Ticker: ANNX CUSIP: 03589W102 Class: COM
Note: Option positions (PUT/CALL) are excluded.
| Institution | Shares | Value ($000) |
|---|---|---|
| Palo Alto Investors LP | 2,384,192 | $11,969 |
| MAK CAPITAL ONE LLC | 2,958,527 | $14,852 |
| Longaeva Partners L.P. | 3,100,000 | $15,562 |
| DIADEMA PARTNERS LP | 350,000 | $1,757 |
| DAFNA Capital Management LLC | 272,812 | $1,370 |
| Persistent Asset Partners Ltd | 93,657 | $470 |
| Ikarian Capital, LLC | 230,244 | $1,156 |
| Landing Point Financial Group, LLC | 34,900 | $175 |
| Scientech Research LLC | 17,216 | $86 |
| Caitong International Asset Management Co., Ltd | 19,197 | $96 |
| ADAR1 Capital Management, LLC | 48,000 | $241 |
| Pale Fire Capital SE | 38,600 | $194 |
| WINTON GROUP Ltd | 53,400 | $268 |
| Jump Financial, LLC | 122,858 | $617 |
| D. E. Shaw & Co., Inc. | 1,046,221 | $5,252 |
| PROFUND ADVISORS LLC | 53,008 | $266 |
| MARSHALL WACE, LLP | 520,998 | $2,615 |
| MOUNT VERNON ASSOCIATES INC /MD/ | 10,500 | $0 |
| Caption Management, LLC | 119,491 | $600 |
| BOOTHBAY FUND MANAGEMENT, LLC | 64,069 | $322 |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| Redmile Group, LLC | 6,300,644 | 10,050,644 | +3,750,000 (+59.5%) |
| BVF INC/IL | 7,000,000 | 9,128,080 | +2,128,080 (+30.4%) |
| Parkman Healthcare Partners LLC | 405,953 | 601,202 | +195,249 (+48.1%) |
| Cinctive Capital Management LP | 65,466 | 358,986 | +293,520 (+448.4%) |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,500,000 | 5,500,000 | +4,000,000 (+266.7%) |
| Woodline Partners LP | 2,638,275 | 4,000,074 | +1,361,799 (+51.6%) |
| SummitTX Capital, L.P. | 241,991 | 438,497 | +196,506 (+81.2%) |
| EntryPoint Capital, LLC | 19,971 | 42,774 | +22,803 (+114.2%) |
| BALYASNY ASSET MANAGEMENT L.P. | 1,297,260 | 3,299,256 | +2,001,996 (+154.3%) |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 22,589 | 683,879 | +661,290 (+2927.5%) |
| Qube Research & Technologies Ltd | 572,644 | 2,381,479 | +1,808,835 (+315.9%) |
| XTX Topco Ltd | 147,840 | 243,313 | +95,473 (+64.6%) |
| Hennion & Walsh Asset Management, Inc. | 475,929 | 534,986 | +59,057 (+12.4%) |
| Virtus Investment Advisers, LLC | 41,987 | 53,527 | +11,540 (+27.5%) |
| Schonfeld Strategic Advisors LLC | 212,219 | 522,846 | +310,627 (+146.4%) |
| Nuveen, LLC | 682,558 | 2,915,324 | +2,232,766 (+327.1%) |
| AMERIPRISE FINANCIAL INC | 2,192,354 | 4,348,782 | +2,156,428 (+98.4%) |
| Russell Investments Group, Ltd. | 18,220 | 683,016 | +664,796 (+3648.7%) |
| STATE STREET CORP | 2,050,308 | 4,652,185 | +2,601,877 (+126.9%) |
| VANGUARD GROUP INC | 5,835,112 | 7,753,387 | +1,918,275 (+32.9%) |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| SPHERA FUNDS MANAGEMENT LTD. | 1,794,387 | 1,316,212 | -478,175 (-26.6%) |
| Tetragon Partners GP Ltd | 2,112,455 | 2,032,455 | -80,000 (-3.8%) |
| SIRIOS CAPITAL MANAGEMENT L P | 970,200 | 710,256 | -259,944 (-26.8%) |
| Forefront Analytics, LLC | 27,027 | 13,226 | -13,801 (-51.1%) |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 1,066,932 | 642,038 | -424,894 (-39.8%) |
| Quarry LP | 110,000 | 75,000 | -35,000 (-31.8%) |
| J. Goldman & Co LP | 1,107,001 | 993,795 | -113,206 (-10.2%) |
| J. Safra Sarasin Holding AG | 223,221 | 117,768 | -105,453 (-47.2%) |
| DEUTSCHE BANK AG\ | 1,504,349 | 560,744 | -943,605 (-62.7%) |
| FMR LLC | 11,081,163 | 10,222,470 | -858,693 (-7.7%) |
| GOLDMAN SACHS GROUP INC | 2,406,432 | 1,768,745 | -637,687 (-26.5%) |
| ROYAL BANK OF CANADA | 285,848 | 2,855 | -282,993 (-99.0%) |
| MORGAN STANLEY | 3,029,848 | 2,856,143 | -173,705 (-5.7%) |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 980,285 | 903,439 | -76,846 (-7.8%) |
| DIMENSIONAL FUND ADVISORS LP | 766,955 | 718,680 | -48,275 (-6.3%) |
| GROUP ONE TRADING, L.P. | 35,565 | 14,184 | -21,381 (-60.1%) |
| SRS Capital Advisors, Inc. | 6,530 | 19 | -6,511 (-99.7%) |
| RHUMBLINE ADVISERS | 132,603 | 126,463 | -6,140 (-4.6%) |
| MetLife Investment Management, LLC | 44,632 | 39,059 | -5,573 (-12.5%) |
| Tower Research Capital LLC (TRC) | 6,096 | 1,966 | -4,130 (-67.7%) |
| Institution | Prev Shares | Prev Value ($000) |
|---|---|---|
| Rhenman & Partners Asset Management AB | 823,000 | $2,510 |
| Candriam S.C.A. | 2,534,230 | $7,729 |
| Forefront Wealth Partners, LLC | 27,027 | $82 |
| ExodusPoint Capital Management, LP | 243,755 | $743 |
| MATAURO, LLC | 20,572 | $63 |
| Atom Investors LP | 30,453 | $93 |
| 49 WEALTH MANAGEMENT, LLC | 12,083 | $37 |
| ALPS ADVISORS INC | 47,879 | $146 |
| TWO SIGMA ADVISERS, LP | 23,800 | $73 |
| PRUDENTIAL FINANCIAL INC | 11,670 | $36 |
| CIBC WORLD MARKETS CORP | 11,799 | $28 |
| PARK AVENUE SECURITIES LLC | 113,068 | $0 |
| Clearstead Advisors, LLC | 355 | $1 |
| HRT FINANCIAL LP | 84,582 | $0 |
| Advisory Services Network, LLC | 23 | $0 |