APELLIS PHARMACEUTICALS INC

Ticker: APLS CUSIP: 03753U106 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019

Shares 115,000 Value ($000) $2,243 Avg Close $15.73 Range $12.50 - $20.03

Q4 2018

Shares 275,000 Value ($000) $3,627 Avg Close $15.34 Range $11.45 - $20.54

Q3 2018

Shares 375,000 Value ($000) $6,667 Avg Close $18.48 Range $16.25 - $21.93

Q2 2018

Shares 265,000 Value ($000) $5,830 Avg Close $22.98 Range $18.89 - $32.00

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2019	115,000	$2,243	$15.73	$12.50 - $20.03
Q4 2018	275,000	$3,627	$15.34	$11.45 - $20.54
Q3 2018	375,000	$6,667	$18.48	$16.25 - $21.93
Q2 2018	265,000	$5,830	$22.98	$18.89 - $32.00