AGIOS PHARMACEUTICALS INC

Ticker: AGIO CUSIP: 00847X104 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018

Shares 67,500 Value ($000) $3,112 Avg Close $61.72 Range $41.63 - $79.17

Q1 2016

Shares 50,000 Value ($000) $2,030 Avg Close $42.75 Range $33.50 - $66.87

Q4 2015

Shares 50,000 Value ($000) $3,246 Avg Close $65.59 Range $48.00 - $81.77

Q3 2014

Shares 405 Value ($000) $25 Avg Close $43.10 Range $33.01 - $69.50

Q2 2014

Shares 25,000 Value ($000) $1,146 Avg Close $40.76 Range $31.42 - $50.37

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2018	67,500	$3,112	$61.72	$41.63 - $79.17
Q1 2016	50,000	$2,030	$42.75	$33.50 - $66.87
Q4 2015	50,000	$3,246	$65.59	$48.00 - $81.77
Q3 2014	405	$25	$43.10	$33.01 - $69.50
Q2 2014	25,000	$1,146	$40.76	$31.42 - $50.37