DYNE THERAPEUTICS INC

Ticker: DYN CUSIP: 26818M108 Class: Common Stock

Frazier Life Sciences Management, L.P.'s Holding History (CIK: 0001892134)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,153,082 Value ($000) $61,674 Avg Close $18.94 Range $12.33 - $25.00

Q3 2025

Shares 2,718,105 Value ($000) $34,384 Avg Close $11.41 Range $8.06 - $14.35

Q2 2025

Shares 1,505,984 Value ($000) $14,337 Avg Close $11.01 Range $6.36 - $15.23

Q1 2025

Shares 1,443,341 Value ($000) $15,097 Avg Close $14.30 Range $9.96 - $26.22

Q4 2023

Shares 1,184,840 Value ($000) $15,758 Avg Close $9.77 Range $6.40 - $13.88

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,153,082	$61,674	$18.94	$12.33 - $25.00
Q3 2025	2,718,105	$34,384	$11.41	$8.06 - $14.35
Q2 2025	1,505,984	$14,337	$11.01	$6.36 - $15.23
Q1 2025	1,443,341	$15,097	$14.30	$9.96 - $26.22
Q4 2023	1,184,840	$15,758	$9.77	$6.40 - $13.88