APELLIS PHARMACEUTICALS INC

Ticker: APLS CUSIP: 03753U106 Class: Common Stock

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 2,578,396 Value ($000) $64,769 Avg Close $23.46 Range $18.75 - $30.48

Q3 2025

Shares 2,578,396 Value ($000) $58,349 Avg Close $23.32 Range $17.35 - $28.97

Q2 2025

Shares 2,578,396 Value ($000) $44,632 Avg Close $18.51 Range $16.10 - $23.77

Q1 2025

Shares 2,578,396 Value ($000) $56,390 Avg Close $27.62 Range $21.70 - $35.57

Q4 2024

Shares 2,816,258 Value ($000) $89,867 Avg Close $30.07 Range $24.34 - $35.72

Q3 2024

Shares 2,167,224 Value ($000) $62,503 Avg Close $37.03 Range $28.32 - $42.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	2,578,396	$64,769	$23.46	$18.75 - $30.48
Q3 2025	2,578,396	$58,349	$23.32	$17.35 - $28.97
Q2 2025	2,578,396	$44,632	$18.51	$16.10 - $23.77
Q1 2025	2,578,396	$56,390	$27.62	$21.70 - $35.57
Q4 2024	2,816,258	$89,867	$30.07	$24.34 - $35.72
Q3 2024	2,167,224	$62,503	$37.03	$28.32 - $42.47