SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 65,000 Value ($000) $1,089 Avg Close $16.31 Range $14.00 - $18.30

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	65,000	$1,089	$16.31	$14.00 - $18.30