Frazier Life Sciences Management, L.P. Diversified Active

Location: Palo Alto, CA

CIK: 0001892134 · Show all filings

Period: Q1 2026 (← Previous) (Next →)

Filing Date: May 15, 2026

Total Value: $3.887B (100.0% shares, 0.0% debt)

Holdings (38)

MIRM MIRUM PHARMACEUTICALS INC 18.3%

Value $709M Shares 7,679,684 Est. Cost $32.60 Unrealized +196.2%

NAMS NEWAMSTERDAM PHARMA COMPANY 14.0%

Value $542M Shares 16,943,774 Est. Cost $13.41 Unrealized +151.6%

ERAS ERASCA INC 10.3%

Value $399M Shares 24,675,188 Est. Cost $2.81 Unrealized +257.2%

BBIO BRIDGEBIO PHARMA INC 6.6%

Value $256M Shares 3,448,139 Est. Cost $21.54 Unrealized +245.7%

ARQT ARCUTIS BIOTHERAPEUTICS INC 6.0%

Value $233M Shares 9,874,511 Est. Cost $16.74 Unrealized +60.4%

MBX MBX BIOSCIENCES INC 5.1%

Value $199M Shares 6,652,013 Est. Cost $21.92 Unrealized +68.0%

PHAT PHATHOM PHARMACEUTICALS INC 3.6%

Value $139M Shares 12,466,489 Est. Cost $12.14 Unrealized +12.8%

MAZE MAZE THERAPEUTICS INC 3.5%

Value $136M Shares 4,567,274 Est. Cost $11.88 Unrealized +270.6%

KRYS KRYSTAL BIOTECH INC 3.2%

Value $124M Shares 481,307 Est. Cost $64.17 Unrealized +324.5%

TRVI TREVI THERAPEUTICS INC 3.1%

Value $119M Shares 9,939,547 Est. Cost $2.91 Unrealized +275.8%

PVLA PALVELLA THERAPEUTICS INC NE 2.8%

Value $110M Shares 882,400 Est. Cost $29.86 Unrealized +206.0%

KALV KALVISTA PHARMACEUTICALS INC 2.6%

Value $99.87M Shares 4,961,108 Est. Cost $10.00 Unrealized +54.9%

IRON DISC MEDICINE INC 2.2%

Value $86.63M Shares 1,354,852 Est. Cost $38.49 Unrealized +92.4%

CYTK CYTOKINETICS INC 2.0%

Value $76.45M Shares 1,159,879 Est. Cost $43.44 Unrealized +48.3%

RVMD REVOLUTION MEDICINES INC 1.7%

Value $65.71M Shares 675,686 Est. Cost $25.35 Unrealized +306.4%

DYN DYNE THERAPEUTICS INC 1.5%

Value $57.17M Shares 3,153,082 Est. Cost $13.76 Unrealized +24.4%

SVRA SAVARA INC 1.4%

Value $53.08M Shares 9,720,852 Est. Cost $3.69 Unrealized +54.5%

TARS TARSUS PHARMACEUTICALS INC 1.3%

Value $51.11M Shares 728,644 Est. Cost $17.82 Unrealized +291.1%

VOR VOR BIOPHARMA INC 1.2%

Value $45.38M Shares 2,543,939 Est. Cost $18.62 Unrealized -24.9%

AGIO AGIOS PHARMACEUTICALS INC 1.1%

Value $42.49M Shares 1,256,080 Est. Cost $31.94 Unrealized -12.2%

BCRX BIOCRYST PHARMACEUTICALS INC 1.0%

Value $38.17M Shares 4,009,240 Est. Cost $7.00 Unrealized 0.0%

ZLAB ZAI LAB LTD 0.9%

Value $35.78M Shares 1,902,320 Est. Cost $32.50 Unrealized —

AURA AURA BIOSCIENCES INC 0.9%

Value $34.12M Shares 5,100,000 Est. Cost $5.85 Unrealized -7.0%

ACAD ACADIA PHARMACEUTICALS INC 0.8%

Value $32.01M Shares 1,438,198 Est. Cost $23.92 Unrealized +5.4%

ASND ASCENDIS PHARMA A/S 0.8%

Value $30.5M Shares 133,333 Est. Cost $149.31 Unrealized —

LXEO LEXEO THERAPEUTICS INC 0.7%

Value $25.4M Shares 4,424,725 Est. Cost $5.15 Unrealized +46.2%

ALKS ALKERMES PLC 0.6%

Value $24.77M Shares 700,647 Est. Cost $27.95 Unrealized +15.7%

ACRS ACLARIS THERAPEUTICS INC 0.5%

Value $18.47M Shares 4,925,374 Est. Cost $3.33 Unrealized 0.0%

GLUE MONTE ROSA THERAPEUTICS INC 0.4%

Value $16.45M Shares 1,000,000 Est. Cost $20.66 Unrealized 0.0%

IMCR IMMUNOCORE HLDGS PLC 0.4%

Value $14.62M Shares 484,782 Est. Cost $31.01 Unrealized —

MNKD MANNKIND CORP 0.4%

Value $14.46M Shares 5,900,000 Est. Cost $5.52 Unrealized +0.8%

VALN VALNEVA SE 0.4%

Value $14.32M Shares 2,291,666 Est. Cost $8.03 Unrealized —

EOLS EVOLUS INC 0.3%

Value $10.81M Shares 2,630,665 Est. Cost $10.05 Unrealized -51.3%

NAMSW NEWAMSTERDAM PHARMA COMPANY 0.3%

Value $10.03M Shares 500,333 Est. Cost $0.87 Unrealized —

ALLO ALLOGENE THERAPEUTICS INC 0.2%

Value $9.264M Shares 3,796,668 Est. Cost $3.58 Unrealized -51.5%

AUTL AUTOLUS THERAPEUTICS LTD 0.2%

Value $6.138M Shares 4,447,910 Est. Cost $4.59 Unrealized —

IBIO IBIO INC 0.1%

Value $3.712M Shares 1,953,467 Est. Cost $1.36 Unrealized +69.5%

XLO XILIO THERAPEUTICS INC 0.1%

Value $3.553M Shares 422,505 Est. Cost $8.41 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
MIRM	MIRUM PHARMACEUTICALS INC	7,679,684	$709M	18.3%	$32.60	+196.2%	COM	604749101
NAMS	NEWAMSTERDAM PHARMA COMPANY	16,943,774	$542M	14.0%	$13.41	+151.6%	ORDINARY SHARES	N62509109
ERAS	ERASCA INC	24,675,188	$399M	10.3%	$2.81	+257.2%	COM	29479A108
BBIO	BRIDGEBIO PHARMA INC	3,448,139	$256M	6.6%	$21.54	+245.7%	COM	10806X102
ARQT	ARCUTIS BIOTHERAPEUTICS INC	9,874,511	$233M	6.0%	$16.74	+60.4%	COM	03969K108
MBX	MBX BIOSCIENCES INC	6,652,013	$199M	5.1%	$21.92	+68.0%	COM	55287L101
PHAT	PHATHOM PHARMACEUTICALS INC	12,466,489	$139M	3.6%	$12.14	+12.8%	COM	71722W107
MAZE	MAZE THERAPEUTICS INC	4,567,274	$136M	3.5%	$11.88	+270.6%	COM	578784100
KRYS	KRYSTAL BIOTECH INC	481,307	$124M	3.2%	$64.17	+324.5%	COM	501147102
TRVI	TREVI THERAPEUTICS INC	9,939,547	$119M	3.1%	$2.91	+275.8%	COM	89532M101
PVLA	PALVELLA THERAPEUTICS INC NE	882,400	$110M	2.8%	$29.86	+206.0%	COM	697947109
KALV	KALVISTA PHARMACEUTICALS INC	4,961,108	$99.87M	2.6%	$10.00	+54.9%	COM	483497103
IRON	DISC MEDICINE INC	1,354,852	$86.63M	2.2%	$38.49	+92.4%	COM	254604101
CYTK	CYTOKINETICS INC	1,159,879	$76.45M	2.0%	$43.44	+48.3%	COM NEW	23282W605
RVMD	REVOLUTION MEDICINES INC	675,686	$65.71M	1.7%	$25.35	+306.4%	COM	76155X100
DYN	DYNE THERAPEUTICS INC	3,153,082	$57.17M	1.5%	$13.76	+24.4%	COM	26818M108
SVRA	SAVARA INC	9,720,852	$53.08M	1.4%	$3.69	+54.5%	COM	805111101
TARS	TARSUS PHARMACEUTICALS INC	728,644	$51.11M	1.3%	$17.82	+291.1%	COM	87650L103
VOR	VOR BIOPHARMA INC	2,543,939	$45.38M	1.2%	$18.62	-24.9%	COM NEW	929033207
AGIO	AGIOS PHARMACEUTICALS INC	1,256,080	$42.49M	1.1%	$31.94	-12.2%	COM	00847X104
BCRX	BIOCRYST PHARMACEUTICALS INC	4,009,240	$38.17M	1.0%	$7.00	0.0%	COM	09058V103
ZLAB	ZAI LAB LTD	1,902,320	$35.78M	0.9%	$32.50	—	ADR	98887Q104
AURA	AURA BIOSCIENCES INC	5,100,000	$34.12M	0.9%	$5.85	-7.0%	COM	05153U107
ACAD	ACADIA PHARMACEUTICALS INC	1,438,198	$32.01M	0.8%	$23.92	+5.4%	COM	004225108
ASND	ASCENDIS PHARMA A/S	133,333	$30.5M	0.8%	$149.31	—	SPONSORED ADR	04351P101
LXEO	LEXEO THERAPEUTICS INC	4,424,725	$25.4M	0.7%	$5.15	+46.2%	COM	52886X107
ALKS	ALKERMES PLC	700,647	$24.77M	0.6%	$27.95	+15.7%	SHS	G01767105
ACRS	ACLARIS THERAPEUTICS INC	4,925,374	$18.47M	0.5%	$3.33	0.0%	COM	00461U105
GLUE	MONTE ROSA THERAPEUTICS INC	1,000,000	$16.45M	0.4%	$20.66	0.0%	COM	61225M102
IMCR	IMMUNOCORE HLDGS PLC	484,782	$14.62M	0.4%	$31.01	—	ADS	45258D105
MNKD	MANNKIND CORP	5,900,000	$14.46M	0.4%	$5.52	+0.8%	COM NEW	56400P706
VALN	VALNEVA SE	2,291,666	$14.32M	0.4%	$8.03	—	SPONSORED ADS	92025Y103
EOLS	EVOLUS INC	2,630,665	$10.81M	0.3%	$10.05	-51.3%	COM	30052C107
NAMSW	NEWAMSTERDAM PHARMA COMPANY	500,333	$10.03M	0.3%	$0.87	—	*W EXP 99/99/999	N62509117
ALLO	ALLOGENE THERAPEUTICS INC	3,796,668	$9.264M	0.2%	$3.58	-51.5%	COM	019770106
AUTL	AUTOLUS THERAPEUTICS LTD	4,447,910	$6.138M	0.2%	$4.59	—	SPON ADS	05280R100
IBIO	IBIO INC	1,953,467	$3.712M	0.1%	$1.36	+69.5%	COM NEW	451033708
XLO	XILIO THERAPEUTICS INC	422,505	$3.553M	0.1%	$8.41	—	COM	98422T209