SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Squarepoint Ops LLC's Holding History (CIK: 0001642575)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 20,232 Value ($000) $339 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 30,046 Value ($000) $450 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 72,011 Value ($000) $1,162 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 15,231 Value ($000) $355 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 8,477 Value ($000) $249 Avg Close $27.85 Range $23.00 - $32.41

Q1 2024

Shares 8,161 Value ($000) $310 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	20,232	$339	$16.31	$14.00 - $18.30
Q2 2025	30,046	$450	$14.80	$10.91 - $19.20
Q1 2025	72,011	$1,162	$20.81	$16.13 - $26.01
Q4 2024	15,231	$355	$29.32	$22.37 - $40.26
Q3 2024	8,477	$249	$27.85	$23.00 - $32.41
Q1 2024	8,161	$310	$28.97	$18.54 - $47.97