DISC MEDICINE INC

Ticker: IRON CUSIP: 254604101 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 200,000 Value ($000) $15,882 Avg Close $84.50 Range $65.26 - $99.50

Q3 2025

Shares 193,773 Value ($000) $12,805 Avg Close $59.49 Range $51.01 - $68.43

Q2 2025

Shares 186,418 Value ($000) $9,873 Avg Close $46.97 Range $30.82 - $55.52

Q1 2025

Shares 85,000 Value ($000) $4,219 Avg Close $55.60 Range $48.05 - $65.02

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	200,000	$15,882	$84.50	$65.26 - $99.50
Q3 2025	193,773	$12,805	$59.49	$51.01 - $68.43
Q2 2025	186,418	$9,873	$46.97	$30.82 - $55.52
Q1 2025	85,000	$4,219	$55.60	$48.05 - $65.02