 Capital, LLC's Holding History (CIK: 0001587114)

Note: Option positions (PUT/CALL) are excluded.

Q4 2023

Shares 887,076 Value ($000) $19,090 Avg Close $13.78 Range $8.43 - $22.66

Q3 2023

Shares 199,996 Value ($000) $2,450 Avg Close $13.22 Range $9.53 - $18.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2023	887,076	$19,090	$13.78	$8.43 - $22.66
Q3 2023	199,996	$2,450	$13.22	$9.53 - $18.00