AXSOME THERAPEUTICS INC

Ticker: AXSM CUSIP: 05464T104 Class: Common Stock

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 253,121 Value ($000) $46,230 Avg Close $139.61 Range $117.30 - $184.40

Q3 2025

Shares 531,800 Value ($000) $64,587 Avg Close $112.64 Range $96.09 - $130.00

Q2 2025

Shares 427,900 Value ($000) $44,668 Avg Close $105.89 Range $86.99 - $120.00

Q1 2025

Shares 386,700 Value ($000) $45,101 Avg Close $113.93 Range $79.19 - $139.13

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	253,121	$46,230	$139.61	$117.30 - $184.40
Q3 2025	531,800	$64,587	$112.64	$96.09 - $130.00
Q2 2025	427,900	$44,668	$105.89	$86.99 - $120.00
Q1 2025	386,700	$45,101	$113.93	$79.19 - $139.13