| GILEAD SCIENCES, INC. | 16,707,477 | $550,616 |
| TANG CAPITAL MANAGEMENT LLC | 3,921,219 | $128,224 |
| Madison Avenue Partners, LP | 2,213,169 | $72,371 |
| EcoR1 Capital, LLC | 1,667,119 | $54,515 |
| AMERIPRISE FINANCIAL INC | 1,451,239 | $47,456 |
| Prosight Management, LP | 1,074,112 | $35,123 |
| Point72 Asset Management, L.P. | 486,209 | $15,899 |
| DME Capital Management, LP | 482,746 | $15,786 |
| SEGALL BRYANT & HAMILL, LLC | 448,096 | $14,653 |
| UBS Group AG | 349,444 | $11,427 |
| MILLENNIUM MANAGEMENT LLC | 339,354 | $11,097 |
| BlackRock, Inc. | 314,269 | $10,277 |
| RENAISSANCE TECHNOLOGIES LLC | 310,600 | $10,157 |
| D. E. Shaw & Co., Inc. | 274,999 | $8,992 |
| Hudson Bay Capital Management LP | 170,000 | $5,559 |
| DAFNA Capital Management LLC | 130,175 | $4,257 |
| NORGES BANK | 90,000 | $2,943 |
| KOTLER KEVIN | 90,000 | $2,943 |
| CITADEL ADVISORS LLC | 89,396 | $2,923 |
| MORGAN STANLEY | 68,285 | $2,233 |
| FMR LLC | 56,969 | $1,863 |
| ALPS ADVISORS INC | 53,791 | $1,759 |
| Man Group plc | 47,581 | $1,556 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 43,856 | $1,434 |
| Massar Capital Management, LP | 39,000 | $1,275 |
| BAROMETER CAPITAL MANAGEMENT INC. | 37,100 | $884 |
| Crossmark Global Holdings, Inc. | 32,977 | $1,078 |
| Monaco Asset Management SAM | 32,520 | $1,063 |
| Western Standard LLC | 32,000 | $1,046 |
| BANK OF AMERICA CORP /DE/ | 30,969 | $1,013 |
| Jump Financial, LLC | 29,000 | $948 |
| AMERICAN CENTURY COMPANIES INC | 26,729 | $874 |
| XTX Topco Ltd | 23,219 | $759 |
| MOODY NATIONAL BANK TRUST DIVISION | 20,849 | $682 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,305 | $631 |
| TWO SIGMA INVESTMENTS, LP | 16,360 | $535 |
| QRG CAPITAL MANAGEMENT, INC. | 16,170 | $529 |
| Quadrature Capital Ltd | 15,006 | $491 |
| Erste Asset Management GmbH | 14,000 | $464 |
| Aquatic Capital Management LLC | 13,712 | $448 |
| TWO SIGMA ADVISERS, LP | 11,300 | $370 |
| MARSHALL WACE, LLP | 11,200 | $366 |
| GOLDMAN SACHS GROUP INC | 11,144 | $364 |
| BNP PARIBAS ARBITRAGE, SA | 11,098 | $363 |
| COMMONWEALTH EQUITY SERVICES, LLC | 8,861 | $290 |
| GEODE CAPITAL MANAGEMENT, LLC | 7,851 | $257 |
| ACADIAN ASSET MANAGEMENT LLC | 7,541 | $0 |
| RHUMBLINE ADVISERS | 6,972 | $228 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,968 | $228 |
| Ascent Group, LLC | 6,237 | $204 |
| ROYAL BANK OF CANADA | 5,355 | $175 |
| QUADRANT CAPITAL GROUP LLC | 3,520 | $115 |
| China Universal Asset Management Co., Ltd. | 2,356 | $77 |
| BARCLAYS PLC | 2,355 | $77 |
| SRS Capital Advisors, Inc. | 2,335 | $76 |
| VAN ECK ASSOCIATES CORP | 1,968 | $0 |
| SIGNATUREFD, LLC | 1,641 | $54 |
| GAMMA Investing LLC | 1,250 | $41 |
| State of Wyoming | 1,227 | $40 |
| CACTI ASSET MANAGEMENT LLC | 1,000 | $33 |
| Mirae Asset Global Investments Co., Ltd. | 702 | $23 |
| Tower Research Capital LLC (TRC) | 548 | $18 |
| CITIGROUP INC | 404 | $13 |
| Smartleaf Asset Management LLC | 389 | $13 |
| OSAIC HOLDINGS, INC. | 370 | $12 |
| DV EQUITIES, LLC | 332 | $11 |
| Larson Financial Group LLC | 288 | $9 |
| GF FUND MANAGEMENT CO. LTD. | 282 | $9 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 281 | $9 |
| JPMORGAN CHASE & CO | 239 | $8 |
| US BANCORP \DE\ | 182 | $6 |
| Farther Finance Advisors, LLC | 145 | $5 |
| Allworth Financial LP | 139 | $5 |
| Parallel Advisors, LLC | 103 | $3 |
| SageView Advisory Group, LLC | 80 | $3 |
| SIMPLEX TRADING, LLC | 74 | $2 |
| MAI Capital Management | 52 | $2 |
| Daiwa Securities Group Inc. | 51 | $0 |
| Crewe Advisors LLC | 46 | $2 |
| BESSEMER GROUP INC | 41 | $0 |
| BRYN MAWR TRUST Co | 36 | $1 |
| EverSource Wealth Advisors, LLC | 32 | $1 |
| Manning & Napier Advisors LLC | 26 | $1 |
| TD PRIVATE CLIENT WEALTH LLC | 24 | $1 |
| PNC Financial Services Group, Inc. | 22 | $1 |
| ASSETMARK, INC | 22 | $1 |
| Signature Equity Partners, LLC | 22 | $1 |
| IMA Wealth, Inc. | 15 | $0 |
| NewEdge Advisors, LLC | 6 | $0 |
| HUNTINGTON NATIONAL BANK | 4 | $0 |
| Caitong International Asset Management Co., Ltd | 4 | $0 |