CYTOKINETICS INC

Ticker: CYTK CUSIP: 23282W605 Class: EQTY

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 91,717 Value ($000) $5,828 Avg Close $62.21 Range $53.61 - $70.98

Q3 2025

Shares 161,517 Value ($000) $8,877 Avg Close $41.20 Range $32.66 - $55.92

Q2 2025

Shares 326,718 Value ($000) $10,795 Avg Close $34.78 Range $29.31 - $43.69

Q1 2025

Shares 144,961 Value ($000) $5,826 Avg Close $45.96 Range $39.81 - $52.80

Q4 2024

Shares 153,021 Value ($000) $7,198 Avg Close $51.94 Range $45.66 - $59.39

Q3 2024

Shares 225,021 Value ($000) $11,881 Avg Close $55.74 Range $51.05 - $61.38

Q2 2024

Shares 384,924 Value ($000) $20,855 Avg Close $60.36 Range $46.25 - $75.71

Q1 2024

Shares 281,671 Value ($000) $19,748 Avg Close $77.34 Range $61.33 - $110.25

Q4 2023

Shares 223,820 Value ($000) $18,687 Avg Close $36.21 Range $25.98 - $87.58

Q3 2023

Shares 233,933 Value ($000) $6,892 Avg Close $33.30 Range $28.96 - $37.10

Q4 2019

Shares 268,747 Value ($000) $2,851 Avg Close $10.27 Range $7.73 - $12.35

Q4 2017

Shares 210,000 Value ($000) $1,712 Avg Close $11.35 Range $7.00 - $15.95

Q3 2017

Shares 227,990 Value ($000) $3,306 Avg Close $13.66 Range $11.78 - $15.33

Q2 2017

Shares 217,990 Value ($000) $2,638 Avg Close $13.90 Range $11.00 - $17.20

Q1 2017

Shares 152,200 Value ($000) $1,956 Avg Close $11.69 Range $9.80 - $13.70

Q2 2016

Shares 32,069 Value ($000) $304 Avg Close $8.21 Range $6.92 - $10.13

Q1 2016

Shares 341,944 Value ($000) $2,411 Avg Close $7.31 Range $6.00 - $10.71

Q3 2015

Shares 372,250 Value ($000) $2,490 Avg Close $6.83 Range $5.88 - $7.95

Q2 2015

Shares 422,250 Value ($000) $2,838 Avg Close $6.56 Range $5.50 - $7.59

Q4 2014

Shares 493,212 Value ($000) $3,951 Avg Close $4.29 Range $3.05 - $8.25

Q3 2014

Shares 363,212 Value ($000) $1,279 Avg Close $4.20 Range $3.49 - $4.99

Q2 2014

Shares 65,100 Value ($000) $311 Avg Close $6.10 Range $3.96 - $13.26

Q1 2014

Shares 130,000 Value ($000) $1,235 Avg Close $9.04 Range $6.42 - $11.13

Q4 2013

Shares 167,000 Value ($000) $1,086 Avg Close $6.57 Range $5.99 - $7.72

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	91,717	$5,828	$62.21	$53.61 - $70.98
Q3 2025	161,517	$8,877	$41.20	$32.66 - $55.92
Q2 2025	326,718	$10,795	$34.78	$29.31 - $43.69
Q1 2025	144,961	$5,826	$45.96	$39.81 - $52.80
Q4 2024	153,021	$7,198	$51.94	$45.66 - $59.39
Q3 2024	225,021	$11,881	$55.74	$51.05 - $61.38
Q2 2024	384,924	$20,855	$60.36	$46.25 - $75.71
Q1 2024	281,671	$19,748	$77.34	$61.33 - $110.25
Q4 2023	223,820	$18,687	$36.21	$25.98 - $87.58
Q3 2023	233,933	$6,892	$33.30	$28.96 - $37.10
Q4 2019	268,747	$2,851	$10.27	$7.73 - $12.35
Q4 2017	210,000	$1,712	$11.35	$7.00 - $15.95
Q3 2017	227,990	$3,306	$13.66	$11.78 - $15.33
Q2 2017	217,990	$2,638	$13.90	$11.00 - $17.20
Q1 2017	152,200	$1,956	$11.69	$9.80 - $13.70
Q2 2016	32,069	$304	$8.21	$6.92 - $10.13
Q1 2016	341,944	$2,411	$7.31	$6.00 - $10.71
Q3 2015	372,250	$2,490	$6.83	$5.88 - $7.95
Q2 2015	422,250	$2,838	$6.56	$5.50 - $7.59
Q4 2014	493,212	$3,951	$4.29	$3.05 - $8.25
Q3 2014	363,212	$1,279	$4.20	$3.49 - $4.99
Q2 2014	65,100	$311	$6.10	$3.96 - $13.26
Q1 2014	130,000	$1,235	$9.04	$6.42 - $11.13
Q4 2013	167,000	$1,086	$6.57	$5.99 - $7.72