C4 THERAPEUTICS INC

Ticker: CCCC CUSIP: 12529R107 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q2 2022

Shares 705,736 Value ($000) $5,321 Avg Close $8.80 Range $4.84 - $26.80

Q1 2022

Shares 362,528 Value ($000) $8,795 Avg Close $24.28 Range $19.81 - $33.76

Q4 2021

Shares 398,469 Value ($000) $12,831 Avg Close $39.55 Range $27.84 - $48.75

Q3 2021

Shares 381,774 Value ($000) $17,058 Avg Close $42.82 Range $34.47 - $51.21

Q2 2021

Shares 518,611 Value ($000) $19,624 Avg Close $35.81 Range $29.55 - $43.50

Q1 2021

Shares 497,136 Value ($000) $18,389 Avg Close $39.78 Range $30.55 - $48.98

Q4 2020

Shares 443,824 Value ($000) $14,601 Avg Close $29.00 Range $22.40 - $37.80

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2022	705,736	$5,321	$8.80	$4.84 - $26.80
Q1 2022	362,528	$8,795	$24.28	$19.81 - $33.76
Q4 2021	398,469	$12,831	$39.55	$27.84 - $48.75
Q3 2021	381,774	$17,058	$42.82	$34.47 - $51.21
Q2 2021	518,611	$19,624	$35.81	$29.55 - $43.50
Q1 2021	497,136	$18,389	$39.78	$30.55 - $48.98
Q4 2020	443,824	$14,601	$29.00	$22.40 - $37.80