BICYCLE THERAPEUTICS PLC

Ticker: BCYC CUSIP: 088786108 Class: ADR

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 2,012,752 Value ($000) $14,250 Avg Close — Range —
Q3 2025
Shares 2,012,752 Value ($000) $15,579 Avg Close — Range —
Q2 2025
Shares 2,012,752 Value ($000) $13,989 Avg Close — Range —
Q1 2025
Shares 1,812,752 Value ($000) $15,390 Avg Close — Range —
Q4 2024
Shares 1,839,398 Value ($000) $25,752 Avg Close — Range —