Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
PBLS	Parabilis Medicines Inc	2,992,259	$81.9M	1.7%	$27.37	—	COM	698955101
ABVX	Abivax SA	576,000	$76.76M	1.6%	$133.26	—	SPONSORED ADS	00370M103
COAG	Hemab Therapeutics Holdings Inc	2,086,834	$76.65M	1.6%	$36.73	—	COM SHS	423494103
RLAY	Relay Therapeutics Inc	3,650,000	$68.29M	1.4%	$18.71	—	COM	75943R102
KLRA	Kailera Therapeutics Inc	2,214,286	$48.78M	1.0%	$22.03	—	COMMON STOCK	482931102
COF	Capital One Finl Corp	171,615	$34.43M	0.7%	$200.62	—	COM	14040H105
ORKA	Oruka Therapeutics Inc	250,000	$23.79M	0.5%	$95.17	—	COM	687604108
SPTX	Seaport Therapeutics Inc	1,095,316	$23.79M	0.5%	$21.72	—	COMMON STOCK	81221K108
TYRA	Tyra Biosciences Inc	725,000	$23.16M	0.5%	$31.94	—	COM	90240B106
ADAG	Adagene Inc	2,666,666	$11.2M	0.2%	$4.20	—	ADS	005329107
ENGN	enGene Therapeutics Inc	6,256,662	$10.82M	0.2%	$1.73	—	COM	29286X101
MSFT	Microsoft Corp	24,000	$8.952M	0.2%	$431.05	—	CALL	594918104
OCS	Oculis Holding AG	625,000	$8.669M	0.2%	$13.87	—	ORDINARY SHARES	H5870P102
DSGN	Design Therapeutics Inc	523,212	$7.571M	0.2%	$14.47	—	COM	25056L103
AAPL	Apple Inc	23,000	$6.655M	0.1%	—	—	CALL	037833100
ELOX	Eloxx Pharmaceuticals Inc	400,000	$5.552M	0.1%	$13.88	—	COM NEW	29014R301
BABA	Alibaba Group Holding Ltd	50,000	$4.799M	0.1%	$95.98	—	SPONSORED ADS	01609W102
OUST	Ouster Inc	67,500	$4.22M	0.1%	$62.52	—	COM NEW	68989M202
PALI	Palisade Bio Inc	2,000,000	$4.18M	0.1%	$2.09	—	COM	696389402
ODTX	Odyssey Therapeutics Inc	200,000	$3.742M	0.1%	$18.71	—	COMMON STOCK	67613T104
ZTS	Zoetis Inc	35,000	$2.515M	0.1%	$71.86	—	CL A	98978V103
NFLX	Netflix Inc	25,000	$1.785M	0.0%	$71.40	—	COM	64110L106
QNT	Quantinuum Inc	20,000	$1.635M	0.0%	$81.74	—	CL A COM	74768A104
ENTX	Entera Bio Ltd	736,457	$1.304M	0.0%	$1.77	—	SHS	M40527109
LITE	Lumentum Holdings Inc	1,055	$905K	0.0%	$858.06	—	COM	55024U109
FOXA	Fox Corp	10,000	$522K	0.0%	$52.16	—	CL A COM	35137L105
T	AT&T Inc	25,000	$518K	0.0%	$20.70	—	COM	00206R102

Increased Positions (31)

MANE Veradermics Inc 4.1%

Value $204M (+114.1%) Shares 1,655,374 (+10.0%) Est. Cost $68.57 Unrealized —

TNGX Tango Therapeutics Inc 3.9%

Value $193M (+63.2%) Shares 6,179,364 (+9.2%) Est. Cost $9.72 Unrealized —

RYTM Rhythm Pharmaceuticals Inc 2.6%

Value $126M (+99.9%) Shares 1,136,275 (+56.6%) Est. Cost $88.60 Unrealized —

ELVN Enliven Therapeutics Inc 1.8%

Value $90.05M (+207.8%) Shares 1,774,411 (+137.8%) Est. Cost $40.18 Unrealized —

DFTX Definium Therapeutics Inc 1.4%

Value $66.77M (+284.2%) Shares 1,419,493 (+54.4%) Est. Cost $27.12 Unrealized —

SYRE Spyre Therapeutics Inc 1.7%

Value $85.99M (+108.3%) Shares 968,598 (+18.3%) Est. Cost $37.05 Unrealized —

ARWR Arrowhead Pharmaceuticals Inc 2.8%

Value $140M (+38.0%) Shares 1,715,476 (+6.2%) Est. Cost $30.00 Unrealized —

TSHA Taysha Gene Therapies Inc 1.4%

Value $67.06M (+69.9%) Shares 9,846,579 (+11.5%) Est. Cost $2.65 Unrealized —

ERAS Erasca Inc 4.2%

Value $209M (+14.8%) Shares 11,397,781 (+1.4%) Est. Cost $4.60 Unrealized —

CYTK Cytokinetics Inc 1.3%

Value $64.66M (+59.8%) Shares 758,952 (+23.6%) Est. Cost $68.41 Unrealized —

ABSI Absci Corp 0.6%

Value $28.68M (+431.2%) Shares 2,474,764 (+37.5%) Est. Cost $5.34 Unrealized —

SLN Silence Therapeutics PLC 0.7%

Value $36.36M (+137.0%) Shares 3,311,438 (+13.7%) Est. Cost $16.86 Unrealized —

CGEM Cullinan Therapeutics Inc 0.7%

Value $34.48M (+103.3%) Shares 1,893,410 (+58.7%) Est. Cost $17.91 Unrealized —

SION Sionna Therapeutics Inc 0.5%

Value $26.86M (+123.3%) Shares 610,515 (+103.5%) Est. Cost $30.40 Unrealized —

GOOGL Alphabet Inc 0.7%

Value $32.16M (+70.2%) Shares 90,000 (+37.0%) Est. Cost $299.25 Unrealized —

OLMA Olema Pharmaceuticals Inc 1.2%

Value $60.76M (-14.3%) Shares 4,856,949 (+2.1%) Est. Cost $19.98 Unrealized —

AMLX Amylyx Pharmaceuticals Inc 0.5%

Value $26.59M (+55.5%) Shares 1,480,586 (+20.4%) Est. Cost $14.66 Unrealized —

TSM Taiwan Semiconductor Manufacturing Co Ltd 0.4%

Value $21.35M (+49.7%) Shares 44,700 (+5.9%) Est. Cost $244.00 Unrealized —

IREN IREN Ltd 0.2%

Value $8.003M (+441.7%) Shares 175,000 (+306.0%) Est. Cost $44.05 Unrealized —

COGT Cogent Biosciences Inc 1.5%

Value $71.95M (+9.4%) Shares 1,859,279 (+8.8%) Est. Cost $12.37 Unrealized —

AVGO Broadcom Inc 0.2%

Value $9.444M (+103.4%) Shares 25,000 (+66.7%) Est. Cost $357.99 Unrealized —

ANNX Annexon Inc 0.5%

Value $25.46M (+16.1%) Shares 4,458,646 (+12.6%) Est. Cost $5.74 Unrealized —

WHWK Whitehawk Therapeutics Inc 0.2%

Value $10.7M (+49.0%) Shares 2,337,102 (+12.3%) Est. Cost $2.83 Unrealized —

NVDA NVIDIA Corp 0.4%

Value $19.01M (+22.3%) Shares 95,000 (+6.6%) Est. Cost $160.76 Unrealized —

AEVA Aeva Technologies Inc 0.1%

Value $4.178M (+188.6%) Shares 145,459 (+32.2%) Est. Cost $18.36 Unrealized —

GTLB GitLab Inc 0.1%

Value $3.816M (+76.4%) Shares 125,000 (+25.0%) Est. Cost $41.91 Unrealized —

MNDY monday.com Ltd 0.1%

Value $3.077M (+78.1%) Shares 42,500 (+70.0%) Est. Cost $127.95 Unrealized —

PDD PDD Holdings Inc 0.1%

Value $7.247M (-15.0%) Shares 95,000 (+13.9%) Est. Cost $112.20 Unrealized —

DT Dynatrace, Inc 0.1%

Value $6.806M (+22.7%) Shares 155,000 (+3.3%) Est. Cost $46.01 Unrealized —

IVVD Invivyd Inc 0.1%

Value $4.362M (-16.1%) Shares 5,000,000 (+25.0%) Est. Cost $1.84 Unrealized —

NOW ServiceNow Inc 0.2%

Value $9.928M (+9.0%) Shares 100,000 (+14.8%) Est. Cost $136.80 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
MANE	Veradermics Inc	1,655,374 (+10.0%)	$204M (+114.1%)	4.1%	$68.57	—	COMMON STOCK	922967104
TNGX	Tango Therapeutics Inc	6,179,364 (+9.2%)	$193M (+63.2%)	3.9%	$9.72	—	COM	87583X109
RYTM	Rhythm Pharmaceuticals Inc	1,136,275 (+56.6%)	$126M (+99.9%)	2.6%	$88.60	—	COM	76243J105
ELVN	Enliven Therapeutics Inc	1,774,411 (+137.8%)	$90.05M (+207.8%)	1.8%	$40.18	—	COM	29337E102
DFTX	Definium Therapeutics Inc	1,419,493 (+54.4%)	$66.77M (+284.2%)	1.4%	$27.12	—	COM SHS	24477V105
SYRE	Spyre Therapeutics Inc	968,598 (+18.3%)	$85.99M (+108.3%)	1.7%	$37.05	—	COM NEW	00773J202
ARWR	Arrowhead Pharmaceuticals Inc	1,715,476 (+6.2%)	$140M (+38.0%)	2.8%	$30.00	—	COM	04280A100
TSHA	Taysha Gene Therapies Inc	9,846,579 (+11.5%)	$67.06M (+69.9%)	1.4%	$2.65	—	COM SHS	877619106
ERAS	Erasca Inc	11,397,781 (+1.4%)	$209M (+14.8%)	4.2%	$4.60	—	COM	29479A108
CYTK	Cytokinetics Inc	758,952 (+23.6%)	$64.66M (+59.8%)	1.3%	$68.41	—	COM NEW	23282W605
ABSI	Absci Corp	2,474,764 (+37.5%)	$28.68M (+431.2%)	0.6%	$5.34	—	COM	00091E109
SLN	Silence Therapeutics PLC	3,311,438 (+13.7%)	$36.36M (+137.0%)	0.7%	$16.86	—	ADS	82686Q101
CGEM	Cullinan Therapeutics Inc	1,893,410 (+58.7%)	$34.48M (+103.3%)	0.7%	$17.91	—	COM	230031106
SION	Sionna Therapeutics Inc	610,515 (+103.5%)	$26.86M (+123.3%)	0.5%	$30.40	—	COM	829401108
GOOGL	Alphabet Inc	90,000 (+37.0%)	$32.16M (+70.2%)	0.7%	$299.25	—	CAP STK CL A	02079K305
OLMA	Olema Pharmaceuticals Inc	4,856,949 (+2.1%)	$60.76M (-14.3%)	1.2%	$19.98	—	COM	68062P106
AMLX	Amylyx Pharmaceuticals Inc	1,480,586 (+20.4%)	$26.59M (+55.5%)	0.5%	$14.66	—	COM	03237H101
TSM	Taiwan Semiconductor Manufacturing Co Ltd	44,700 (+5.9%)	$21.35M (+49.7%)	0.4%	$244.00	—	SPONSORED ADS	874039100
IREN	IREN Ltd	175,000 (+306.0%)	$8.003M (+441.7%)	0.2%	$44.05	—	ORDINARY SHARES	Q4982L109
COGT	Cogent Biosciences Inc	1,859,279 (+8.8%)	$71.95M (+9.4%)	1.5%	$12.37	—	COM	19240Q201
AVGO	Broadcom Inc	25,000 (+66.7%)	$9.444M (+103.4%)	0.2%	$357.99	—	COM	11135F101
ANNX	Annexon Inc	4,458,646 (+12.6%)	$25.46M (+16.1%)	0.5%	$5.74	—	COM	03589W102
WHWK	Whitehawk Therapeutics Inc	2,337,102 (+12.3%)	$10.7M (+49.0%)	0.2%	$2.83	—	COM	00032Q104
NVDA	NVIDIA Corp	95,000 (+6.6%)	$19.01M (+22.3%)	0.4%	$160.76	—	COM	67066G104
AEVA	Aeva Technologies Inc	145,459 (+32.2%)	$4.178M (+188.6%)	0.1%	$18.36	—	COM NEW	00835Q202
GTLB	GitLab Inc	125,000 (+25.0%)	$3.816M (+76.4%)	0.1%	$41.91	—	CLASS A COM	37637K108
MNDY	monday.com Ltd	42,500 (+70.0%)	$3.077M (+78.1%)	0.1%	$127.95	—	SHS	M7S64H106
PDD	PDD Holdings Inc	95,000 (+13.9%)	$7.247M (-15.0%)	0.1%	$112.20	—	SPONSORED ADS	722304102
DT	Dynatrace, Inc	155,000 (+3.3%)	$6.806M (+22.7%)	0.1%	$46.01	—	COM NEW	268150109
IVVD	Invivyd Inc	5,000,000 (+25.0%)	$4.362M (-16.1%)	0.1%	$1.84	—	COM	00534A102
NOW	ServiceNow Inc	100,000 (+14.8%)	$9.928M (+9.0%)	0.2%	$136.80	—	COM	81762P102

Exited Positions (10)

CNTA Centessa Pharmaceuticals PLC 0.8%

Value $41.84M Shares 1,053,464 Est. Cost $17.45 Unrealized —

ENGN enGene Holdings Inc 0.7%

Value $35.77M Shares 5,253,159 Est. Cost $8.61 Unrealized —

FULC Fulcrum Therapeutics Inc 0.4%

Value $18.02M Shares 2,350,000 Est. Cost $10.21 Unrealized —

WVE WAVE Life Sciences Ltd 0.4%

Value $17.76M Shares 2,450,000 Est. Cost $5.98 Unrealized —

QURE Uniqure NV 0.3%

Value $16.35M Shares 1,000,000 Est. Cost $23.55 Unrealized —

BCYC Bicycle Therapeutics PLC 0.1%

Value $7.242M Shares 1,560,882 Est. Cost $13.30 Unrealized —

FPS Forgent Power Solutions, Inc 0.1%

Value $2.927M Shares 100,000 Est. Cost $29.27 Unrealized —

MU Micron Technology Inc 0.0%

Value $2.027M Shares 6,000 Est. Cost $387.04 Unrealized —

AS Amer Sports Inc 0.0%

Value $1.646M Shares 50,000 Est. Cost $38.20 Unrealized —

PRMB Primo Brands Corp 0.0%

Value $942K Shares 50,000 Est. Cost $28.92 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
CNTA	Centessa Pharmaceuticals PLC	1,053,464	$41.84M	0.8%	$17.45	—	—	152309100
ENGN	enGene Holdings Inc	5,253,159	$35.77M	0.7%	$8.61	—	—	29286M105
FULC	Fulcrum Therapeutics Inc	2,350,000	$18.02M	0.4%	$10.21	—	—	359616109
WVE	WAVE Life Sciences Ltd	2,450,000	$17.76M	0.4%	$5.98	—	—	Y95308105
QURE	Uniqure NV	1,000,000	$16.35M	0.3%	$23.55	—	—	N90064101
BCYC	Bicycle Therapeutics PLC	1,560,882	$7.242M	0.1%	$13.30	—	—	088786108
FPS	Forgent Power Solutions, Inc	100,000	$2.927M	0.1%	$29.27	—	—	34631F102
MU	Micron Technology Inc	6,000	$2.027M	0.0%	$387.04	—	—	595112103
AS	Amer Sports Inc	50,000	$1.646M	0.0%	$38.20	—	—	G0260P102
PRMB	Primo Brands Corp	50,000	$942K	0.0%	$28.92	—	—	741623102

Decreased Positions (21)

KYMR Kymera Therapeutics Inc 6.8%

Value $337M (+26.8%) Shares 2,935,830 (-7.9%) Est. Cost $43.02 Unrealized —

RVMD Revolution Medicines Inc 3.4%

Value $169M (+56.0%) Shares 900,000 (-19.0%) Est. Cost $46.57 Unrealized —

BCAX Bicara Therapeutics Inc 3.4%

Value $166M (+44.1%) Shares 5,602,970 (-3.4%) Est. Cost $19.85 Unrealized —

GPCR Structure Therapeutics Inc 0.9%

Value $46.85M (-26.8%) Shares 872,967 (-34.3%) Est. Cost $33.42 Unrealized —

CRNX Crinetics Pharmaceuticals Inc 1.1%

Value $53.17M (-23.1%) Shares 1,420,788 (-25.4%) Est. Cost $51.17 Unrealized —

SEPN Septerna Inc 1.3%

Value $63.63M (+32.4%) Shares 1,900,000 (-5.0%) Est. Cost $23.65 Unrealized —

TBLA Taboola.com Ltd 0.9%

Value $42.12M (+36.3%) Shares 8,423,410 (-15.5%) Est. Cost $3.30 Unrealized —

EWTX Edgewise Therapeutics Inc 2.6%

Value $129M (-7.3%) Shares 3,184,629 (-28.1%) Est. Cost $19.44 Unrealized —

RCUS Arcus Biosciences Inc 1.5%

Value $74.62M (+14.9%) Shares 2,420,430 (-19.5%) Est. Cost $13.59 Unrealized —

DYN Dyne Therapeutics, Inc 1.0%

Value $47.29M (+17.0%) Shares 2,129,125 (-4.5%) Est. Cost $19.51 Unrealized —

TSLA Tesla Inc 0.0%

Value $1.472M (-81.6%) Shares 3,500 (-83.7%) Est. Cost $419.51 Unrealized —

SRRK Scholar Rock Holding Corp 10.7%

Value $527M (-1.0%) Shares 9,575,013 (-11.5%) Est. Cost $12.96 Unrealized —

DDOG Datadog Inc 0.2%

Value $10.41M (+62.5%) Shares 40,000 (-26.3%) Est. Cost $123.86 Unrealized —

NBP NovaBridge Biosciences 0.1%

Value $3.909M (-47.0%) Shares 2,004,739 (-33.2%) Est. Cost $3.90 Unrealized —

WK Workiva Inc 0.0%

Value $2.183M (-60.4%) Shares 45,000 (-51.4%) Est. Cost $84.89 Unrealized —

FROG Jfrog Ltd 0.2%

Value $8.679M (+43.6%) Shares 95,500 (-25.9%) Est. Cost $37.17 Unrealized —

NBIS Nebius Group NV 0.3%

Value $14.36M (+21.8%) Shares 52,000 (-54.2%) Est. Cost $59.72 Unrealized —

AMZN Amazon.com Inc 0.2%

Value $7.746M (-20.3%) Shares 32,500 (-30.3%) Est. Cost $196.43 Unrealized —

IRON Disc Medicine Inc 1.3%

Value $64.98M (+2.8%) Shares 888,401 (-10.1%) Est. Cost $57.60 Unrealized —

CRWD CrowdStrike Holdings Inc 0.2%

Value $7.631M (-15.3%) Shares 10,000 (-56.7%) Est. Cost $328.72 Unrealized —

MSFT Microsoft Corp 0.3%

Value $13.99M (-8.7%) Shares 37,500 (-9.4%) Est. Cost $431.05 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
KYMR	Kymera Therapeutics Inc	2,935,830 (-7.9%)	$337M (+26.8%)	6.8%	$43.02	—	COM	501575104
RVMD	Revolution Medicines Inc	900,000 (-19.0%)	$169M (+56.0%)	3.4%	$46.57	—	COM	76155X100
BCAX	Bicara Therapeutics Inc	5,602,970 (-3.4%)	$166M (+44.1%)	3.4%	$19.85	—	COM	055477103
GPCR	Structure Therapeutics Inc	872,967 (-34.3%)	$46.85M (-26.8%)	0.9%	$33.42	—	SPONSORED ADS	86366E106
CRNX	Crinetics Pharmaceuticals Inc	1,420,788 (-25.4%)	$53.17M (-23.1%)	1.1%	$51.17	—	COM	22663K107
SEPN	Septerna Inc	1,900,000 (-5.0%)	$63.63M (+32.4%)	1.3%	$23.65	—	COM	81734D104
TBLA	Taboola.com Ltd	8,423,410 (-15.5%)	$42.12M (+36.3%)	0.9%	$3.30	—	ORD SHS	M8744T106
EWTX	Edgewise Therapeutics Inc	3,184,629 (-28.1%)	$129M (-7.3%)	2.6%	$19.44	—	COM	28036F105
RCUS	Arcus Biosciences Inc	2,420,430 (-19.5%)	$74.62M (+14.9%)	1.5%	$13.59	—	COM	03969F109
DYN	Dyne Therapeutics, Inc	2,129,125 (-4.5%)	$47.29M (+17.0%)	1.0%	$19.51	—	COM	26818M108
TSLA	Tesla Inc	3,500 (-83.7%)	$1.472M (-81.6%)	0.0%	$419.51	—	COM	88160R101
SRRK	Scholar Rock Holding Corp	9,575,013 (-11.5%)	$527M (-1.0%)	10.7%	$12.96	—	COM	80706P103
DDOG	Datadog Inc	40,000 (-26.3%)	$10.41M (+62.5%)	0.2%	$123.86	—	CL A COM	23804L103
NBP	NovaBridge Biosciences	2,004,739 (-33.2%)	$3.909M (-47.0%)	0.1%	$3.90	—	SPONSORED ADS	44975P103
WK	Workiva Inc	45,000 (-51.4%)	$2.183M (-60.4%)	0.0%	$84.89	—	COM CL A	98139A105
FROG	Jfrog Ltd	95,500 (-25.9%)	$8.679M (+43.6%)	0.2%	$37.17	—	ORD SHS	M6191J100
NBIS	Nebius Group NV	52,000 (-54.2%)	$14.36M (+21.8%)	0.3%	$59.72	—	SHS CLASS A	N97284108
AMZN	Amazon.com Inc	32,500 (-30.3%)	$7.746M (-20.3%)	0.2%	$196.43	—	COM	023135106
IRON	Disc Medicine Inc	888,401 (-10.1%)	$64.98M (+2.8%)	1.3%	$57.60	—	COM	254604101
CRWD	CrowdStrike Holdings Inc	10,000 (-56.7%)	$7.631M (-15.3%)	0.2%	$328.72	—	CL A	22788C105
MSFT	Microsoft Corp	37,500 (-9.4%)	$13.99M (-8.7%)	0.3%	$431.05	—	COM	594918104

Unchanged Positions (38)

LXRX Lexicon Pharmaceuticals Inc 2.2%

Value $106M Shares 44,303,518 Est. Cost $1.73 Unrealized —

SLDB Solid Biosciences Inc 1.6%

Value $76.83M Shares 7,690,405 Est. Cost $5.85 Unrealized —

TRVI Trevi Therapeutics Inc 0.7%

Value $33.33M Shares 1,786,867 Est. Cost $4.03 Unrealized —

RELY Remitly Global Inc 0.7%

Value $34.58M Shares 1,543,271 Est. Cost $18.06 Unrealized —

MNPR Monopar Therapeutics Inc 0.5%

Value $25.01M Shares 270,118 Est. Cost $77.66 Unrealized —

DNLI Denali Therapeutics Inc 0.7%

Value $35.92M Shares 1,396,513 Est. Cost $21.53 Unrealized —

DBVT Dbv Technologies SA 0.6%

Value $30.46M Shares 1,857,362 Est. Cost $19.17 Unrealized —

PVLA Palvella Therapeutics Inc 0.8%

Value $39.35M Shares 257,485 Est. Cost $89.61 Unrealized —

RZLT Rezolute Inc 0.4%

Value $17.31M Shares 3,328,287 Est. Cost $3.06 Unrealized —

MPLT MapLight Therapeutics Inc 0.3%

Value $16.13M Shares 450,000 Est. Cost $16.75 Unrealized —

RAPP Rapport Therapeutics Inc 0.5%

Value $26.73M Shares 641,469 Est. Cost $19.15 Unrealized —

ONC BeOne Medicines AG 2.7%

Value $133M Shares 465,000 Est. Cost $220.70 Unrealized —

ORIC Oric Pharmaceuticals Inc 0.7%

Value $32.47M Shares 2,998,192 Est. Cost $10.47 Unrealized —

IONQ IONQ Inc 0.2%

Value $9.054M Shares 170,000 Est. Cost $7.62 Unrealized —

CTMX CytomX Therapeutics Inc 0.3%

Value $12.97M Shares 3,457,711 Est. Cost $5.23 Unrealized —

GENB Generate Biomedicines Inc 0.3%

Value $12.42M Shares 736,104 Est. Cost $12.50 Unrealized —

XENE Xenon Pharmaceuticals Inc 1.6%

Value $79.59M Shares 1,318,564 Est. Cost $40.49 Unrealized —

NMRA Neumora Therapeutics Inc 0.3%

Value $14.45M Shares 8,497,822 Est. Cost $7.19 Unrealized —

IKT Inhibikase Therapeutics Inc 0.2%

Value $11.88M Shares 5,850,000 Est. Cost $1.59 Unrealized —

MSLE Satellos Bioscience Inc 0.1%

Value $6.936M Shares 892,074 Est. Cost $5.63 Unrealized —

AGMB Agomab Therapeutics NV 0.1%

Value $5.338M Shares 411,250 Est. Cost $10.49 Unrealized —

GOSS Gossamer Bio Inc 0.0%

Value $857K Shares 5,208,968 Est. Cost $0.96 Unrealized —

KLRS Kalaris Therapeutics Inc 0.0%

Value $1.774M Shares 435,798 Est. Cost $8.34 Unrealized —

KRRO Korro Bio Inc 0.1%

Value $4.583M Shares 347,718 Est. Cost $42.09 Unrealized —

TENX Tenax Therapeutics Inc 0.1%

Value $6.215M Shares 427,141 Est. Cost $6.56 Unrealized —

VTVT vTv Therapeutics Inc 0.1%

Value $6.137M Shares 163,000 Est. Cost $17.30 Unrealized —

STOK Stoke Therapeutics Inc 1.3%

Value $65.29M Shares 1,995,347 Est. Cost $11.96 Unrealized —

AGEN Agenus Inc 0.1%

Value $3.257M Shares 1,064,250 Est. Cost $3.19 Unrealized —

CLBT Cellebrite DI Ltd 0.1%

Value $4.549M Shares 311,544 Est. Cost $16.47 Unrealized —

ZURA Zura Bio Ltd 0.4%

Value $22.04M Shares 3,734,866 Est. Cost $5.21 Unrealized —

FIG Figma Inc 0.0%

Value $905K Shares 50,000 Est. Cost $43.84 Unrealized —

MDLN Medline Inc 0.0%

Value $986K Shares 25,000 Est. Cost $42.23 Unrealized —

GLTO Damora Therapeutics Inc 0.5%

Value $23.41M Shares 900,000 Est. Cost $25.80 Unrealized —

FHTX Foghorn Therapeutics Inc 0.1%

Value $3.517M Shares 720,720 Est. Cost $7.24 Unrealized —

RANI Rani Therapeutics Holdings Inc 0.0%

Value $1.521M Shares 2,000,000 Est. Cost $1.51 Unrealized —

SEER Seer Inc 0.1%

Value $4.081M Shares 2,458,673 Est. Cost $1.75 Unrealized —

BEKE KE Holdings Inc 0.0%

Value $1.453M Shares 100,000 Est. Cost $19.71 Unrealized —

NU Nu Holdings Ltd. 0.0%

Value $334K Shares 25,000 Est. Cost $17.34 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
LXRX	Lexicon Pharmaceuticals Inc	44,303,518	$106M	2.2%	$1.73	—	COM NEW	528872302
SLDB	Solid Biosciences Inc	7,690,405	$76.83M	1.6%	$5.85	—	COM NEW	83422E204
TRVI	Trevi Therapeutics Inc	1,786,867	$33.33M	0.7%	$4.03	—	COM	89532M101
RELY	Remitly Global Inc	1,543,271	$34.58M	0.7%	$18.06	—	COM	75960P104
MNPR	Monopar Therapeutics Inc	270,118	$25.01M	0.5%	$77.66	—	COM NEW	61023L207
DNLI	Denali Therapeutics Inc	1,396,513	$35.92M	0.7%	$21.53	—	COM	24823R105
DBVT	Dbv Technologies SA	1,857,362	$30.46M	0.6%	$19.17	—	SPONSORED ADS	23306J309
PVLA	Palvella Therapeutics Inc	257,485	$39.35M	0.8%	$89.61	—	COM	697947109
RZLT	Rezolute Inc	3,328,287	$17.31M	0.4%	$3.06	—	COM NEW	76200L309
MPLT	MapLight Therapeutics Inc	450,000	$16.13M	0.3%	$16.75	—	COM	56565P103
RAPP	Rapport Therapeutics Inc	641,469	$26.73M	0.5%	$19.15	—	COM	75383L102
ONC	BeOne Medicines AG	465,000	$133M	2.7%	$220.70	—	SPONSORED ADS	07725L102
ORIC	Oric Pharmaceuticals Inc	2,998,192	$32.47M	0.7%	$10.47	—	COM	68622P109
IONQ	IONQ Inc	170,000	$9.054M	0.2%	$7.62	—	COM	46222L108
CTMX	CytomX Therapeutics Inc	3,457,711	$12.97M	0.3%	$5.23	—	COM	23284F105
GENB	Generate Biomedicines Inc	736,104	$12.42M	0.3%	$12.50	—	COM SHS	370920100
XENE	Xenon Pharmaceuticals Inc	1,318,564	$79.59M	1.6%	$40.49	—	COM	98420N105
NMRA	Neumora Therapeutics Inc	8,497,822	$14.45M	0.3%	$7.19	—	COM	640979100
IKT	Inhibikase Therapeutics Inc	5,850,000	$11.88M	0.2%	$1.59	—	COM NEW	45719W205
MSLE	Satellos Bioscience Inc	892,074	$6.936M	0.1%	$5.63	—	COM	80401L803
AGMB	Agomab Therapeutics NV	411,250	$5.338M	0.1%	$10.49	—	SPONSORED ADS	00860C102
GOSS	Gossamer Bio Inc	5,208,968	$857K	0.0%	$0.96	—	COM	38341P102
KLRS	Kalaris Therapeutics Inc	435,798	$1.774M	0.0%	$8.34	—	COM	482929106
KRRO	Korro Bio Inc	347,718	$4.583M	0.1%	$42.09	—	COM	500946108
TENX	Tenax Therapeutics Inc	427,141	$6.215M	0.1%	$6.56	—	COM NEW	88032L605
VTVT	vTv Therapeutics Inc	163,000	$6.137M	0.1%	$17.30	—	CL A NEW	918385204
STOK	Stoke Therapeutics Inc	1,995,347	$65.29M	1.3%	$11.96	—	COM	86150R107
AGEN	Agenus Inc	1,064,250	$3.257M	0.1%	$3.19	—	COM NEW	00847G804
CLBT	Cellebrite DI Ltd	311,544	$4.549M	0.1%	$16.47	—	ORDINARY SHARES	M2197Q107
ZURA	Zura Bio Ltd	3,734,866	$22.04M	0.4%	$5.21	—	CLASS A ORD SHS	G9TY5A101
FIG	Figma Inc	50,000	$905K	0.0%	$43.84	—	CLASS A COM STK	316841105
MDLN	Medline Inc	25,000	$986K	0.0%	$42.23	—	COM CL A	58507V107
GLTO	Damora Therapeutics Inc	900,000	$23.41M	0.5%	$25.80	—	COM NEW	36322Q206
FHTX	Foghorn Therapeutics Inc	720,720	$3.517M	0.1%	$7.24	—	COM	344174107
RANI	Rani Therapeutics Holdings Inc	2,000,000	$1.521M	0.0%	$1.51	—	COM CL A	753018100
SEER	Seer Inc	2,458,673	$4.081M	0.1%	$1.75	—	COM CL A	81578P106
BEKE	KE Holdings Inc	100,000	$1.453M	0.0%	$19.71	—	SPONSORED ADS	482497104
NU	Nu Holdings Ltd.	25,000	$334K	0.0%	$17.34	—	ORD SHS CL A	G6683N103