| Point72 Asset Management, L.P. | 9,439,328 | $18,029 |
| MORGAN STANLEY | 8,981,662 | $17,155 |
| RA CAPITAL MANAGEMENT, L.P. | 8,000,000 | $15,280 |
| Bain Capital Life Sciences Investors, LLC | 7,171,910 | $13,698 |
| Lynx1 Capital Management LP | 7,098,133 | $13,557 |
| VANGUARD GROUP INC | 4,379,815 | $8,365 |
| WASATCH ADVISORS LP | 4,344,918 | $8,299 |
| Soleus Capital Management, L.P. | 3,803,942 | $7,266 |
| BANK OF AMERICA CORP /DE/ | 2,387,586 | $4,560 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,994,224 | $3,809 |
| BlackRock, Inc. | 1,969,814 | $3,762 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,775,783 | $3,392 |
| RENAISSANCE TECHNOLOGIES LLC | 1,602,580 | $3,061 |
| TWO SIGMA INVESTMENTS, LP | 1,509,603 | $2,883 |
| ORBIMED ADVISORS LLC | 1,404,902 | $2,683 |
| MILLENNIUM MANAGEMENT LLC | 1,188,969 | $2,271 |
| GOLDMAN SACHS GROUP INC | 1,089,020 | $2,080 |
| TWO SIGMA ADVISERS, LP | 1,068,200 | $2,040 |
| GEODE CAPITAL MANAGEMENT, LLC | 988,878 | $1,889 |
| JANE STREET GROUP, LLC | 874,794 | $1,671 |
| WELLS FARGO & COMPANY/MN | 809,260 | $1,546 |
| ACADIAN ASSET MANAGEMENT LLC | 657,173 | $1 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 449,432 | $858 |
| CITADEL ADVISORS LLC | 447,808 | $855 |
| Walleye Capital LLC | 443,341 | $847 |
| 683 Capital Management, LLC | 400,000 | $764 |
| STATE STREET CORP | 342,773 | $655 |
| DIMENSIONAL FUND ADVISORS LP | 296,480 | $566 |
| Qube Research & Technologies Ltd | 290,234 | $554 |
| Susquehanna Portfolio Strategies, LLC | 272,053 | $520 |
| Invesco Ltd. | 268,350 | $513 |
| MARSHALL WACE, LLP | 265,027 | $506 |
| FMR LLC | 254,406 | $486 |
| LPL Financial LLC | 243,305 | $465 |
| Hennion & Walsh Asset Management, Inc. | 237,137 | $453 |
| BARCLAYS PLC | 219,204 | $419 |
| ArrowMark Colorado Holdings LLC | 204,505 | $391 |
| NORTHERN TRUST CORP | 166,207 | $317 |
| Man Group plc | 156,098 | $298 |
| Squarepoint Ops LLC | 136,054 | $260 |
| Quadrature Capital Ltd | 133,112 | $254 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 131,100 | $250 |
| Mariner, LLC | 128,050 | $245 |
| OMERS ADMINISTRATION Corp | 117,700 | $225 |
| Hudson Bay Capital Management LP | 111,551 | $213 |
| Atom Investors LP | 104,964 | $200 |
| XTX Topco Ltd | 104,458 | $200 |
| Graham Capital Management, L.P. | 102,198 | $195 |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | $162 |
| AMERICAN CENTURY COMPANIES INC | 68,245 | $130 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 67,617 | $129 |
| Crestwood Advisors Group LLC | 66,536 | $127 |
| ExodusPoint Capital Management, LP | 62,165 | $119 |
| INTREPID FAMILY OFFICE LLC | 55,000 | $105 |
| D. E. Shaw & Co., Inc. | 52,879 | $101 |
| UBS Group AG | 52,752 | $101 |
| CITIGROUP INC | 49,840 | $95 |
| Catalyst Funds Management Pty Ltd | 42,500 | $81 |
| GROUP ONE TRADING, L.P. | 38,994 | $74 |
| Focus Partners Wealth | 38,187 | $73 |
| Connor, Clark & Lunn Investment Management Ltd. | 37,721 | $72 |
| Jefferies Financial Group Inc. | 35,340 | $67 |
| Lighthouse Investment Partners, LLC | 33,660 | $64 |
| Callan Family Office, LLC | 31,743 | $61 |
| SIMPLEX TRADING, LLC | 30,658 | $59 |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,500 | $56 |
| FARALLON CAPITAL MANAGEMENT LLC | 28,000 | $53 |
| Tower Research Capital LLC (TRC) | 25,980 | $50 |
| Cresset Asset Management, LLC | 25,000 | $48 |
| Engineers Gate Manager LP | 24,416 | $47 |
| Corient Private Wealth LLC | 21,387 | $41 |
| Virtu Financial LLC | 20,655 | $0 |
| Delta Investment Management, LLC | 20,000 | $38 |
| EWA, LLC | 16,889 | $32 |
| China Universal Asset Management Co., Ltd. | 15,792 | $30 |
| Vanguard Personalized Indexing Management, LLC | 15,224 | $29 |
| PRUDENTIAL FINANCIAL INC | 15,050 | $29 |
| R Squared Ltd | 13,674 | $26 |
| HSBC HOLDINGS PLC | 13,629 | $26 |
| Jain Global LLC | 12,762 | $24 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,400 | $0 |
| NINE MASTS CAPITAL Ltd | 11,472 | $22 |
| Ethic Inc. | 10,278 | $20 |
| Simplicity Wealth,LLC | 10,202 | $19 |
| Abel Hall, LLC | 10,140 | $19 |
| Bronte Capital Management Pty Ltd. | 10,033 | $19 |
| Blackston Financial Advisory Group, LLC | 10,000 | $19 |
| JPMORGAN CHASE & CO | 5,945 | $11 |
| Mirae Asset Global Investments Co., Ltd. | 4,709 | $9 |
| OSAIC HOLDINGS, INC. | 4,544 | $9 |
| NBC SECURITIES, INC. | 4,000 | $8 |
| RHUMBLINE ADVISERS | 2,716 | $5 |
| BNP PARIBAS ARBITRAGE, SA | 2,161 | $4 |
| GF FUND MANAGEMENT CO. LTD. | 1,903 | $4 |
| Federation des caisses Desjardins du Quebec | 1,000 | $2 |
| ROYAL BANK OF CANADA | 671 | $1 |
| OPTIMA CAPITAL LLC | 226 | $0 |
| NISA INVESTMENT ADVISORS, LLC | 156 | $0 |
| SBI Securities Co., Ltd. | 100 | $0 |
| SRS Capital Advisors, Inc. | 19 | $0 |