ARROWHEAD PHARMACEUTICALS IN

Ticker: ARWR CUSIP: 04280A100 Class: Common Stock

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,500,476 Value ($000) $99,617 Avg Close $49.01 Range $34.38 - $72.36

Q3 2025

Shares 2,669,880 Value ($000) $92,084 Avg Close $21.98 Range $14.30 - $34.61

Q2 2025

Shares 2,669,880 Value ($000) $42,184 Avg Close $14.35 Range $9.57 - $17.49

Q1 2025

Shares 2,669,880 Value ($000) $34,014 Avg Close $18.18 Range $12.14 - $21.84

Q4 2024

Shares 2,901,681 Value ($000) $54,552 Avg Close $20.59 Range $17.05 - $27.34

Q3 2024

Shares 2,458,778 Value ($000) $47,627 Avg Close $24.41 Range $19.07 - $30.41

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,500,476	$99,617	$49.01	$34.38 - $72.36
Q3 2025	2,669,880	$92,084	$21.98	$14.30 - $34.61
Q2 2025	2,669,880	$42,184	$14.35	$9.57 - $17.49
Q1 2025	2,669,880	$34,014	$18.18	$12.14 - $21.84
Q4 2024	2,901,681	$54,552	$20.59	$17.05 - $27.34
Q3 2024	2,458,778	$47,627	$24.41	$19.07 - $30.41