ENGENE HOLDINGS INC

Ticker: ENGN CUSIP: 29286M105 Class: COM

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (25)

Nextech Invest, Ltd.
Value ($000) $19,188 Shares 2,124,943
Monashee Investment Management LLC
Value ($000) $2,664 Shares 295,000
Siren, L.L.C.
Value ($000) $30,126 Shares 3,336,264
Privium Fund Management B.V.
Value ($000) $3,179 Shares 352,087
DAFNA Capital Management LLC
Value ($000) $1,478 Shares 163,645
Eversept Partners, LP
Value ($000) $4,116 Shares 455,835
ADAR1 Capital Management, LLC
Value ($000) $2,742 Shares 303,686
EVENTIDE ASSET MANAGEMENT, LLC
Value ($000) $8,579 Shares 950,000
Virtus Investment Advisers, LLC
Value ($000) $284 Shares 31,445
Polar Capital Holdings Plc
Value ($000) $10,321 Shares 1,142,982
JANUS HENDERSON GROUP PLC
Value ($000) $17,110 Shares 1,900,000
KENNEDY CAPITAL MANAGEMENT LLC
Value ($000) $693 Shares 76,765
Woodline Partners LP
Value ($000) $2,258 Shares 250,000
XTX Topco Ltd
Value ($000) $216 Shares 23,922
Quadrature Capital Ltd
Value ($000) $439 Shares 48,583
TWO SIGMA INVESTMENTS, LP
Value ($000) $1,458 Shares 161,512
JANE STREET GROUP, LLC
Value ($000) $510 Shares 56,454
BNP PARIBAS ARBITRAGE, SA
Value ($000) $324 Shares 35,877
Jump Financial, LLC
Value ($000) $121 Shares 13,400
AMERICAN CENTURY COMPANIES INC
Value ($000) $217 Shares 23,980

Increased Positions (16)

Omega Fund Management, LLC
Value ($000) $7,914 (+120.1%) Shares 876,357 (+66.5%)
Blue Owl Capital Holdings LP
Value ($000) $30,349 (+35.6%) Shares 3,360,937 (+2.5%)
MPM BioImpact LLC
Value ($000) $16,623 (+359.0%) Shares 1,840,898 (+247.1%)
Cormorant Asset Management, LP
Value ($000) $36,120 (+127.6%) Shares 4,000,000 (+72.1%)
PERCEPTIVE ADVISORS LLC
Value ($000) $52,998 (+270.0%) Shares 5,869,076 (+179.8%)
Deep Track Capital, LP
Value ($000) $39,529 (+158.5%) Shares 4,377,572 (+95.5%)
BRAIDWELL LP
Value ($000) $28,276 (+82.7%) Shares 3,131,319 (+38.2%)
Affinity Asset Advisors, LLC
Value ($000) $5,810 (+1004.7%) Shares 643,370 (+735.5%)
Vestal Point Capital, LP
Value ($000) $9,527 (+277.0%) Shares 1,055,000 (+185.1%)
MILLENNIUM MANAGEMENT LLC
Value ($000) $13,541 (+9569.9%) Shares 1,499,520 (+7214.0%)
FRANKLIN RESOURCES INC
Value ($000) $12,534 (+76.8%) Shares 1,388,000 (+33.7%)
MORGAN STANLEY
Value ($000) $6,488 (+118.2%) Shares 718,485 (+65.1%)
PFS Partners, LLC
Value ($000) $99 (+61.6%) Shares 11,000 (+22.2%)
Pale Fire Capital SE
Value ($000) $217 (+83.9%) Shares 24,004 (+39.1%)
RAYMOND JAMES FINANCIAL INC
Value ($000) $180 (+163.9%) Shares 19,960 (+99.6%)
CITIGROUP INC
Value ($000) $15 (+217657.1%) Shares 1,688 (+168700.0%)

Decreased Positions (7)

Kynam Capital Management, LP
Value ($000) $13,481 (-60.5%) Shares 1,492,898 (-70.1%)
VR Adviser, LLC
Value ($000) $43,086 (+25.0%) Shares 4,771,414 (-5.4%)
Point72 Asset Management, L.P.
Value ($000) $5,073 (-38.5%) Shares 561,797 (-53.5%)
CITADEL ADVISORS LLC
Value ($000) $229 (-42.5%) Shares 25,383 (-56.5%)
Schonfeld Strategic Advisors LLC
Value ($000) $150 (-12.2%) Shares 16,645 (-33.6%)
WELLS FARGO & COMPANY/MN
Value ($000) $101 (-17.2%) Shares 11,217 (-37.4%)
SBI Securities Co., Ltd.
Value ($000) $0 (+19.3%) Shares 28 (-9.7%)

Exited Positions (6)

SPHERA FUNDS MANAGEMENT LTD.
Value ($000) $3,445 Shares 504,409
Frazier Life Sciences Management, L.P.
Value ($000) $7,905 Shares 1,157,380
ADAGE CAPITAL PARTNERS GP, L.L.C.
Value ($000) $6,830 Shares 1,000,000
BANK OF AMERICA CORP /DE/
Value ($000) $4,420 Shares 647,192
Hudson Bay Capital Management LP
Value ($000) $76 Shares 11,074
TORONTO DOMINION BANK
Value ($000) $68 Shares 10,000