CRINETICS PHARMACEUTICALS IN

Ticker: CRNX CUSIP: 22663K107 Class: EQTY

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,507,636 Value ($000) $70,180 Avg Close $44.52 Range $38.81 - $50.98

Q3 2025

Shares 1,688,611 Value ($000) $70,331 Avg Close $31.97 Range $25.83 - $47.41

Q2 2025

Shares 1,688,611 Value ($000) $48,564 Avg Close $30.88 Range $24.10 - $34.68

Q1 2025

Shares 1,688,611 Value ($000) $56,636 Avg Close $37.35 Range $31.65 - $53.55

Q4 2024

Shares 1,609,652 Value ($000) $82,302 Avg Close $55.95 Range $49.48 - $62.53

Q3 2024

Shares 1,309,652 Value ($000) $66,923 Avg Close $51.57 Range $43.71 - $55.78

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,507,636	$70,180	$44.52	$38.81 - $50.98
Q3 2025	1,688,611	$70,331	$31.97	$25.83 - $47.41
Q2 2025	1,688,611	$48,564	$30.88	$24.10 - $34.68
Q1 2025	1,688,611	$56,636	$37.35	$31.65 - $53.55
Q4 2024	1,609,652	$82,302	$55.95	$49.48 - $62.53
Q3 2024	1,309,652	$66,923	$51.57	$43.71 - $55.78