APOGEE THERAPEUTICS INC

Ticker: APGE CUSIP: 03770N101 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 388,257 Value ($000) $29,306 Avg Close $62.99 Range $38.88 - $80.99

Q3 2025

Shares 363,257 Value ($000) $14,432 Avg Close $38.18 Range $34.34 - $47.71

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	388,257	$29,306	$62.99	$38.88 - $80.99
Q3 2025	363,257	$14,432	$38.18	$34.34 - $47.71