| ORBIMED ADVISORS LLC | 7,165,006 | $55,171 |
| BlackRock, Inc. | 5,056,361 | $38,934 |
| VANGUARD GROUP INC | 3,873,482 | $29,826 |
| MORGAN STANLEY | 3,567,908 | $27,473 |
| ADAMS STREET PARTNERS LLC | 3,275,616 | $25,222 |
| Point72 Asset Management, L.P. | 2,875,000 | $22,138 |
| STATE STREET CORP | 2,788,223 | $21,469 |
| MPM BioImpact LLC | 2,743,671 | $21,126 |
| Vivo Capital, LLC | 2,234,566 | $17,206 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,473,026 | $11,345 |
| Foresite Capital Management VI LLC | 1,381,233 | $10,635 |
| DCF Advisers, LLC | 729,000 | $5,613 |
| PERCEPTIVE ADVISORS LLC | 692,441 | $5,332 |
| MILLENNIUM MANAGEMENT LLC | 688,770 | $5,304 |
| GOLDMAN SACHS GROUP INC | 553,327 | $4,261 |
| Logos Global Management LP | 500,000 | $3,850 |
| ADAR1 Capital Management, LLC | 465,875 | $3,587 |
| RTW INVESTMENTS, LP | 447,607 | $3,447 |
| NORTHERN TRUST CORP | 429,771 | $3,309 |
| SPHERA FUNDS MANAGEMENT LTD. | 407,709 | $3,139 |
| BARCLAYS PLC | 394,766 | $3,040 |
| JANE STREET GROUP, LLC | 378,297 | $2,913 |
| WELLINGTON MANAGEMENT GROUP LLP | 314,683 | $2,423 |
| BANK OF AMERICA CORP /DE/ | 236,495 | $1,821 |
| MARSHALL WACE, LLP | 216,248 | $1,665 |
| UBS Group AG | 212,006 | $1,632 |
| CITADEL ADVISORS LLC | 208,182 | $1,603 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 171,173 | $1,318 |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 167,400 | $1,289 |
| FRED ALGER MANAGEMENT, LLC | 144,381 | $1,112 |
| TWO SIGMA INVESTMENTS, LP | 143,598 | $1,106 |
| TOWERVIEW LLC | 140,000 | $1,078 |
| Bank of New York Mellon Corp | 131,628 | $1,014 |
| RAYMOND JAMES FINANCIAL INC | 121,157 | $933 |
| Qube Research & Technologies Ltd | 114,500 | $882 |
| Squarepoint Ops LLC | 104,820 | $807 |
| Rafferty Asset Management, LLC | 99,724 | $768 |
| ExodusPoint Capital Management, LP | 86,720 | $668 |
| NEOS Investment Management LLC | 80,893 | $623 |
| TEMA ETFS LLC | 79,698 | $614 |
| RHUMBLINE ADVISERS | 70,727 | $545 |
| Nuveen, LLC | 68,064 | $524 |
| OSAIC HOLDINGS, INC. | 67,993 | $524 |
| D. E. Shaw & Co., Inc. | 64,915 | $500 |
| JACKSON SQUARE CAPITAL, LLC | 63,773 | $491 |
| WELLS FARGO & COMPANY/MN | 62,623 | $482 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,754 | $476 |
| ALPS ADVISORS INC | 61,318 | $472 |
| HSBC HOLDINGS PLC | 59,269 | $451 |
| DEUTSCHE BANK AG\ | 56,039 | $432 |
| Hikari Power Ltd | 49,959 | $0 |
| Caption Management, LLC | 49,325 | $380 |
| Ancora Advisors LLC | 47,667 | $367 |
| Invesco Ltd. | 43,583 | $336 |
| Creative Planning | 39,178 | $302 |
| PROFUND ADVISORS LLC | 37,063 | $285 |
| INTECH INVESTMENT MANAGEMENT LLC | 35,973 | $277 |
| AlphaQuest LLC | 35,972 | $277 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 34,105 | $0 |
| AVITY INVESTMENT MANAGEMENT INC. | 32,680 | $252 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,409 | $248 |
| Virtus Investment Advisers, LLC | 31,783 | $245 |
| MetLife Investment Management, LLC | 30,782 | $237 |
| JPMORGAN CHASE & CO | 30,655 | $236 |
| Argent Advisors, Inc. | 30,000 | $231 |
| Connor, Clark & Lunn Investment Management Ltd. | 28,117 | $217 |
| Voya Investment Management LLC | 27,661 | $213 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 26,700 | $206 |
| GROUP ONE TRADING, L.P. | 26,667 | $205 |
| Palumbo Wealth Management LLC | 26,255 | $202 |
| BALYASNY ASSET MANAGEMENT L.P. | 25,031 | $193 |
| DRW Securities, LLC | 23,384 | $180 |
| Three Bridge Wealth Advisors, LLC | 22,371 | $172 |
| Verition Fund Management LLC | 21,382 | $165 |
| SG Americas Securities, LLC | 20,021 | $0 |
| COMMERCE BANK | 20,000 | $154 |
| Graham Capital Management, L.P. | 19,274 | $148 |
| TWO SIGMA ADVISERS, LP | 18,900 | $146 |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,800 | $145 |
| China Universal Asset Management Co., Ltd. | 18,169 | $140 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,497 | $135 |
| ALLIANCEBERNSTEIN L.P. | 17,120 | $132 |
| Sowell Financial Services LLC | 17,000 | $131 |
| SHELTON WEALTH MANAGEMENT, LLC | 15,638 | $120 |
| Police & Firemen's Retirement System of New Jersey | 15,530 | $120 |
| CITIGROUP INC | 14,858 | $114 |
| GSA CAPITAL PARTNERS LLP | 14,188 | $0 |
| ProShare Advisors LLC | 13,764 | $106 |
| AXQ CAPITAL, LP | 12,601 | $97 |
| FOX RUN MANAGEMENT, L.L.C. | 11,220 | $86 |
| WHITTIER TRUST CO OF NEVADA INC | 11,200 | $75 |
| CAPTRUST FINANCIAL ADVISORS | 11,051 | $85 |
| Truvestments Capital LLC | 10,257 | $79 |
| OneDigital Investment Advisors LLC | 10,000 | $77 |
| ROTHSCHILD INVESTMENT LLC | 7,000 | $54 |
| Russell Investments Group, Ltd. | 6,661 | $51 |
| BNP PARIBAS ARBITRAGE, SA | 6,566 | $51 |
| Legal & General Group Plc | 5,787 | $45 |
| Ameritas Investment Partners, Inc. | 5,348 | $41 |
| Mirae Asset Global Investments Co., Ltd. | 3,629 | $28 |
| 24 other institutions | 20,587 | $141 |