| FCPM III SERVICES B.V. | 9,632,561 | $86,982 |
| PERCEPTIVE ADVISORS LLC | 5,869,076 | $52,998 |
| VR Adviser, LLC | 4,771,414 | $43,086 |
| Deep Track Capital, LP | 4,377,572 | $39,529 |
| Cormorant Asset Management, LP | 4,000,000 | $36,120 |
| Blue Owl Capital Holdings LP | 3,360,937 | $30,349 |
| Siren, L.L.C. | 3,336,264 | $30,126 |
| BRAIDWELL LP | 3,131,319 | $28,276 |
| Nextech Invest, Ltd. | 2,124,943 | $19,188 |
| JANUS HENDERSON GROUP PLC | 1,900,000 | $17,110 |
| MPM BioImpact LLC | 1,840,898 | $16,623 |
| MILLENNIUM MANAGEMENT LLC | 1,499,520 | $13,541 |
| Kynam Capital Management, LP | 1,492,898 | $13,481 |
| FRANKLIN RESOURCES INC | 1,388,000 | $12,534 |
| Polar Capital Holdings Plc | 1,142,982 | $10,321 |
| Vestal Point Capital, LP | 1,055,000 | $9,527 |
| EVENTIDE ASSET MANAGEMENT, LLC | 950,000 | $8,579 |
| Omega Fund Management, LLC | 876,357 | $7,914 |
| SR ONE CAPITAL MANAGEMENT, LP | 747,750 | $6,752 |
| MORGAN STANLEY | 718,485 | $6,488 |
| Affinity Asset Advisors, LLC | 643,370 | $5,810 |
| Point72 Asset Management, L.P. | 561,797 | $5,073 |
| Eversept Partners, LP | 455,835 | $4,116 |
| Privium Fund Management B.V. | 352,087 | $3,179 |
| MARSHALL WACE, LLP | 343,928 | $3,106 |
| ADAR1 Capital Management, LLC | 303,686 | $2,742 |
| Monashee Investment Management LLC | 295,000 | $2,664 |
| Woodline Partners LP | 250,000 | $2,258 |
| Elmind Capital, LP | 210,000 | $1,896 |
| DAFNA Capital Management LLC | 163,645 | $1,478 |
| TWO SIGMA INVESTMENTS, LP | 161,512 | $1,458 |
| GOLDMAN SACHS GROUP INC | 147,889 | $1,335 |
| KENNEDY CAPITAL MANAGEMENT LLC | 76,765 | $693 |
| HRT FINANCIAL LP | 64,380 | $1 |
| JANE STREET GROUP, LLC | 56,454 | $510 |
| Quadrature Capital Ltd | 48,583 | $439 |
| BNP PARIBAS ARBITRAGE, SA | 35,877 | $324 |
| Virtus Investment Advisers, LLC | 31,445 | $284 |
| NORTHERN TRUST CORP | 30,085 | $272 |
| GEODE CAPITAL MANAGEMENT, LLC | 29,018 | $262 |
| CITADEL ADVISORS LLC | 25,383 | $229 |
| Pale Fire Capital SE | 24,004 | $217 |
| AMERICAN CENTURY COMPANIES INC | 23,980 | $217 |
| XTX Topco Ltd | 23,922 | $216 |
| RENAISSANCE TECHNOLOGIES LLC | 20,782 | $188 |
| RAYMOND JAMES FINANCIAL INC | 19,960 | $180 |
| TWO SIGMA ADVISERS, LP | 17,300 | $156 |
| Schonfeld Strategic Advisors LLC | 16,645 | $150 |
| Jump Financial, LLC | 13,400 | $121 |
| WELLS FARGO & COMPANY/MN | 11,217 | $101 |
| PFS Partners, LLC | 11,000 | $99 |
| ROYAL BANK OF CANADA | 7,915 | $71 |
| JPMORGAN CHASE & CO | 2,614 | $24 |
| CITIGROUP INC | 1,688 | $15 |
| UBS Group AG | 1,597 | $14 |
| MAI Capital Management | 776 | $7 |
| SBI Securities Co., Ltd. | 28 | $0 |