AMYLYX PHARMACEUTICALS INC

Ticker: AMLX CUSIP: 03237H101 Class: Common Stock

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 750,600 Value ($000) $10,201 Avg Close $9.41 Range $5.97 - $15.14

Q2 2025

Shares 313,200 Value ($000) $2,008 Avg Close $4.86 Range $3.11 - $6.70

Q1 2025

Shares 348,000 Value ($000) $1,232 Avg Close $3.56 Range $2.60 - $4.18

Q4 2024

Shares 348,000 Value ($000) $1,315 Avg Close $4.71 Range $2.91 - $7.27

Q1 2023

Shares 813,500 Value ($000) $23,868 Avg Close $34.74 Range $26.64 - $41.93

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	750,600	$10,201	$9.41	$5.97 - $15.14
Q2 2025	313,200	$2,008	$4.86	$3.11 - $6.70
Q1 2025	348,000	$1,232	$3.56	$2.60 - $4.18
Q4 2024	348,000	$1,315	$4.71	$2.91 - $7.27
Q1 2023	813,500	$23,868	$34.74	$26.64 - $41.93