| TANG CAPITAL MANAGEMENT LLC | 16,790,809 | $90,167 |
| ORBIMED ADVISORS LLC | 15,219,994 | $81,731 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,182,379 | $76,159 |
| Vivo Capital, LLC | 9,545,466 | $51,259 |
| BlackRock, Inc. | 9,388,624 | $50,417 |
| VANGUARD GROUP INC | 8,048,374 | $43,220 |
| Enavate Sciences GP, LLC | 7,788,150 | $41,822 |
| BVF INC/IL | 7,764,842 | $41,697 |
| Blackstone Inc. | 6,126,182 | $32,898 |
| STATE STREET CORP | 4,890,525 | $26,262 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,436,500 | $23,824 |
| Rock Springs Capital Management LP | 3,927,202 | $21,089 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,606,000 | $19,364 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,502,526 | $18,813 |
| Blue Owl Capital Holdings LP | 3,466,525 | $18,615 |
| Sofinnova Investments, Inc. | 3,365,446 | $18,072 |
| MILLENNIUM MANAGEMENT LLC | 3,109,286 | $16,697 |
| BRAIDWELL LP | 2,786,778 | $14,965 |
| FMR LLC | 2,579,711 | $13,853 |
| Palo Alto Investors LP | 2,532,419 | $13,599 |
| RTW INVESTMENTS, LP | 2,500,000 | $13,425 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,593,275 | $8,556 |
| Birchview Capital, LP | 1,592,938 | $8,554 |
| GOLDMAN SACHS GROUP INC | 1,517,415 | $8,149 |
| Trails Edge Capital Partners, LP | 1,415,273 | $7,600 |
| MARSHALL WACE, LLP | 1,263,647 | $6,786 |
| Logos Global Management LP | 1,150,000 | $6,176 |
| NEXTBio Capital Management LP | 1,114,005 | $5,982 |
| ACUTA CAPITAL PARTNERS, LLC | 1,093,300 | $5,871 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,051,343 | $5,646 |
| Monashee Investment Management LLC | 1,000,000 | $5,370 |
| NORTHERN TRUST CORP | 972,935 | $5,225 |
| JPMORGAN CHASE & CO | 870,014 | $4,672 |
| AMERIPRISE FINANCIAL INC | 823,174 | $4,420 |
| Ikarian Capital, LLC | 800,000 | $4,296 |
| Burkehill Global Management, LP | 700,000 | $3,759 |
| BARCLAYS PLC | 594,776 | $3,194 |
| HealthInvest Partners AB | 584,332 | $3,138 |
| Seven Fleet Capital Management LP | 568,747 | $3,054 |
| Y-Intercept (Hong Kong) Ltd | 462,166 | $2,482 |
| Schonfeld Strategic Advisors LLC | 452,442 | $2,430 |
| Qube Research & Technologies Ltd | 441,805 | $2,372 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 410,157 | $2,203 |
| MORGAN STANLEY | 365,245 | $1,961 |
| DIMENSIONAL FUND ADVISORS LP | 341,596 | $1,835 |
| WELLINGTON MANAGEMENT GROUP LLP | 316,849 | $1,701 |
| PRUDENTIAL FINANCIAL INC | 314,750 | $1,690 |
| Bank of New York Mellon Corp | 312,480 | $1,678 |
| Nuveen, LLC | 288,924 | $1,552 |
| ROYCE & ASSOCIATES LP | 285,988 | $1,536 |
| BANK OF AMERICA CORP /DE/ | 266,434 | $1,431 |
| CITIGROUP INC | 261,876 | $1,406 |
| HighVista Strategies LLC | 245,532 | $1,319 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 210,249 | $1,129 |
| BOOTHBAY FUND MANAGEMENT, LLC | 205,024 | $1,101 |
| Connor, Clark & Lunn Investment Management Ltd. | 191,724 | $1,030 |
| STATE OF WISCONSIN INVESTMENT BOARD | 185,423 | $996 |
| UBS Group AG | 167,856 | $901 |
| AQR CAPITAL MANAGEMENT LLC | 155,218 | $834 |
| Rafferty Asset Management, LLC | 151,743 | $815 |
| ALPS ADVISORS INC | 146,040 | $784 |
| WELLS FARGO & COMPANY/MN | 144,798 | $778 |
| ADAR1 Capital Management, LLC | 139,000 | $746 |
| RHUMBLINE ADVISERS | 134,605 | $723 |
| GSA CAPITAL PARTNERS LLP | 133,810 | $1 |
| Squarepoint Ops LLC | 126,192 | $678 |
| Brevan Howard Capital Management LP | 118,528 | $636 |
| XTX Topco Ltd | 115,634 | $621 |
| DEUTSCHE BANK AG\ | 109,273 | $587 |
| Creative Planning | 108,144 | $581 |
| SG Americas Securities, LLC | 106,533 | $1 |
| CITADEL ADVISORS LLC | 105,682 | $568 |
| NEOS Investment Management LLC | 101,676 | $546 |
| TEMA ETFS LLC | 100,176 | $538 |
| CM Management, LLC | 100,000 | $537 |
| ALLIANCEBERNSTEIN L.P. | 83,940 | $451 |
| SummitTX Capital, L.P. | 81,449 | $437 |
| RAYMOND JAMES FINANCIAL INC | 80,142 | $430 |
| Atom Investors LP | 77,281 | $415 |
| MetLife Investment Management, LLC | 73,985 | $397 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 70,488 | $0 |
| JANE STREET GROUP, LLC | 70,063 | $376 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69,576 | $374 |
| FRANKLIN RESOURCES INC | 66,607 | $358 |
| Invesco Ltd. | 63,901 | $343 |
| Persistent Asset Partners Ltd | 57,253 | $307 |
| PROFUND ADVISORS LLC | 57,246 | $307 |
| Graham Capital Management, L.P. | 53,427 | $287 |
| Virtus Investment Advisers, LLC | 51,556 | $277 |
| D. E. Shaw & Co., Inc. | 51,482 | $276 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,742 | $240 |
| LPL Financial LLC | 44,470 | $239 |
| AXQ CAPITAL, LP | 41,378 | $222 |
| AMERICAN CENTURY COMPANIES INC | 40,412 | $217 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,325 | $217 |
| INTECH INVESTMENT MANAGEMENT LLC | 38,936 | $209 |
| Police & Firemen's Retirement System of New Jersey | 35,503 | $191 |
| SmartHarvest Portfolios, LLC | 34,715 | $186 |
| Simplicity Wealth,LLC | 33,869 | $182 |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,407 | $163 |
| 69 other institutions | 619,108 | $3,185 |