| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | $499,279 |
| Avoro Capital Advisors LLC | 14,555,555 | $364,034 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 11,281,741 | $282,156 |
| Index Venture Life Associates VI Ltd | 9,961,789 | $249,144 |
| FMR LLC | 8,961,939 | $224,138 |
| GENERAL ATLANTIC, L.P. | 6,117,715 | $153,004 |
| FARALLON CAPITAL MANAGEMENT LLC | 5,377,068 | $134,480 |
| TCG Crossover Management, LLC | 4,286,480 | $107,205 |
| JANUS HENDERSON GROUP PLC | 4,093,608 | $102,393 |
| Siren, L.L.C. | 4,027,517 | $100,728 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,927,343 | $98 |
| EcoR1 Capital, LLC | 3,115,000 | $77,906 |
| PERCEPTIVE ADVISORS LLC | 2,917,634 | $72,970 |
| FRANKLIN RESOURCES INC | 2,368,381 | $59,233 |
| FEDERATED HERMES, INC. | 2,342,139 | $58,577 |
| First Light Asset Management, LLC | 2,278,940 | $56,996 |
| BRAIDWELL LP | 2,188,320 | $54,730 |
| Deep Track Capital, LP | 2,000,000 | $50,020 |
| MILLENNIUM MANAGEMENT LLC | 1,870,671 | $46,785 |
| RTW INVESTMENTS, LP | 1,790,837 | $44,789 |
| MAVERICK CAPITAL LTD | 1,643,724 | $41,110 |
| Foresite Capital Management VI LLC | 1,364,019 | $34,114 |
| Cormorant Asset Management, LP | 1,325,000 | $33,138 |
| Capital World Investors | 1,158,699 | $28,979 |
| STEMPOINT CAPITAL LP | 1,154,114 | $28,864 |
| AMERICAN CENTURY COMPANIES INC | 1,129,758 | $28,255 |
| MORGAN STANLEY | 1,109,098 | $27,739 |
| Sofinnova Investments, Inc. | 1,104,274 | $27,618 |
| Commodore Capital LP | 1,000,000 | $25,010 |
| BANK OF AMERICA CORP /DE/ | 949,544 | $23,748 |
| Jain Global LLC | 915,803 | $22,904 |
| D. E. Shaw & Co., Inc. | 831,636 | $20,799 |
| GOLDMAN SACHS GROUP INC | 779,001 | $19,483 |
| Octagon Capital Advisors LP | 750,000 | $18,758 |
| BAKER BROS. ADVISORS LP | 670,751 | $16,775 |
| Affinity Asset Advisors, LLC | 600,552 | $15,020 |
| BlackRock, Inc. | 592,604 | $14,821 |
| PFM Health Sciences, LP | 591,601 | $14,796 |
| 5AM Venture Management, LLC | 580,945 | $14,529 |
| Woodline Partners LP | 578,251 | $14,462 |
| UBS Group AG | 537,518 | $13,443 |
| CITADEL ADVISORS LLC | 519,962 | $13,004 |
| ARMISTICE CAPITAL, LLC | 500,000 | $12,505 |
| JANE STREET GROUP, LLC | 480,204 | $12,010 |
| BALYASNY ASSET MANAGEMENT L.P. | 468,815 | $11,725 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 458,203 | $11,460 |
| Walleye Capital LLC | 441,160 | $11,033 |
| Candriam S.C.A. | 395,623 | $9,895 |
| Qube Research & Technologies Ltd | 378,740 | $9,472 |
| TD Asset Management Inc | 376,344 | $9,412 |
| ROYCE & ASSOCIATES LP | 362,873 | $9,075 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 348,279 | $8,710 |
| SummitTX Capital, L.P. | 332,708 | $8,321 |
| Rock Springs Capital Management LP | 324,015 | $8,104 |
| Saturn V Capital Management LP | 282,692 | $7,070 |
| AMERIPRISE FINANCIAL INC | 280,120 | $7,006 |
| RENAISSANCE TECHNOLOGIES LLC | 279,300 | $6,985 |
| SG Americas Securities, LLC | 263,625 | $7 |
| WCM INVESTMENT MANAGEMENT, LLC | 257,190 | $6,363 |
| Nantahala Capital Management, LLC | 254,803 | $6,373 |
| HighMark Wealth Management LLC | 236,785 | $5,922 |
| MARSHALL WACE, LLP | 216,130 | $5,405 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 211,253 | $5,230 |
| Logos Global Management LP | 200,000 | $5,002 |
| FRED ALGER MANAGEMENT, LLC | 162,147 | $4,055 |
| DEUTSCHE BANK AG\ | 156,205 | $3,907 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 155,101 | $3,879 |
| Burkehill Global Management, LP | 150,000 | $3,752 |
| Trexquant Investment LP | 146,523 | $3,665 |
| Blue Owl Capital Holdings LP | 139,450 | $3,488 |
| TUDOR INVESTMENT CORP ET AL | 121,810 | $3,046 |
| Legal & General Group Plc | 105,427 | $2,637 |
| Eagle Health Investments LP | 103,100 | $2,579 |
| Holocene Advisors, LP | 101,597 | $2,541 |
| Rhenman & Partners Asset Management AB | 100,000 | $2,501 |
| Verition Fund Management LLC | 94,912 | $2,374 |
| DIADEMA PARTNERS LP | 90,000 | $2,251 |
| GEODE CAPITAL MANAGEMENT, LLC | 87,610 | $2,191 |
| Squarepoint Ops LLC | 81,812 | $2,046 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 81,525 | $2,039 |
| JPMORGAN CHASE & CO | 81,486 | $2,038 |
| XTX Topco Ltd | 79,077 | $1,978 |
| Voleon Capital Management LP | 79,074 | $1,978 |
| Spruce Street Capital LP | 77,997 | $1,951 |
| Russell Investments Group, Ltd. | 74,819 | $1,871 |
| Cinctive Capital Management LP | 72,831 | $1,822 |
| Aquatic Capital Management LLC | 69,755 | $1,745 |
| TWO SIGMA INVESTMENTS, LP | 57,444 | $1,437 |
| WELLINGTON MANAGEMENT GROUP LLP | 50,180 | $1,255 |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $1,251 |
| HighVista Strategies LLC | 44,490 | $1,113 |
| Persistent Asset Partners Ltd | 43,266 | $1,082 |
| ADAR1 Capital Management, LLC | 38,566 | $965 |
| B. Metzler seel. Sohn & Co. AG | 38,432 | $961 |
| GSA CAPITAL PARTNERS LLP | 33,104 | $1 |
| BOOTHBAY FUND MANAGEMENT, LLC | 32,508 | $813 |
| Voya Investment Management LLC | 29,670 | $742 |
| PSP Research LLC | 21,879 | $547 |
| Atom Investors LP | 18,347 | $459 |
| Meridian Wealth Partners, LLC | 18,101 | $453 |
| 46 other institutions | 208,338 | $4,672 |