| Bain Capital Life Sciences Investors, LLC | 9,677,125 | $21,193 |
| JENNISON ASSOCIATES LLC | 8,905,699 | $19,503 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,829,758 | $19,337 |
| VANGUARD GROUP INC | 4,419,458 | $9,679 |
| Cormorant Asset Management, LP | 4,400,000 | $9,636 |
| T. Rowe Price Investment Management, Inc. | 4,004,046 | $9 |
| MILLENNIUM MANAGEMENT LLC | 2,736,912 | $5,994 |
| BlackRock, Inc. | 2,328,470 | $5,099 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 2,253,550 | $4,935 |
| TWO SIGMA INVESTMENTS, LP | 1,839,799 | $4,029 |
| RENAISSANCE TECHNOLOGIES LLC | 1,522,583 | $3,334 |
| MORGAN STANLEY | 1,343,708 | $2,943 |
| Woodline Partners LP | 1,250,242 | $2,738 |
| Schonfeld Strategic Advisors LLC | 1,204,070 | $2,637 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,093,959 | $2 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,085,816 | $2,379 |
| MARSHALL WACE, LLP | 959,076 | $2,100 |
| Opaleye Management Inc. | 900,000 | $1,971 |
| Ikarian Capital, LLC | 900,000 | $1,971 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 756,637 | $1,627 |
| TWO SIGMA ADVISERS, LP | 737,900 | $1,616 |
| Burkehill Global Management, LP | 700,000 | $1,533 |
| JANE STREET GROUP, LLC | 662,149 | $1,450 |
| Ensign Peak Advisors, Inc | 550,000 | $1,205 |
| KVP Capital Advisors, LP | 505,431 | $1,107 |
| DIMENSIONAL FUND ADVISORS LP | 452,039 | $990 |
| Raiffeisen Bank International AG | 450,000 | $968 |
| GOLDMAN SACHS GROUP INC | 430,674 | $943 |
| STATE STREET CORP | 425,478 | $932 |
| UBS Group AG | 415,677 | $910 |
| 683 Capital Management, LLC | 388,562 | $851 |
| Almitas Capital LLC | 387,491 | $849 |
| Qube Research & Technologies Ltd | 331,225 | $725 |
| GSA CAPITAL PARTNERS LLP | 303,992 | $1 |
| BOOTHBAY FUND MANAGEMENT, LLC | 243,445 | $533 |
| NORTHERN TRUST CORP | 238,442 | $522 |
| BARCLAYS PLC | 220,696 | $483 |
| Invesco Ltd. | 189,195 | $414 |
| Stonepine Capital Management, LLC | 171,100 | $375 |
| XTX Topco Ltd | 155,387 | $340 |
| Graham Capital Management, L.P. | 151,451 | $332 |
| Squarepoint Ops LLC | 149,094 | $327 |
| Hudson Bay Capital Management LP | 138,729 | $304 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 138,281 | $303 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 130,675 | $286 |
| OMERS ADMINISTRATION Corp | 95,400 | $209 |
| LETKO, BROSSEAU & ASSOCIATES INC | 90,475 | $198 |
| TD Asset Management Inc | 88,600 | $194 |
| CITIGROUP INC | 73,774 | $162 |
| Dynamic Technology Lab Private Ltd | 66,789 | $146 |
| Quadrature Capital Ltd | 66,377 | $145 |
| AMERICAN CENTURY COMPANIES INC | 58,777 | $129 |
| Point72 Asset Management, L.P. | 56,648 | $124 |
| MATAURO, LLC | 55,108 | $121 |
| Bank of New York Mellon Corp | 54,047 | $118 |
| BALYASNY ASSET MANAGEMENT L.P. | 51,552 | $113 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50,824 | $111 |
| Jefferies Financial Group Inc. | 45,125 | $99 |
| LPL Financial LLC | 42,615 | $93 |
| Lighthouse Investment Partners, LLC | 38,880 | $85 |
| CITADEL ADVISORS LLC | 33,502 | $73 |
| SG Americas Securities, LLC | 30,629 | $0 |
| Tower Research Capital LLC (TRC) | 30,345 | $66 |
| FRED ALGER MANAGEMENT, LLC | 28,021 | $61 |
| MERCER GLOBAL ADVISORS INC /ADV | 26,510 | $58 |
| Callan Family Office, LLC | 22,575 | $49 |
| Vanguard Personalized Indexing Management, LLC | 22,384 | $49 |
| JONES FINANCIAL COMPANIES LLLP | 20,660 | $45 |
| Clear Harbor Asset Management, LLC | 19,500 | $43 |
| ANTIPODES PARTNERS Ltd | 17,187 | $38 |
| China Universal Asset Management Co., Ltd. | 15,686 | $34 |
| CRA Financial Services, LLC | 15,000 | $33 |
| Private Advisor Group, LLC | 14,725 | $32 |
| BANK OF AMERICA CORP /DE/ | 14,392 | $32 |
| FMR LLC | 13,045 | $29 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,011 | $28 |
| HB Wealth Management, LLC | 10,000 | $22 |
| JPMORGAN CHASE & CO | 9,805 | $21 |
| Mirae Asset Global Investments Co., Ltd. | 4,678 | $10 |
| PNC Financial Services Group, Inc. | 4,600 | $10 |
| CANADA PENSION PLAN INVESTMENT BOARD | 3,500 | $8 |
| WELLS FARGO & COMPANY/MN | 2,000 | $4 |
| GF FUND MANAGEMENT CO. LTD. | 1,891 | $4 |
| BNP PARIBAS ARBITRAGE, SA | 1,640 | $4 |
| FLAGSHIP HARBOR ADVISORS, LLC | 1,000 | $2 |
| Russell Investments Group, Ltd. | 939 | $2 |
| NISA INVESTMENT ADVISORS, LLC | 811 | $2 |
| Truvestments Capital LLC | 680 | $1 |
| Federation des caisses Desjardins du Quebec | 340 | $1 |
| SBI Securities Co., Ltd. | 316 | $1 |
| ROYAL BANK OF CANADA | 123 | $0 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 60 | $0 |
| Covestor Ltd | 34 | $0 |
| Optiver Holding B.V. | 24 | $0 |
| SRS Capital Advisors, Inc. | 10 | $0 |