| BVF INC/IL | 6,293,282 | $9,503 |
| VANGUARD GROUP INC | 4,039,686 | $6,100 |
| BlackRock, Inc. | 3,627,208 | $5,477 |
| Defilade Capital Management, L.P. | 3,290,450 | $4,969 |
| Ensign Peak Advisors, Inc | 2,464,919 | $3,722 |
| Zimmer Partners, LP | 2,384,228 | $3,600 |
| SPHERA FUNDS MANAGEMENT LTD. | 2,132,131 | $3,220 |
| Blue Owl Capital Holdings LP | 1,929,912 | $2,914 |
| ADAR1 Capital Management, LLC | 1,821,812 | $2,751 |
| Jefferies Financial Group Inc. | 1,580,625 | $2,387 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,421,617 | $2,147 |
| Catalio Capital Management, LP | 1,259,820 | $1,902 |
| AWM Investment Company, Inc. | 1,100,000 | $1,661 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,039,275 | $1,569 |
| Stonepine Capital Management, LLC | 893,100 | $1,349 |
| Sanofi | 814,980 | $1,231 |
| STATE STREET CORP | 773,885 | $1,169 |
| CM Management, LLC | 650,000 | $982 |
| 22NW, LP | 636,364 | $961 |
| SG Americas Securities, LLC | 627,392 | $1 |
| UBS Group AG | 593,131 | $896 |
| Caligan Partners LP | 555,978 | $840 |
| JANE STREET GROUP, LLC | 489,376 | $739 |
| NORTHERN TRUST CORP | 429,813 | $649 |
| Focus Partners Wealth | 317,443 | $479 |
| MORGAN STANLEY | 240,545 | $363 |
| GOLDMAN SACHS GROUP INC | 198,712 | $300 |
| Brevan Howard Capital Management LP | 195,757 | $286 |
| RENAISSANCE TECHNOLOGIES LLC | 176,990 | $267 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 173,131 | $261 |
| BOOTHBAY FUND MANAGEMENT, LLC | 151,569 | $229 |
| Bank of New York Mellon Corp | 132,902 | $201 |
| XTX Topco Ltd | 124,247 | $188 |
| DIMENSIONAL FUND ADVISORS LP | 115,682 | $175 |
| Quadrature Capital Ltd | 106,014 | $160 |
| BARCLAYS PLC | 87,472 | $132 |
| Nuveen, LLC | 76,292 | $115 |
| Rockefeller Capital Management L.P. | 71,666 | $108 |
| Graham Capital Management, L.P. | 70,260 | $106 |
| Daytona Street Capital LLC | 70,166 | $106 |
| WELLS FARGO & COMPANY/MN | 68,906 | $104 |
| AQR CAPITAL MANAGEMENT LLC | 60,215 | $91 |
| BANK OF AMERICA CORP /DE/ | 60,098 | $91 |
| INGALLS & SNYDER LLC | 51,849 | $0 |
| RHUMBLINE ADVISERS | 44,617 | $67 |
| Kera Capital Partners, Inc. | 39,770 | $87 |
| Invesco Ltd. | 31,669 | $48 |
| MARCO INVESTMENT MANAGEMENT LLC | 30,344 | $46 |
| HOWARD FINANCIAL SERVICES, LTD. | 30,000 | $45 |
| MARSHALL WACE, LLP | 29,547 | $45 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,499 | $0 |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,400 | $44 |
| Tower Research Capital LLC (TRC) | 27,351 | $41 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,797 | $40 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,755 | $40 |
| Cetera Investment Advisers | 26,584 | $40 |
| Virtu Financial LLC | 25,920 | $0 |
| MILLENNIUM MANAGEMENT LLC | 23,788 | $36 |
| INTECH INVESTMENT MANAGEMENT LLC | 22,850 | $35 |
| JPMORGAN CHASE & CO | 22,442 | $34 |
| TWO SIGMA SECURITIES, LLC | 19,345 | $29 |
| TIAA TRUST, NATIONAL ASSOCIATION | 19,000 | $29 |
| MERCER GLOBAL ADVISORS INC /ADV | 17,684 | $27 |
| LPL Financial LLC | 17,460 | $26 |
| Mariner, LLC | 12,414 | $19 |
| BNP PARIBAS ARBITRAGE, SA | 11,883 | $18 |
| Police & Firemen's Retirement System of New Jersey | 11,856 | $18 |
| Summit Financial, LLC | 11,500 | $17 |
| Voya Investment Management LLC | 11,420 | $17 |
| Russell Investments Group, Ltd. | 10,781 | $16 |
| RAYMOND JAMES FINANCIAL INC | 10,600 | $16 |
| ProShare Advisors LLC | 10,266 | $16 |
| Forum Private Client Group LLC | 10,000 | $15 |
| Split Rock Private Trading & Wealth Management, LLC | 10,000 | $15 |
| Seven Fleet Capital Management LP | 6,000 | $9 |
| Ameritas Investment Partners, Inc. | 5,984 | $9 |
| Legal & General Group Plc | 5,333 | $8 |
| FMR LLC | 4,686 | $7 |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | $6 |
| Sterling Capital Management LLC | 3,659 | $6 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,455 | $5 |
| CWM, LLC | 2,011 | $0 |
| AMALGAMATED BANK | 1,765 | $0 |
| ROYAL BANK OF CANADA | 1,592 | $3 |
| Addison Advisors LLC | 1,300 | $2 |
| CITIGROUP INC | 1,279 | $2 |
| Clearstead Advisors, LLC | 500 | $1 |
| OSAIC HOLDINGS, INC. | 405 | $1 |
| EverSource Wealth Advisors, LLC | 349 | $1 |
| SBI Securities Co., Ltd. | 63 | $0 |
| ROTHSCHILD INVESTMENT LLC | 24 | $0 |
| PNC Financial Services Group, Inc. | 5 | $0 |
| Byrne Asset Management LLC | 1 | $0 |