| FMR LLC | 10,222,470 | $51,317 |
| Redmile Group, LLC | 10,050,644 | $50,454 |
| BVF INC/IL | 9,128,080 | $45,823 |
| BlackRock, Inc. | 8,960,434 | $44,981 |
| VANGUARD GROUP INC | 7,753,387 | $38,922 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,500,000 | $27,610 |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | $26,350 |
| Bellevue Group AG | 5,157,290 | $25,890 |
| STATE STREET CORP | 4,652,185 | $23,354 |
| AMERIPRISE FINANCIAL INC | 4,348,782 | $21,831 |
| Woodline Partners LP | 4,000,074 | $20,080 |
| BALYASNY ASSET MANAGEMENT L.P. | 3,299,256 | $16,562 |
| Longaeva Partners L.P. | 3,100,000 | $15,562 |
| MAK CAPITAL ONE LLC | 2,958,527 | $14,852 |
| Nuveen, LLC | 2,915,324 | $14,635 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,902,896 | $14,576 |
| MORGAN STANLEY | 2,856,143 | $14,338 |
| MILLENNIUM MANAGEMENT LLC | 2,836,857 | $14,241 |
| Opaleye Management Inc. | 2,600,000 | $13,052 |
| Palo Alto Investors LP | 2,384,192 | $11,969 |
| Qube Research & Technologies Ltd | 2,381,479 | $11,955 |
| Tetragon Partners GP Ltd | 2,032,455 | $10,203 |
| GOLDMAN SACHS GROUP INC | 1,768,745 | $8,879 |
| BANK OF AMERICA CORP /DE/ | 1,605,581 | $8,060 |
| SPHERA FUNDS MANAGEMENT LTD. | 1,316,212 | $6,607 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,057,060 | $5,306 |
| D. E. Shaw & Co., Inc. | 1,046,221 | $5,252 |
| J. Goldman & Co LP | 993,795 | $4,989 |
| Invesco Ltd. | 972,449 | $4,882 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 903,439 | $4,535 |
| ACADIAN ASSET MANAGEMENT LLC | 861,245 | $4 |
| RENAISSANCE TECHNOLOGIES LLC | 802,600 | $4,029 |
| NORTHERN TRUST CORP | 792,000 | $3,976 |
| AQR CAPITAL MANAGEMENT LLC | 776,307 | $3,897 |
| Ishara Investments LP | 750,000 | $3,765 |
| DIMENSIONAL FUND ADVISORS LP | 718,680 | $3,608 |
| SIRIOS CAPITAL MANAGEMENT L P | 710,256 | $3,565 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 683,879 | $3,433 |
| Russell Investments Group, Ltd. | 683,016 | $3,429 |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 642,038 | $3,223 |
| KENNEDY CAPITAL MANAGEMENT LLC | 639,902 | $3,212 |
| Parkman Healthcare Partners LLC | 601,202 | $3,018 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | $2,931 |
| WELLS FARGO & COMPANY/MN | 573,748 | $2,880 |
| DEUTSCHE BANK AG\ | 560,744 | $2,815 |
| Hennion & Walsh Asset Management, Inc. | 534,986 | $2,686 |
| Schonfeld Strategic Advisors LLC | 522,846 | $2,625 |
| MARSHALL WACE, LLP | 520,998 | $2,615 |
| JANE STREET GROUP, LLC | 513,836 | $2,579 |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | $2,422 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 445,074 | $2 |
| SummitTX Capital, L.P. | 438,497 | $2,201 |
| WELLINGTON MANAGEMENT GROUP LLP | 398,077 | $1,998 |
| UBS Group AG | 377,104 | $1,893 |
| Point72 Asset Management, L.P. | 371,190 | $1,863 |
| Bank of New York Mellon Corp | 361,677 | $1,816 |
| Cinctive Capital Management LP | 358,986 | $1,802 |
| Susquehanna Portfolio Strategies, LLC | 356,619 | $1,790 |
| DIADEMA PARTNERS LP | 350,000 | $1,757 |
| TWO SIGMA INVESTMENTS, LP | 332,038 | $1,667 |
| BARCLAYS PLC | 289,963 | $1,456 |
| CITADEL ADVISORS LLC | 275,294 | $1,382 |
| DAFNA Capital Management LLC | 272,812 | $1,370 |
| AMERICAN CENTURY COMPANIES INC | 251,158 | $1,261 |
| XTX Topco Ltd | 243,313 | $1,221 |
| Ikarian Capital, LLC | 230,244 | $1,156 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 185,508 | $931 |
| IEQ CAPITAL, LLC | 182,982 | $919 |
| OSAIC HOLDINGS, INC. | 147,375 | $740 |
| Rafferty Asset Management, LLC | 141,644 | $711 |
| ALLIANCEBERNSTEIN L.P. | 140,740 | $707 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 137,800 | $692 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 130,102 | $655 |
| RHUMBLINE ADVISERS | 126,463 | $635 |
| Brevan Howard Capital Management LP | 123,753 | $621 |
| Jump Financial, LLC | 122,858 | $617 |
| Caption Management, LLC | 119,491 | $600 |
| DnB Asset Management AS | 118,324 | $594 |
| J. Safra Sarasin Holding AG | 117,768 | $591 |
| Persistent Asset Partners Ltd | 93,657 | $470 |
| Quarry LP | 75,000 | $377 |
| BOOTHBAY FUND MANAGEMENT, LLC | 64,069 | $322 |
| BNP PARIBAS ARBITRAGE, SA | 61,572 | $309 |
| SEI INVESTMENTS CO | 58,259 | $292 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 54,763 | $275 |
| JPMORGAN CHASE & CO | 53,729 | $270 |
| Virtus Investment Advisers, LLC | 53,527 | $269 |
| WINTON GROUP Ltd | 53,400 | $268 |
| PROFUND ADVISORS LLC | 53,008 | $266 |
| Quadrature Capital Ltd | 48,573 | $244 |
| ADAR1 Capital Management, LLC | 48,000 | $241 |
| TD Asset Management Inc | 46,848 | $235 |
| Allegheny Financial Group LTD | 42,900 | $215 |
| EntryPoint Capital, LLC | 42,774 | $215 |
| INTECH INVESTMENT MANAGEMENT LLC | 42,524 | $213 |
| CITIZENS FINANCIAL GROUP INC/RI | 40,000 | $201 |
| MetLife Investment Management, LLC | 39,059 | $196 |
| Pale Fire Capital SE | 38,600 | $194 |
| China Universal Asset Management Co., Ltd. | 36,084 | $181 |
| Lido Advisors, LLC | 34,952 | $107 |
| 66 other institutions | 755,553 | $3,380 |