| EVENTIDE ASSET MANAGEMENT, LLC | 4,994,728 | $152,233 |
| FARALLON CAPITAL MANAGEMENT LLC | 4,313,920 | $131,445 |
| Sands Capital Ventures, LLC | 3,570,113 | $108,781 |
| MORGAN STANLEY | 3,459,453 | $105,410 |
| BlackRock, Inc. | 2,913,920 | $88,787 |
| Soleus Capital Management, L.P. | 2,534,565 | $77,228 |
| RTW INVESTMENTS, LP | 2,500,000 | $76,175 |
| VANGUARD GROUP INC | 2,218,238 | $67,590 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1,327,100 | $40,437 |
| Omega Fund Management, LLC | 1,316,183 | $40,104 |
| Point72 Asset Management, L.P. | 987,351 | $30,085 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 956,784 | $29,153 |
| MILLENNIUM MANAGEMENT LLC | 945,461 | $28,808 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 938,308 | $28,590 |
| GEODE CAPITAL MANAGEMENT, LLC | 921,464 | $28,084 |
| STATE STREET CORP | 863,133 | $26,300 |
| Eversept Partners, LP | 678,262 | $20,667 |
| Walleye Capital LLC | 646,539 | $19,700 |
| PERCEPTIVE ADVISORS LLC | 602,944 | $18,372 |
| Vestal Point Capital, LP | 600,000 | $18,282 |
| 12 West Capital Management LP | 575,000 | $17,520 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 532,749 | $16 |
| BANK OF AMERICA CORP /DE/ | 432,340 | $13,173 |
| LORD, ABBETT & CO. LLC | 430,403 | $13 |
| TWO SIGMA INVESTMENTS, LP | 410,603 | $12,511 |
| GOLDMAN SACHS GROUP INC | 405,408 | $12,353 |
| JPMORGAN CHASE & CO | 348,671 | $10,624 |
| NORGES BANK | 339,300 | $10,338 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 331,623 | $10,105 |
| CITADEL ADVISORS LLC | 320,880 | $9,777 |
| NORTHERN TRUST CORP | 284,453 | $8,667 |
| PURA VIDA INVESTMENTS, LLC | 281,250 | $8,570 |
| TUDOR INVESTMENT CORP ET AL | 259,632 | $7,911 |
| First Eagle Investment Management, LLC | 253,702 | $7,730 |
| UBS Group AG | 251,438 | $7,661 |
| MARSHALL WACE, LLP | 227,956 | $6,946 |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 217,796 | $6,636 |
| Russell Investments Group, Ltd. | 205,837 | $6,272 |
| BNP PARIBAS ARBITRAGE, SA | 201,892 | $6,152 |
| RAYMOND JAMES FINANCIAL INC | 197,939 | $6,318 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 151,647 | $4,621 |
| SG Americas Securities, LLC | 150,277 | $5 |
| JANE STREET GROUP, LLC | 140,592 | $4,284 |
| Freestone Grove Partners LP | 138,138 | $4,209 |
| TWO SIGMA ADVISERS, LP | 137,200 | $4,180 |
| Granahan Investment Management, LLC | 121,246 | $3,694 |
| Invesco Ltd. | 117,360 | $3,576 |
| Trexquant Investment LP | 115,761 | $3,527 |
| Bank of New York Mellon Corp | 99,783 | $3,040 |
| Quantbot Technologies LP | 89,405 | $2,724 |
| Jump Financial, LLC | 86,504 | $2,636 |
| Nuveen, LLC | 85,379 | $2,601 |
| BALYASNY ASSET MANAGEMENT L.P. | 84,973 | $2,589 |
| Squarepoint Ops LLC | 83,421 | $2,542 |
| Verition Fund Management LLC | 82,862 | $2,525 |
| Bellevue Group AG | 72,285 | $2,203 |
| Holocene Advisors, LP | 71,777 | $2,187 |
| TD Asset Management Inc | 65,876 | $2,007 |
| BARCLAYS PLC | 60,664 | $1,848 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 54,541 | $1,662 |
| Jefferies Financial Group Inc. | 51,400 | $1,566 |
| AQR CAPITAL MANAGEMENT LLC | 50,405 | $1,536 |
| WELLS FARGO & COMPANY/MN | 50,312 | $1,533 |
| OSAIC HOLDINGS, INC. | 48,100 | $1,465 |
| SEI INVESTMENTS CO | 48,074 | $1,465 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,439 | $1,467 |
| XTX Topco Ltd | 43,990 | $1,340 |
| Lisanti Capital Growth, LLC | 42,985 | $1,310 |
| RHUMBLINE ADVISERS | 42,858 | $1,306 |
| Divisadero Street Capital Management, LP | 39,606 | $1,207 |
| DEUTSCHE BANK AG\ | 39,300 | $1,197 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 37,374 | $1,139 |
| Calamos Advisors LLC | 36,091 | $1,100 |
| ALLIANCEBERNSTEIN L.P. | 35,400 | $1,079 |
| Values First Advisors, Inc. | 35,191 | $1,072 |
| Lighthouse Investment Partners, LLC | 35,000 | $1,066 |
| Numerai GP LLC | 34,285 | $1,045 |
| AMERIPRISE FINANCIAL INC | 32,409 | $988 |
| Quantinno Capital Management LP | 31,883 | $971 |
| Evanson Asset Management, LLC | 31,272 | $953 |
| Voya Investment Management LLC | 30,366 | $925 |
| Vontobel Holding Ltd. | 24,152 | $736 |
| MetLife Investment Management, LLC | 22,720 | $692 |
| DARK FOREST CAPITAL MANAGEMENT LP | 20,906 | $637 |
| Mariner, LLC | 20,671 | $630 |
| GSA CAPITAL PARTNERS LLP | 18,744 | $1 |
| Qube Research & Technologies Ltd | 17,378 | $530 |
| FMR LLC | 17,111 | $521 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,833 | $452 |
| Gladstone Institutional Advisory LLC | 14,200 | $433 |
| Sigma Planning Corp | 13,500 | $411 |
| D. E. Shaw & Co., Inc. | 13,142 | $400 |
| INTECH INVESTMENT MANAGEMENT LLC | 12,891 | $393 |
| BANK OF MONTREAL /CAN/ | 12,861 | $392 |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,200 | $372 |
| Caprock Group, LLC | 12,117 | $369 |
| AMERICAN CENTURY COMPANIES INC | 12,024 | $366 |
| BROWN ADVISORY INC | 11,946 | $364 |
| Man Group plc | 11,321 | $345 |
| Y-Intercept (Hong Kong) Ltd | 11,203 | $341 |
| 55 other institutions | 176,517 | $5,237 |