APPLIED THERAPEUTICS INC

CUSIP: 03828A101 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 50,000 Value ($000) $5 Avg Close — Range —
Q3 2025
Shares 50,000 Value ($000) $30 Avg Close — Range —
Q2 2025
Shares 50,000 Value ($000) $16 Avg Close — Range —
Q1 2025
Shares 50,000 Value ($000) $24 Avg Close — Range —
Q4 2024
Shares 50,000 Value ($000) $43 Avg Close — Range —
Q3 2024
Shares 311,572 Value ($000) $2,648 Avg Close — Range —
Q2 2024
Shares 674,268 Value ($000) $3,149 Avg Close — Range —
Q1 2024
Shares 619,029 Value ($000) $4,209 Avg Close — Range —
Q1 2020
Shares 67,967 Value ($000) $2,222 Avg Close — Range —