CABALETTA BIO INC

Institution	Shares	Value ($000)
Stonepine Capital Management, LLC	171,100	$375
Ikarian Capital, LLC	900,000	$1,971
683 Capital Management, LLC	388,562	$851
Dynamic Technology Lab Private Ltd	66,789	$146
GSA CAPITAL PARTNERS LLP	303,992	$1
MATAURO, LLC	55,108	$121
BOOTHBAY FUND MANAGEMENT, LLC	243,445	$533
Graham Capital Management, L.P.	151,451	$332
Ensign Peak Advisors, Inc	550,000	$1,205
SCHRODER INVESTMENT MANAGEMENT GROUP	756,637	$1,627
LETKO, BROSSEAU & ASSOCIATES INC	90,475	$198
DIMENSIONAL FUND ADVISORS LP	452,039	$990
Hudson Bay Capital Management LP	138,729	$304
OMERS ADMINISTRATION Corp	95,400	$209
Lighthouse Investment Partners, LLC	38,880	$85
Clear Harbor Asset Management, LLC	19,500	$43
China Universal Asset Management Co., Ltd.	15,686	$34
Point72 Asset Management, L.P.	56,648	$124
BALYASNY ASSET MANAGEMENT L.P.	51,552	$113
Callan Family Office, LLC	22,575	$49

Increased Positions (32)

SUPERSTRING CAPITAL MANAGEMENT LP

Value ($000) $4,935 (+36.6%) Shares 2,253,550 (+45.9%)

Opaleye Management Inc.

Value ($000) $1,971 (+4.1%) Shares 900,000 (+11.3%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $4,029 (+266.0%) Shares 1,839,799 (+291.1%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $5,994 (+273.0%) Shares 2,736,912 (+298.5%)

TWO SIGMA ADVISERS, LP

Value ($000) $1,616 (+108.6%) Shares 737,900 (+122.9%)

Raiffeisen Bank International AG

Value ($000) $968 (+16.1%) Shares 450,000 (+28.6%)

BlackRock, Inc.

Value ($000) $5,099 (+34.4%) Shares 2,328,470 (+43.7%)

JENNISON ASSOCIATES LLC

Value ($000) $19,503 (-1.9%) Shares 8,905,699 (+4.8%)

Schonfeld Strategic Advisors LLC

Value ($000) $2,637 (+7.9%) Shares 1,204,070 (+15.3%)

JANE STREET GROUP, LLC

Value ($000) $1,450 (+492.1%) Shares 662,149 (+532.7%)

Qube Research & Technologies Ltd

Value ($000) $725 (+247.7%) Shares 331,225 (+271.5%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $3,334 (+6.4%) Shares 1,522,583 (+13.7%)

BARCLAYS PLC

Value ($000) $483 (+67.5%) Shares 220,696 (+261.0%)

VANGUARD GROUP INC

Value ($000) $9,679 (-1.3%) Shares 4,419,458 (+5.5%)

Squarepoint Ops LLC

Value ($000) $327 (+1075.7%) Shares 149,094 (+1156.3%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $2,379 (+10.4%) Shares 1,085,816 (+18.0%)

GOLDMAN SACHS GROUP INC

Value ($000) $943 (+47.9%) Shares 430,674 (+58.0%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $286 (+27.8%) Shares 130,675 (+36.6%)

Tower Research Capital LLC (TRC)

Value ($000) $66 (+550.3%) Shares 30,345 (+594.9%)

CITIGROUP INC

Value ($000) $162 (+19507.4%) Shares 73,774 (+20858.5%)

Institution	Prev Shares	Curr Shares	Change
SUPERSTRING CAPITAL MANAGEMENT LP	1,544,525	2,253,550	+709,025 (+45.9%)
Opaleye Management Inc.	808,882	900,000	+91,118 (+11.3%)
TWO SIGMA INVESTMENTS, LP	470,475	1,839,799	+1,369,324 (+291.1%)
MILLENNIUM MANAGEMENT LLC	686,813	2,736,912	+2,050,099 (+298.5%)
TWO SIGMA ADVISERS, LP	331,000	737,900	+406,900 (+122.9%)
Raiffeisen Bank International AG	350,000	450,000	+100,000 (+28.6%)
BlackRock, Inc.	1,620,872	2,328,470	+707,598 (+43.7%)
JENNISON ASSOCIATES LLC	8,497,537	8,905,699	+408,162 (+4.8%)
Schonfeld Strategic Advisors LLC	1,044,169	1,204,070	+159,901 (+15.3%)
JANE STREET GROUP, LLC	104,662	662,149	+557,487 (+532.7%)
Qube Research & Technologies Ltd	89,157	331,225	+242,068 (+271.5%)
RENAISSANCE TECHNOLOGIES LLC	1,339,423	1,522,583	+183,160 (+13.7%)
BARCLAYS PLC	61,130	220,696	+159,566 (+261.0%)
VANGUARD GROUP INC	4,190,759	4,419,458	+228,699 (+5.5%)
Squarepoint Ops LLC	11,868	149,094	+137,226 (+1156.3%)
GEODE CAPITAL MANAGEMENT, LLC	920,340	1,085,816	+165,476 (+18.0%)
GOLDMAN SACHS GROUP INC	272,596	430,674	+158,078 (+58.0%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	95,675	130,675	+35,000 (+36.6%)
Tower Research Capital LLC (TRC)	4,367	30,345	+25,978 (+594.9%)
CITIGROUP INC	352	73,774	+73,422 (+20858.5%)

Decreased Positions (18)

Cormorant Asset Management, LP

Value ($000) $9,636 (-17.6%) Shares 4,400,000 (-12.0%)

Woodline Partners LP

Value ($000) $2,738 (-45.2%) Shares 1,250,242 (-41.5%)

XTX Topco Ltd

Value ($000) $340 (-48.8%) Shares 155,387 (-45.3%)

CITADEL ADVISORS LLC

Value ($000) $73 (-95.6%) Shares 33,502 (-95.3%)

MARSHALL WACE, LLP

Value ($000) $2,100 (-32.3%) Shares 959,076 (-27.7%)

JPMORGAN CHASE & CO

Value ($000) $21 (-98.3%) Shares 9,805 (-98.2%)

T. Rowe Price Investment Management, Inc.

Value ($000) $9 (-55.2%) Shares 4,004,046 (-52.1%)

BANK OF AMERICA CORP /DE/

Value ($000) $32 (-95.0%) Shares 14,392 (-94.6%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $303 (-65.2%) Shares 138,281 (-62.8%)

MORGAN STANLEY

Value ($000) $2,943 (-14.7%) Shares 1,343,708 (-8.9%)

ROYAL BANK OF CANADA

Value ($000) $0 (-100.0%) Shares 123 (-99.9%)

FRED ALGER MANAGEMENT, LLC

Value ($000) $61 (-56.2%) Shares 28,021 (-53.2%)

Jefferies Financial Group Inc.

Value ($000) $99 (-11.1%) Shares 45,125 (-5.0%)

FMR LLC

Value ($000) $29 (-13.2%) Shares 13,045 (-7.2%)

WELLS FARGO & COMPANY/MN

Value ($000) $4 (-37.6%) Shares 2,000 (-33.3%)

PRICE T ROWE ASSOCIATES INC /MD/

Value ($000) $2 (-20.9%) Shares 1,093,959 (-15.5%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $4 (-16.2%) Shares 1,640 (-10.4%)

SBI Securities Co., Ltd.

Value ($000) $1 (-35.1%) Shares 316 (-30.7%)

Institution	Prev Shares	Curr Shares	Change
Cormorant Asset Management, LP	5,000,000	4,400,000	-600,000 (-12.0%)
Woodline Partners LP	2,135,348	1,250,242	-885,106 (-41.5%)
XTX Topco Ltd	284,299	155,387	-128,912 (-45.3%)
CITADEL ADVISORS LLC	705,465	33,502	-671,963 (-95.3%)
MARSHALL WACE, LLP	1,326,043	959,076	-366,967 (-27.7%)
JPMORGAN CHASE & CO	537,649	9,805	-527,844 (-98.2%)
T. Rowe Price Investment Management, Inc.	8,362,489	4,004,046	-4,358,443 (-52.1%)
BANK OF AMERICA CORP /DE/	268,058	14,392	-253,666 (-94.6%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	372,108	138,281	-233,827 (-62.8%)
MORGAN STANLEY	1,474,676	1,343,708	-130,968 (-8.9%)
ROYAL BANK OF CANADA	91,723	123	-91,600 (-99.9%)
FRED ALGER MANAGEMENT, LLC	59,813	28,021	-31,792 (-53.2%)
Jefferies Financial Group Inc.	47,500	45,125	-2,375 (-5.0%)
FMR LLC	14,064	13,045	-1,019 (-7.2%)
WELLS FARGO & COMPANY/MN	3,000	2,000	-1,000 (-33.3%)
PRICE T ROWE ASSOCIATES INC /MD/	1,294,949	1,093,959	-200,990 (-15.5%)
BNP PARIBAS ARBITRAGE, SA	1,831	1,640	-191 (-10.4%)
SBI Securities Co., Ltd.	456	316	-140 (-30.7%)

Exited Positions (9)

HEIGHTS CAPITAL MANAGEMENT, INC

Value ($000) $4,877 Shares 2,084,202

Alyeska Investment Group, L.P.

Value ($000) $3,042 Shares 1,300,000

Rangeley Capital, LLC

Value ($000) $26 Shares 11,300

nVerses Capital, LLC

Value ($000) $14 Shares 3,000

Caitong International Asset Management Co., Ltd

Value ($000) $21 Shares 8,983

FEDERATED HERMES, INC.

Value ($000) $262 Shares 112,028

Susquehanna Portfolio Strategies, LLC

Value ($000) $79 Shares 33,937

Rise Advisors, LLC

Value ($000) $3 Shares 1,083

ACADIAN ASSET MANAGEMENT LLC

Value ($000) $0 Shares 186,521

Institution	Prev Shares	Prev Value ($000)
HEIGHTS CAPITAL MANAGEMENT, INC	2,084,202	$4,877
Alyeska Investment Group, L.P.	1,300,000	$3,042
Rangeley Capital, LLC	11,300	$26
nVerses Capital, LLC	3,000	$14
Caitong International Asset Management Co., Ltd	8,983	$21
FEDERATED HERMES, INC.	112,028	$262
Susquehanna Portfolio Strategies, LLC	33,937	$79
Rise Advisors, LLC	1,083	$3
ACADIAN ASSET MANAGEMENT LLC	186,521	$0