| RA CAPITAL MANAGEMENT, L.P. | 11,293,828 | $77,711 |
| MPM BioImpact LLC | 2,671,480 | $10,686 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,923,639 | $8 |
| ADAR1 Capital Management, LLC | 1,432,475 | $5,730 |
| VANGUARD GROUP INC | 1,340,504 | $5,362 |
| Affinity Asset Advisors, LLC | 1,300,000 | $5,200 |
| Kynam Capital Management, LP | 1,028,341 | $4,113 |
| GREAT POINT PARTNERS LLC | 979,534 | $3,918 |
| SPHERA FUNDS MANAGEMENT LTD. | 932,247 | $3,729 |
| Point72 Asset Management, L.P. | 716,680 | $2,867 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 600,946 | $2,404 |
| TWO SIGMA INVESTMENTS, LP | 566,712 | $2,267 |
| Peapod Lane Capital LLC | 565,992 | $2,264 |
| NAN FUNG TRINITY (HK) LTD | 463,654 | $1,855 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 445,342 | $1,781 |
| KOTLER KEVIN | 400,000 | $1,600 |
| BlackRock, Inc. | 389,309 | $1,557 |
| RENAISSANCE TECHNOLOGIES LLC | 320,600 | $1,282 |
| GEODE CAPITAL MANAGEMENT, LLC | 310,756 | $1,244 |
| MARSHALL WACE, LLP | 304,015 | $1,216 |
| MILLENNIUM MANAGEMENT LLC | 296,314 | $1,185 |
| TD Asset Management Inc | 246,200 | $985 |
| CITADEL ADVISORS LLC | 239,043 | $956 |
| GOLDMAN SACHS GROUP INC | 224,883 | $900 |
| 683 Capital Management, LLC | 201,652 | $807 |
| JANE STREET GROUP, LLC | 187,403 | $750 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 159,300 | $637 |
| MORGAN STANLEY | 148,538 | $594 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 140,617 | $567 |
| AMERIPRISE FINANCIAL INC | 139,529 | $558 |
| STATE STREET CORP | 128,900 | $516 |
| TWO SIGMA ADVISERS, LP | 124,700 | $499 |
| NORTHERN TRUST CORP | 124,670 | $499 |
| ArchPoint Investors | 121,400 | $486 |
| Squadron Capital Management LLC | 100,000 | $400 |
| OMERS ADMINISTRATION Corp | 85,466 | $342 |
| Seven Fleet Capital Management LP | 76,400 | $306 |
| UBS Group AG | 71,323 | $285 |
| LPL Financial LLC | 62,000 | $248 |
| BARCLAYS PLC | 61,853 | $247 |
| Hudson Bay Capital Management LP | 48,736 | $195 |
| XTX Topco Ltd | 34,852 | $139 |
| Qube Research & Technologies Ltd | 34,596 | $138 |
| CITIZENS FINANCIAL GROUP INC/RI | 28,168 | $113 |
| HSBC HOLDINGS PLC | 24,744 | $99 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,918 | $80 |
| BALYASNY ASSET MANAGEMENT L.P. | 14,236 | $57 |
| Vanguard Personalized Indexing Management, LLC | 11,127 | $45 |
| BLAIR WILLIAM & CO/IL | 11,000 | $44 |
| Chicago Partners Investment Group LLC | 10,962 | $55 |
| Virtu Financial LLC | 10,655 | $0 |
| Scientech Research LLC | 10,428 | $42 |
| CITIGROUP INC | 10,331 | $41 |
| Persistent Asset Partners Ltd | 9,228 | $37 |
| FMR LLC | 6,349 | $25 |
| BANK OF AMERICA CORP /DE/ | 5,063 | $20 |
| Tower Research Capital LLC (TRC) | 3,357 | $13 |
| HARBOUR INVESTMENTS, INC. | 2,000 | $8 |
| OSAIC HOLDINGS, INC. | 600 | $2 |
| NISA INVESTMENT ADVISORS, LLC | 573 | $2 |
| BNP PARIBAS ARBITRAGE, SA | 513 | $2 |
| ROYAL BANK OF CANADA | 408 | $1 |
| JPMORGAN CHASE & CO | 46 | $0 |
| CWM, LLC | 29 | $0 |
| DEUTSCHE BANK AG\ | 1 | $0 |