ELEDON PHARMACEUTICALS INC

Institution	Shares	Value ($000)
Stonepine Capital Management, LLC	893,100	$1,349
ADAR1 Capital Management, LLC	1,821,812	$2,751
KINGDON CAPITAL MANAGEMENT, L.L.C.	1,039,275	$1,569
AWM Investment Company, Inc.	1,100,000	$1,661
Caligan Partners LP	555,978	$840
Jefferies Financial Group Inc.	1,580,625	$2,387
BOOTHBAY FUND MANAGEMENT, LLC	151,569	$229
Brevan Howard Capital Management LP	195,757	$286
Focus Partners Wealth	317,443	$479
Graham Capital Management, L.P.	70,260	$106
TWO SIGMA SECURITIES, LLC	19,345	$29
Forum Private Client Group LLC	10,000	$15
BARCLAYS PLC	87,472	$132
AQR CAPITAL MANAGEMENT LLC	60,215	$91
MARSHALL WACE, LLP	29,547	$45
CANADA PENSION PLAN INVESTMENT BOARD	29,400	$44
MILLENNIUM MANAGEMENT LLC	23,788	$36
TIAA TRUST, NATIONAL ASSOCIATION	19,000	$29
Mariner, LLC	12,414	$19
RAYMOND JAMES FINANCIAL INC	10,600	$16

Increased Positions (28)

Blue Owl Capital Holdings LP

Value ($000) $2,914 (+14.8%) Shares 1,929,912 (+96.9%)

SPHERA FUNDS MANAGEMENT LTD.

Value ($000) $3,220 (-2.9%) Shares 2,132,131 (+66.5%)

CM Management, LLC

Value ($000) $982 (-36.8%) Shares 650,000 (+8.3%)

Catalio Capital Management, LP

Value ($000) $1,902 (-30.8%) Shares 1,259,820 (+18.7%)

Zimmer Partners, LP

Value ($000) $3,600 (-23.8%) Shares 2,384,228 (+30.6%)

Ensign Peak Advisors, Inc

Value ($000) $3,722 (+13.6%) Shares 2,464,919 (+94.9%)

XTX Topco Ltd

Value ($000) $188 (+463.8%) Shares 124,247 (+867.1%)

VANGUARD GROUP INC

Value ($000) $6,100 (-27.9%) Shares 4,039,686 (+23.6%)

UBS Group AG

Value ($000) $896 (+270.0%) Shares 593,131 (+534.7%)

Kera Capital Partners, Inc.

Value ($000) $87 (+31.1%) Shares 39,770 (+54.3%)

JANE STREET GROUP, LLC

Value ($000) $739 (+46.2%) Shares 489,376 (+150.7%)

Quadrature Capital Ltd

Value ($000) $160 (+127.6%) Shares 106,014 (+291.2%)

BlackRock, Inc.

Value ($000) $5,477 (-39.0%) Shares 3,627,208 (+4.7%)

GOLDMAN SACHS GROUP INC

Value ($000) $300 (+89.9%) Shares 198,712 (+225.7%)

STATE STREET CORP

Value ($000) $1,169 (-31.2%) Shares 773,885 (+18.1%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $2,147 (-39.5%) Shares 1,421,617 (+3.8%)

Rockefeller Capital Management L.P.

Value ($000) $108 (+14.0%) Shares 71,666 (+95.5%)

Tower Research Capital LLC (TRC)

Value ($000) $41 (+49.5%) Shares 27,351 (+156.4%)

WELLS FARGO & COMPANY/MN

Value ($000) $104 (-17.3%) Shares 68,906 (+41.9%)

BANK OF AMERICA CORP /DE/

Value ($000) $91 (-22.5%) Shares 60,098 (+32.9%)

Institution	Prev Shares	Curr Shares	Change
Blue Owl Capital Holdings LP	979,912	1,929,912	+950,000 (+96.9%)
SPHERA FUNDS MANAGEMENT LTD.	1,280,233	2,132,131	+851,898 (+66.5%)
CM Management, LLC	600,000	650,000	+50,000 (+8.3%)
Catalio Capital Management, LP	1,061,132	1,259,820	+198,688 (+18.7%)
Zimmer Partners, LP	1,825,000	2,384,228	+559,228 (+30.6%)
Ensign Peak Advisors, Inc	1,264,919	2,464,919	+1,200,000 (+94.9%)
XTX Topco Ltd	12,848	124,247	+111,399 (+867.1%)
VANGUARD GROUP INC	3,267,783	4,039,686	+771,903 (+23.6%)
UBS Group AG	93,453	593,131	+499,678 (+534.7%)
Kera Capital Partners, Inc.	25,770	39,770	+14,000 (+54.3%)
JANE STREET GROUP, LLC	195,201	489,376	+294,175 (+150.7%)
Quadrature Capital Ltd	27,100	106,014	+78,914 (+291.2%)
BlackRock, Inc.	3,465,082	3,627,208	+162,126 (+4.7%)
GOLDMAN SACHS GROUP INC	61,006	198,712	+137,706 (+225.7%)
STATE STREET CORP	655,476	773,885	+118,409 (+18.1%)
GEODE CAPITAL MANAGEMENT, LLC	1,368,940	1,421,617	+52,677 (+3.8%)
Rockefeller Capital Management L.P.	36,666	71,666	+35,000 (+95.5%)
Tower Research Capital LLC (TRC)	10,669	27,351	+16,682 (+156.4%)
WELLS FARGO & COMPANY/MN	48,552	68,906	+20,354 (+41.9%)
BANK OF AMERICA CORP /DE/	45,229	60,098	+14,869 (+32.9%)

Decreased Positions (16)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $267 (-70.5%) Shares 176,990 (-49.3%)

ROYAL BANK OF CANADA

Value ($000) $3 (-96.9%) Shares 1,592 (-95.8%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $175 (-49.9%) Shares 115,682 (-14.2%)

Bank of New York Mellon Corp

Value ($000) $201 (-46.9%) Shares 132,902 (-8.9%)

Police & Firemen's Retirement System of New Jersey

Value ($000) $18 (-67.5%) Shares 11,856 (-44.3%)

OSAIC HOLDINGS, INC.

Value ($000) $1 (-97.6%) Shares 405 (-96.0%)

RHUMBLINE ADVISERS

Value ($000) $67 (-51.4%) Shares 44,617 (-16.7%)

INTECH INVESTMENT MANAGEMENT LLC

Value ($000) $35 (-48.6%) Shares 22,850 (-11.8%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $40 (-45.6%) Shares 26,797 (-6.6%)

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

Value ($000) $40 (-43.4%) Shares 26,755 (-3.0%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $18 (-43.0%) Shares 11,883 (-2.2%)

JPMORGAN CHASE & CO

Value ($000) $34 (-42.3%) Shares 22,442 (-1.1%)

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

Value ($000) $5 (-45.0%) Shares 3,455 (-5.6%)

SBI Securities Co., Ltd.

Value ($000) $0 (-66.9%) Shares 63 (-43.2%)

PNC Financial Services Group, Inc.

Value ($000) $0 (-65.2%) Shares 5 (-44.4%)

AMALGAMATED BANK

Value ($000) $0 (-40.0%) Shares 1,765 (-11.8%)

Institution	Prev Shares	Curr Shares	Change
RENAISSANCE TECHNOLOGIES LLC	349,200	176,990	-172,210 (-49.3%)
ROYAL BANK OF CANADA	37,855	1,592	-36,263 (-95.8%)
DIMENSIONAL FUND ADVISORS LP	134,761	115,682	-19,079 (-14.2%)
Bank of New York Mellon Corp	145,872	132,902	-12,970 (-8.9%)
Police & Firemen's Retirement System of New Jersey	21,293	11,856	-9,437 (-44.3%)
OSAIC HOLDINGS, INC.	10,000	405	-9,595 (-96.0%)
RHUMBLINE ADVISERS	53,564	44,617	-8,947 (-16.7%)
INTECH INVESTMENT MANAGEMENT LLC	25,900	22,850	-3,050 (-11.8%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	28,700	26,797	-1,903 (-6.6%)
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	27,583	26,755	-828 (-3.0%)
BNP PARIBAS ARBITRAGE, SA	12,154	11,883	-271 (-2.2%)
JPMORGAN CHASE & CO	22,691	22,442	-249 (-1.1%)
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	3,660	3,455	-205 (-5.6%)
SBI Securities Co., Ltd.	111	63	-48 (-43.2%)
PNC Financial Services Group, Inc.	9	5	-4 (-44.4%)
AMALGAMATED BANK	2,002	1,765	-237 (-11.8%)

Exited Positions (19)

Velan Capital Investment Management LP

Value ($000) $899 Shares 346,973

Siren, L.L.C.

Value ($000) $5,368 Shares 2,072,767

RA CAPITAL MANAGEMENT, L.P.

Value ($000) $9,237 Shares 3,566,338

Nantahala Capital Management, LLC

Value ($000) $2,956 Shares 1,141,237

Kovitz Investment Group Partners, LLC

Value ($000) $1,898 Shares 732,975

Woodline Partners LP

Value ($000) $2,074 Shares 800,822

WELLINGTON MANAGEMENT GROUP LLP

Value ($000) $3,325 Shares 1,283,939

Catalyst Funds Management Pty Ltd

Value ($000) $30 Shares 11,400

BRIGHTON JONES LLC

Value ($000) $102 Shares 39,355

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $87 Shares 33,400

DEUTSCHE BANK AG\

Value ($000) $166 Shares 64,110

Squarepoint Ops LLC

Value ($000) $94 Shares 36,297

AMERICAN CENTURY COMPANIES INC

Value ($000) $56 Shares 21,572

PANAGORA ASSET MANAGEMENT INC

Value ($000) $48 Shares 18,628

MANUFACTURERS LIFE INSURANCE COMPANY, THE

Value ($000) $49 Shares 19,072

GROUP ONE TRADING, L.P.

Value ($000) $11 Shares 4,217

Redwood Park Advisors LLC

Value ($000) $2 Shares 700

SRS Capital Advisors, Inc.

Value ($000) $0 Shares 152

SIMPLEX TRADING, LLC

Value ($000) $0 Shares 15,997

Institution	Prev Shares	Prev Value ($000)
Velan Capital Investment Management LP	346,973	$899
Siren, L.L.C.	2,072,767	$5,368
RA CAPITAL MANAGEMENT, L.P.	3,566,338	$9,237
Nantahala Capital Management, LLC	1,141,237	$2,956
Kovitz Investment Group Partners, LLC	732,975	$1,898
Woodline Partners LP	800,822	$2,074
WELLINGTON MANAGEMENT GROUP LLP	1,283,939	$3,325
Catalyst Funds Management Pty Ltd	11,400	$30
BRIGHTON JONES LLC	39,355	$102
BRIDGEWAY CAPITAL MANAGEMENT, LLC	33,400	$87
DEUTSCHE BANK AG\	64,110	$166
Squarepoint Ops LLC	36,297	$94
AMERICAN CENTURY COMPANIES INC	21,572	$56
PANAGORA ASSET MANAGEMENT INC	18,628	$48
MANUFACTURERS LIFE INSURANCE COMPANY, THE	19,072	$49
GROUP ONE TRADING, L.P.	4,217	$11
Redwood Park Advisors LLC	700	$2
SRS Capital Advisors, Inc.	152	$0
SIMPLEX TRADING, LLC	15,997	$0