DENALI THERAPEUTICS INC

Ticker: DNLI CUSIP: 24823R105 Class: Common Stock

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,396,513 Value ($000) $23,056 Avg Close $16.88 Range $13.75 - $20.61

Q3 2025

Shares 821,513 Value ($000) $11,928 Avg Close $14.37 Range $12.58 - $16.20

Q2 2025

Shares 821,513 Value ($000) $11,493 Avg Close $14.07 Range $10.57 - $16.97

Q1 2025

Shares 821,513 Value ($000) $11,168 Avg Close $19.16 Range $13.30 - $24.34

Q4 2024

Shares 834,028 Value ($000) $16,997 Avg Close $25.60 Range $19.93 - $33.33

Q3 2024

Shares 834,028 Value ($000) $24,295 Avg Close $24.79 Range $19.74 - $32.13

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,396,513	$23,056	$16.88	$13.75 - $20.61
Q3 2025	821,513	$11,928	$14.37	$12.58 - $16.20
Q2 2025	821,513	$11,493	$14.07	$10.57 - $16.97
Q1 2025	821,513	$11,168	$19.16	$13.30 - $24.34
Q4 2024	834,028	$16,997	$25.60	$19.93 - $33.33
Q3 2024	834,028	$24,295	$24.79	$19.74 - $32.13