| BAKER BROS. ADVISORS LP | 5,072,730 | $52,148 |
| 5AM Venture Management, LLC | 4,056,379 | $41,700 |
| BlackRock, Inc. | 2,147,260 | $22,074 |
| TCG Crossover Management, LLC | 2,088,392 | $21,469 |
| VANGUARD GROUP INC | 1,632,460 | $16,782 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,044,758 | $10,740 |
| StepStone Group LP | 761,277 | $7,826 |
| GEODE CAPITAL MANAGEMENT, LLC | 639,947 | $6,580 |
| STATE STREET CORP | 508,789 | $5,230 |
| MILLENNIUM MANAGEMENT LLC | 497,695 | $5,116 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 362,786 | $3,729 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 327,423 | $3 |
| ACADIAN ASSET MANAGEMENT LLC | 310,833 | $3 |
| CITADEL ADVISORS LLC | 292,770 | $3,010 |
| DIMENSIONAL FUND ADVISORS LP | 273,378 | $2,810 |
| MORGAN STANLEY | 260,251 | $2,675 |
| RENAISSANCE TECHNOLOGIES LLC | 252,635 | $2,597 |
| ROYCE & ASSOCIATES LP | 247,147 | $2,541 |
| NORTHERN TRUST CORP | 226,301 | $2,326 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 221,269 | $2,275 |
| GOLDMAN SACHS GROUP INC | 205,173 | $2,109 |
| BNP PARIBAS ARBITRAGE, SA | 180,969 | $1,860 |
| Qube Research & Technologies Ltd | 176,018 | $1,809 |
| Woodline Partners LP | 142,110 | $1,461 |
| ALGERT GLOBAL LLC | 128,611 | $1 |
| Trexquant Investment LP | 121,280 | $1,247 |
| XTX Topco Ltd | 117,668 | $1,210 |
| SPHERA FUNDS MANAGEMENT LTD. | 110,942 | $1,140 |
| MOORE CAPITAL MANAGEMENT, LP | 105,000 | $1,079 |
| JANE STREET GROUP, LLC | 85,662 | $881 |
| AMERIPRISE FINANCIAL INC | 84,893 | $873 |
| Bank of New York Mellon Corp | 79,375 | $816 |
| AMERICAN CENTURY COMPANIES INC | 75,282 | $774 |
| JPMORGAN CHASE & CO | 70,761 | $727 |
| Quantinno Capital Management LP | 67,717 | $696 |
| BARCLAYS PLC | 67,147 | $690 |
| D. E. Shaw & Co., Inc. | 66,878 | $688 |
| BANK OF AMERICA CORP /DE/ | 65,979 | $678 |
| CANTOR FITZGERALD, L. P. | 57,000 | $586 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,545 | $572 |
| Nuveen, LLC | 56,416 | $580 |
| Lynx1 Capital Management LP | 51,689 | $531 |
| TWO SIGMA INVESTMENTS, LP | 49,302 | $507 |
| Nan Fung Group Holdings Ltd | 49,082 | $505 |
| Brevan Howard Capital Management LP | 47,967 | $493 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 45,952 | $317 |
| GREAT LAKES ADVISORS, LLC | 43,268 | $445 |
| Invesco Ltd. | 41,033 | $422 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 40,000 | $411 |
| TD Asset Management Inc | 37,788 | $388 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 37,502 | $386 |
| ExodusPoint Capital Management, LP | 37,430 | $385 |
| MARTINGALE ASSET MANAGEMENT L P | 37,053 | $381 |
| RHUMBLINE ADVISERS | 36,223 | $372 |
| WELLS FARGO & COMPANY/MN | 32,163 | $331 |
| AQR CAPITAL MANAGEMENT LLC | 26,254 | $270 |
| CANADA PENSION PLAN INVESTMENT BOARD | 25,600 | $263 |
| Dynamic Technology Lab Private Ltd | 25,302 | $260 |
| ALLIANCEBERNSTEIN L.P. | 24,320 | $250 |
| Creative Planning | 22,082 | $227 |
| Point72 Asset Management, L.P. | 21,871 | $225 |
| HSBC HOLDINGS PLC | 20,833 | $216 |
| DEUTSCHE BANK AG\ | 20,821 | $214 |
| MARSHALL WACE, LLP | 20,657 | $212 |
| Quadrature Capital Ltd | 20,318 | $209 |
| UBS Group AG | 19,036 | $196 |
| MetLife Investment Management, LLC | 17,802 | $183 |
| Allspring Global Investments Holdings, LLC | 17,495 | $176 |
| FMR LLC | 16,822 | $173 |
| AlphaQuest LLC | 15,629 | $161 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,361 | $158 |
| BALYASNY ASSET MANAGEMENT L.P. | 14,017 | $144 |
| Walleye Capital LLC | 13,534 | $139 |
| Magnetar Financial LLC | 13,373 | $137 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,248 | $136 |
| INTECH INVESTMENT MANAGEMENT LLC | 11,929 | $123 |
| Inscription Capital, LLC | 11,835 | $122 |
| Russell Investments Group, Ltd. | 11,571 | $119 |
| IHT Wealth Management, LLC | 11,100 | $114 |
| AXQ CAPITAL, LP | 10,650 | $109 |
| Police & Firemen's Retirement System of New Jersey | 9,471 | $97 |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,877 | $91 |
| China Universal Asset Management Co., Ltd. | 6,228 | $64 |
| CITIGROUP INC | 4,124 | $42 |
| Versant Capital Management, Inc | 4,046 | $42 |
| Legal & General Group Plc | 2,557 | $26 |
| Ameritas Investment Partners, Inc. | 2,417 | $25 |
| CWM, LLC | 2,114 | $0 |
| Tower Research Capital LLC (TRC) | 1,937 | $20 |
| Mirae Asset Global Investments Co., Ltd. | 1,857 | $19 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,753 | $18 |
| Sterling Capital Management LLC | 1,640 | $17 |
| PNC Financial Services Group, Inc. | 1,141 | $12 |
| ROYAL BANK OF CANADA | 987 | $11 |
| SRS Capital Advisors, Inc. | 918 | $9 |
| AMALGAMATED BANK | 894 | $0 |
| GF FUND MANAGEMENT CO. LTD. | 751 | $8 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 432 | $4 |
| EverSource Wealth Advisors, LLC | 376 | $4 |
| Optiver Holding B.V. | 346 | $4 |
| 12 other institutions | 1,381 | $12 |