SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 818,598 Value ($000) $26,817 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 368,598 Value ($000) $6,178 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 368,598 Value ($000) $5,518 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 368,598 Value ($000) $5,947 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 374,000 Value ($000) $8,707 Avg Close $29.32 Range $22.37 - $40.26

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	818,598	$26,817	$26.13	$15.86 - $35.31
Q3 2025	368,598	$6,178	$16.31	$14.00 - $18.30
Q2 2025	368,598	$5,518	$14.80	$10.91 - $19.20
Q1 2025	368,598	$5,947	$20.81	$16.13 - $26.01
Q4 2024	374,000	$8,707	$29.32	$22.37 - $40.26