| FMR LLC | 14,293,775 | $665,375 |
| VANGUARD GROUP INC | 9,135,504 | $425,258 |
| WELLINGTON MANAGEMENT GROUP LLP | 8,037,889 | $374,164 |
| BlackRock, Inc. | 7,988,548 | $371,867 |
| FARALLON CAPITAL MANAGEMENT LLC | 6,933,098 | $322,736 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,387,740 | $297,349 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,224,387 | $243 |
| JANUS HENDERSON GROUP PLC | 4,440,691 | $206,604 |
| EcoR1 Capital, LLC | 4,288,120 | $199,612 |
| Point72 Asset Management, L.P. | 2,337,034 | $108,789 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,242,631 | $104,411 |
| Paradigm Biocapital Advisors LP | 2,210,774 | $102,912 |
| STATE STREET CORP | 2,161,378 | $100,612 |
| BAKER BROS. ADVISORS LP | 1,648,869 | $76,755 |
| Novo Holdings A/S | 1,625,000 | $75,644 |
| Pictet Asset Management Holding SA | 1,560,300 | $72,632 |
| Siren, L.L.C. | 1,507,636 | $70,180 |
| GW&K Investment Management, LLC | 1,476,325 | $69 |
| RTW INVESTMENTS, LP | 1,351,326 | $62,904 |
| BNP Paribas Investment Partners S.A. | 1,327,382 | $62 |
| JENNISON ASSOCIATES LLC | 1,281,601 | $59,659 |
| First Light Asset Management, LLC | 1,194,263 | $55,593 |
| JPMORGAN CHASE & CO | 1,154,710 | $53,752 |
| AMERICAN CENTURY COMPANIES INC | 1,068,878 | $49,756 |
| ORBIMED ADVISORS LLC | 999,000 | $46,503 |
| UBS Group AG | 908,192 | $42,276 |
| Hood River Capital Management LLC | 897,403 | $41,774 |
| Candriam S.C.A. | 830,961 | $38,683 |
| BANK OF AMERICA CORP /DE/ | 801,314 | $37,301 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 781,981 | $36,401 |
| NORTHERN TRUST CORP | 769,823 | $35,835 |
| MORGAN STANLEY | 768,826 | $35,789 |
| Fisher Asset Management, LLC | 758,659 | $35,316 |
| abrdn plc | 674,533 | $31,400 |
| AMERIPRISE FINANCIAL INC | 601,190 | $27,985 |
| Fiera Capital Corp | 578,455 | $26,927 |
| GOLDMAN SACHS GROUP INC | 567,127 | $26,400 |
| DIMENSIONAL FUND ADVISORS LP | 548,977 | $25,556 |
| Nuveen, LLC | 522,466 | $24,321 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 408,312 | $19,007 |
| Bank of New York Mellon Corp | 405,010 | $18,853 |
| ADAR1 Capital Management, LLC | 309,368 | $14,401 |
| Voya Investment Management LLC | 302,001 | $14,058 |
| MILLENNIUM MANAGEMENT LLC | 300,335 | $13,981 |
| Cormorant Asset Management, LP | 300,000 | $13,965 |
| Ensign Peak Advisors, Inc | 275,616 | $12,830 |
| Impax Asset Management Group plc | 275,000 | $12,801 |
| Prosight Management, LP | 262,904 | $12,238 |
| CITADEL ADVISORS LLC | 254,720 | $11,857 |
| DEUTSCHE BANK AG\ | 235,018 | $10,940 |
| BALYASNY ASSET MANAGEMENT L.P. | 233,197 | $10,855 |
| UBS ASSET MANAGEMENT AMERICAS INC | 225,842 | $10,513 |
| GordonMD Global Investments LP | 224,135 | $10,433 |
| Skandinaviska Enskilda Banken AB (publ) | 213,891 | $9,957 |
| TD Asset Management Inc | 190,478 | $8,867 |
| SEGALL BRYANT & HAMILL, LLC | 189,477 | $8,820 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 187,433 | $8,882 |
| BARCLAYS PLC | 185,677 | $8,643 |
| NEUBERGER BERMAN GROUP LLC | 182,188 | $8,481 |
| Swiss National Bank | 176,500 | $8,216 |
| RICE HALL JAMES & ASSOCIATES, LLC | 171,830 | $7,999 |
| Invesco Ltd. | 158,089 | $7,359 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 148,489 | $7,002 |
| NEW YORK STATE COMMON RETIREMENT FUND | 146,123 | $6,802 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 144,239 | $6,714 |
| WELLS FARGO & COMPANY/MN | 139,461 | $6,492 |
| VICTORY CAPITAL MANAGEMENT INC | 138,685 | $6,456 |
| ENVESTNET ASSET MANAGEMENT INC | 130,363 | $6,068 |
| Sio Capital Management, LLC | 124,841 | $5,811 |
| Russell Investments Group, Ltd. | 119,905 | $5,582 |
| RHUMBLINE ADVISERS | 115,752 | $5,388 |
| SECTOR GAMMA AS | 115,000 | $5,353 |
| Moody Aldrich Partners LLC | 110,415 | $5,140 |
| Connor, Clark & Lunn Investment Management Ltd. | 100,567 | $4,681 |
| AWM Investment Company, Inc. | 100,000 | $4,655 |
| ALLIANCEBERNSTEIN L.P. | 93,020 | $4,330 |
| Decheng Capital LLC | 92,700 | $4,315 |
| Legal & General Group Plc | 87,802 | $4,087 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 85,568 | $3,983 |
| ALPS ADVISORS INC | 77,765 | $3,620 |
| Affinity Asset Advisors, LLC | 75,000 | $3,491 |
| SEI INVESTMENTS CO | 72,045 | $3,354 |
| CASTLEARK MANAGEMENT LLC | 62,790 | $2,923 |
| Man Group plc | 62,560 | $2,912 |
| STATE OF WISCONSIN INVESTMENT BOARD | 55,561 | $2,586 |
| Phocas Financial Corp. | 53,877 | $2,508 |
| MetLife Investment Management, LLC | 49,818 | $2,319 |
| TWO SIGMA INVESTMENTS, LP | 49,699 | $2,313 |
| Creative Planning | 47,321 | $2,203 |
| ROYAL BANK OF CANADA | 47,295 | $2,202 |
| Vestmark Advisory Solutions, Inc. | 46,552 | $2,167 |
| Lisanti Capital Growth, LLC | 43,040 | $2,004 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,002 | $1,955 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,511 | $1,560 |
| RAYMOND JAMES FINANCIAL INC | 33,354 | $1,553 |
| FIRST TRUST ADVISORS LP | 33,150 | $1,543 |
| State of New Jersey Common Pension Fund D | 30,537 | $1,421 |
| Brinker Capital Investments, LLC | 30,495 | $1,420 |
| INTECH INVESTMENT MANAGEMENT LLC | 30,243 | $1,408 |
| Handelsbanken Fonder AB | 29,500 | $1 |
| 139 other institutions | 1,011,670 | $40,128 |