CORVUS PHARMACEUTICALS INC

Institution	Shares	Value ($000)
MPM BioImpact LLC	2,743,671	$21,126
DCF Advisers, LLC	729,000	$5,613
ADAR1 Capital Management, LLC	465,875	$3,587
Logos Global Management LP	500,000	$3,850
AlphaQuest LLC	35,972	$277
FOX RUN MANAGEMENT, L.L.C.	11,220	$86
PROFUND ADVISORS LLC	37,063	$285
MILLENNIUM MANAGEMENT LLC	688,770	$5,304
ExodusPoint Capital Management, LP	86,720	$668
FRED ALGER MANAGEMENT, LLC	144,381	$1,112
MARSHALL WACE, LLP	216,248	$1,665
Rafferty Asset Management, LLC	99,724	$768
ALPS ADVISORS INC	61,318	$472
DRW Securities, LLC	23,384	$180
Qube Research & Technologies Ltd	114,500	$882
Squarepoint Ops LLC	104,820	$807
Graham Capital Management, L.P.	19,274	$148
SUSQUEHANNA INTERNATIONAL GROUP, LLP	61,754	$476
Connor, Clark & Lunn Investment Management Ltd.	28,117	$217
Verition Fund Management LLC	21,382	$165

Increased Positions (38)

TEMA ETFS LLC

Value ($000) $614 (+40.6%) Shares 79,698 (+34.6%)

MORGAN STANLEY

Value ($000) $27,473 (+503.9%) Shares 3,567,908 (+478.1%)

STATE STREET CORP

Value ($000) $21,469 (+189.5%) Shares 2,788,223 (+177.1%)

Virtus Investment Advisers, LLC

Value ($000) $245 (+23.7%) Shares 31,783 (+18.4%)

BARCLAYS PLC

Value ($000) $3,040 (+60793860.0%) Shares 394,766 (+39476500.0%)

VANGUARD GROUP INC

Value ($000) $29,826 (+16.6%) Shares 3,873,482 (+11.6%)

JANE STREET GROUP, LLC

Value ($000) $2,913 (+480.7%) Shares 378,297 (+455.8%)

BlackRock, Inc.

Value ($000) $38,934 (+12.2%) Shares 5,056,361 (+7.3%)

Truvestments Capital LLC

Value ($000) $79 (+94.4%) Shares 10,257 (+86.1%)

CITADEL ADVISORS LLC

Value ($000) $1,603 (+408.6%) Shares 208,182 (+386.8%)

WELLINGTON MANAGEMENT GROUP LLP

Value ($000) $2,423 (+82.5%) Shares 314,683 (+74.7%)

Palumbo Wealth Management LLC

Value ($000) $202 (+16.2%) Shares 26,255 (+11.2%)

SHELTON WEALTH MANAGEMENT, LLC

Value ($000) $120 (+18.9%) Shares 15,638 (+13.8%)

GOLDMAN SACHS GROUP INC

Value ($000) $4,261 (+29.7%) Shares 553,327 (+24.2%)

BANK OF AMERICA CORP /DE/

Value ($000) $1,821 (+62.6%) Shares 236,495 (+55.6%)

Caption Management, LLC

Value ($000) $380 (+136.1%) Shares 49,325 (+126.0%)

UBS Group AG

Value ($000) $1,632 (+36.7%) Shares 212,006 (+30.8%)

NEOS Investment Management LLC

Value ($000) $623 (+42.8%) Shares 80,893 (+36.6%)

China Universal Asset Management Co., Ltd.

Value ($000) $140 (+45.3%) Shares 18,169 (+39.1%)

D. E. Shaw & Co., Inc.

Value ($000) $500 (+165.2%) Shares 64,915 (+153.8%)

Institution	Prev Shares	Curr Shares	Change
TEMA ETFS LLC	59,202	79,698	+20,496 (+34.6%)
MORGAN STANLEY	617,224	3,567,908	+2,950,684 (+478.1%)
STATE STREET CORP	1,006,319	2,788,223	+1,781,904 (+177.1%)
Virtus Investment Advisers, LLC	26,837	31,783	+4,946 (+18.4%)
BARCLAYS PLC	1	394,766	+394,765 (+39476500.0%)
VANGUARD GROUP INC	3,471,925	3,873,482	+401,557 (+11.6%)
JANE STREET GROUP, LLC	68,066	378,297	+310,231 (+455.8%)
BlackRock, Inc.	4,710,442	5,056,361	+345,919 (+7.3%)
Truvestments Capital LLC	5,513	10,257	+4,744 (+86.1%)
CITADEL ADVISORS LLC	42,766	208,182	+165,416 (+386.8%)
WELLINGTON MANAGEMENT GROUP LLP	180,175	314,683	+134,508 (+74.7%)
Palumbo Wealth Management LLC	23,614	26,255	+2,641 (+11.2%)
SHELTON WEALTH MANAGEMENT, LLC	13,742	15,638	+1,896 (+13.8%)
GOLDMAN SACHS GROUP INC	445,670	553,327	+107,657 (+24.2%)
BANK OF AMERICA CORP /DE/	151,966	236,495	+84,529 (+55.6%)
Caption Management, LLC	21,827	49,325	+27,498 (+126.0%)
UBS Group AG	162,074	212,006	+49,932 (+30.8%)
NEOS Investment Management LLC	59,202	80,893	+21,691 (+36.6%)
China Universal Asset Management Co., Ltd.	13,061	18,169	+5,108 (+39.1%)
D. E. Shaw & Co., Inc.	25,575	64,915	+39,340 (+153.8%)

Decreased Positions (28)

Foresite Capital Management VI LLC

Value ($000) $10,635 (-16.6%) Shares 1,381,233 (-20.2%)

TOWERVIEW LLC

Value ($000) $1,078 (-14.0%) Shares 140,000 (-17.6%)

RTW INVESTMENTS, LP

Value ($000) $3,447 (-82.5%) Shares 447,607 (-83.3%)

PERCEPTIVE ADVISORS LLC

Value ($000) $5,332 (-49.7%) Shares 692,441 (-51.9%)

GSA CAPITAL PARTNERS LLP

Value ($000) $0 (-96.3%) Shares 14,188 (-96.5%)

Point72 Asset Management, L.P.

Value ($000) $22,138 (-53.5%) Shares 2,875,000 (-55.5%)

AXQ CAPITAL, LP

Value ($000) $97 (-51.3%) Shares 12,601 (-53.4%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $206 (-58.2%) Shares 26,700 (-60.0%)

TWO SIGMA ADVISERS, LP

Value ($000) $146 (-87.8%) Shares 18,900 (-88.3%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $1,106 (-26.2%) Shares 143,598 (-29.4%)

ROYAL BANK OF CANADA

Value ($000) $12 (-97.3%) Shares 1,622 (-97.3%)

NORTHERN TRUST CORP

Value ($000) $3,309 (-3.7%) Shares 429,771 (-7.9%)

HSBC HOLDINGS PLC

Value ($000) $451 (-23.1%) Shares 59,269 (-28.1%)

RHUMBLINE ADVISERS

Value ($000) $545 (-10.5%) Shares 70,727 (-14.4%)

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

Value ($000) $1,318 (+0.6%) Shares 171,173 (-3.7%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $51 (-45.2%) Shares 6,566 (-47.5%)

RAYMOND JAMES FINANCIAL INC

Value ($000) $933 (+1.7%) Shares 121,157 (-2.7%)

MetLife Investment Management, LLC

Value ($000) $237 (-4.3%) Shares 30,782 (-8.4%)

Empirical Financial Services, LLC d.b.a. Empirical Wealth Management

Value ($000) $1,289 (+3.4%) Shares 167,400 (-1.1%)

Tower Research Capital LLC (TRC)

Value ($000) $5 (-73.5%) Shares 631 (-74.6%)

Institution	Prev Shares	Curr Shares	Change
Foresite Capital Management VI LLC	1,731,233	1,381,233	-350,000 (-20.2%)
TOWERVIEW LLC	170,000	140,000	-30,000 (-17.6%)
RTW INVESTMENTS, LP	2,679,479	447,607	-2,231,872 (-83.3%)
PERCEPTIVE ADVISORS LLC	1,438,595	692,441	-746,154 (-51.9%)
GSA CAPITAL PARTNERS LLP	401,407	14,188	-387,219 (-96.5%)
Point72 Asset Management, L.P.	6,454,274	2,875,000	-3,579,274 (-55.5%)
AXQ CAPITAL, LP	27,051	12,601	-14,450 (-53.4%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	66,700	26,700	-40,000 (-60.0%)
TWO SIGMA ADVISERS, LP	161,600	18,900	-142,700 (-88.3%)
TWO SIGMA INVESTMENTS, LP	203,360	143,598	-59,762 (-29.4%)
ROYAL BANK OF CANADA	60,843	1,622	-59,221 (-97.3%)
NORTHERN TRUST CORP	466,486	429,771	-36,715 (-7.9%)
HSBC HOLDINGS PLC	82,387	59,269	-23,118 (-28.1%)
RHUMBLINE ADVISERS	82,590	70,727	-11,863 (-14.4%)
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	177,788	171,173	-6,615 (-3.7%)
BNP PARIBAS ARBITRAGE, SA	12,516	6,566	-5,950 (-47.5%)
RAYMOND JAMES FINANCIAL INC	124,496	121,157	-3,339 (-2.7%)
MetLife Investment Management, LLC	33,594	30,782	-2,812 (-8.4%)
Empirical Financial Services, LLC d.b.a. Empirical Wealth Management	169,200	167,400	-1,800 (-1.1%)
Tower Research Capital LLC (TRC)	2,487	631	-1,856 (-74.6%)

Exited Positions (7)

STEMPOINT CAPITAL LP

Value ($000) $711 Shares 96,439

PKS Advisory Services, LLC

Value ($000) $77 Shares 10,500

Quarry LP

Value ($000) $27 Shares 3,653

Jain Global LLC

Value ($000) $204 Shares 27,618

Brevan Howard Capital Management LP

Value ($000) $113 Shares 15,300

Trexquant Investment LP

Value ($000) $90 Shares 12,226

Aquatic Capital Management LLC

Value ($000) $0 Shares 55

Institution	Prev Shares	Prev Value ($000)
STEMPOINT CAPITAL LP	96,439	$711
PKS Advisory Services, LLC	10,500	$77
Quarry LP	3,653	$27
Jain Global LLC	27,618	$204
Brevan Howard Capital Management LP	15,300	$113
Trexquant Investment LP	12,226	$90
Aquatic Capital Management LLC	55	$0