GALAPAGOS NV

Institution	Shares	Value ($000)
Western Standard LLC	32,000	$1,046
Massar Capital Management, LP	39,000	$1,275
SUSQUEHANNA INTERNATIONAL GROUP, LLP	6,968	$228
Smartleaf Asset Management LLC	389	$13
SageView Advisory Group, LLC	80	$3
BRYN MAWR TRUST Co	36	$1
Manning & Napier Advisors LLC	26	$1
IMA Wealth, Inc.	15	$0
ACADIAN ASSET MANAGEMENT LLC	7,541	$0
Caitong International Asset Management Co., Ltd	4	$0
HUNTINGTON NATIONAL BANK	4	$0
BESSEMER GROUP INC	41	$0

Increased Positions (25)

BAROMETER CAPITAL MANAGEMENT INC.

Value ($000) $884 (-7.6%) Shares 37,100 (+34.3%)

XTX Topco Ltd

Value ($000) $759 (+81.8%) Shares 23,219 (+92.6%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $11,097 (+109.5%) Shares 339,354 (+121.9%)

UBS Group AG

Value ($000) $11,427 (+115.6%) Shares 349,444 (+128.4%)

ALPS ADVISORS INC

Value ($000) $1,759 (+59.2%) Shares 53,791 (+68.6%)

Point72 Asset Management, L.P.

Value ($000) $15,899 (+3.4%) Shares 486,209 (+9.5%)

D. E. Shaw & Co., Inc.

Value ($000) $8,992 (+29.0%) Shares 274,999 (+36.7%)

CITADEL ADVISORS LLC

Value ($000) $2,923 (+428.5%) Shares 89,396 (+459.8%)

BlackRock, Inc.

Value ($000) $10,277 (+23.7%) Shares 314,269 (+31.0%)

AMERIPRISE FINANCIAL INC

Value ($000) $47,456 (-3.3%) Shares 1,451,239 (+2.4%)

Man Group plc

Value ($000) $1,556 (+24.1%) Shares 47,581 (+31.5%)

MORGAN STANLEY

Value ($000) $2,233 (+0.6%) Shares 68,285 (+6.6%)

SRS Capital Advisors, Inc.

Value ($000) $76 (+295.7%) Shares 2,335 (+319.2%)

RHUMBLINE ADVISERS

Value ($000) $228 (+82.8%) Shares 6,972 (+93.7%)

TWO SIGMA ADVISERS, LP

Value ($000) $370 (+22.6%) Shares 11,300 (+29.9%)

FMR LLC

Value ($000) $1,863 (-0.4%) Shares 56,969 (+5.5%)

BARCLAYS PLC

Value ($000) $77 (+2574.9%) Shares 2,355 (+2255.0%)

QRG CAPITAL MANAGEMENT, INC.

Value ($000) $529 (+1.1%) Shares 16,170 (+7.1%)

State of Wyoming

Value ($000) $40 (+21.2%) Shares 1,227 (+28.3%)

JPMORGAN CHASE & CO

Value ($000) $8 (+217.9%) Shares 239 (+236.6%)

Institution	Prev Shares	Curr Shares	Change
BAROMETER CAPITAL MANAGEMENT INC.	27,617	37,100	+9,483 (+34.3%)
XTX Topco Ltd	12,057	23,219	+11,162 (+92.6%)
MILLENNIUM MANAGEMENT LLC	152,902	339,354	+186,452 (+121.9%)
UBS Group AG	152,999	349,444	+196,445 (+128.4%)
ALPS ADVISORS INC	31,905	53,791	+21,886 (+68.6%)
Point72 Asset Management, L.P.	443,869	486,209	+42,340 (+9.5%)
D. E. Shaw & Co., Inc.	201,169	274,999	+73,830 (+36.7%)
CITADEL ADVISORS LLC	15,969	89,396	+73,427 (+459.8%)
BlackRock, Inc.	239,843	314,269	+74,426 (+31.0%)
AMERIPRISE FINANCIAL INC	1,416,934	1,451,239	+34,305 (+2.4%)
Man Group plc	36,197	47,581	+11,384 (+31.5%)
MORGAN STANLEY	64,063	68,285	+4,222 (+6.6%)
SRS Capital Advisors, Inc.	557	2,335	+1,778 (+319.2%)
RHUMBLINE ADVISERS	3,600	6,972	+3,372 (+93.7%)
TWO SIGMA ADVISERS, LP	8,700	11,300	+2,600 (+29.9%)
FMR LLC	54,011	56,969	+2,958 (+5.5%)
BARCLAYS PLC	100	2,355	+2,255 (+2255.0%)
QRG CAPITAL MANAGEMENT, INC.	15,093	16,170	+1,077 (+7.1%)
State of Wyoming	956	1,227	+271 (+28.3%)
JPMORGAN CHASE & CO	71	239	+168 (+236.6%)

Decreased Positions (32)

Prosight Management, LP

Value ($000) $35,123 (-11.8%) Shares 1,074,112 (-6.6%)

TANG CAPITAL MANAGEMENT LLC

Value ($000) $128,224 (-10.8%) Shares 3,921,219 (-5.5%)

SEGALL BRYANT & HAMILL, LLC

Value ($000) $14,653 (-13.2%) Shares 448,096 (-8.0%)

Hudson Bay Capital Management LP

Value ($000) $5,559 (-34.5%) Shares 170,000 (-30.6%)

Jump Financial, LLC

Value ($000) $948 (-46.6%) Shares 29,000 (-43.5%)

VOLORIDGE INVESTMENT MANAGEMENT, LLC

Value ($000) $1,434 (-52.7%) Shares 43,856 (-49.9%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $10,157 (-17.7%) Shares 310,600 (-12.8%)

Quadrature Capital Ltd

Value ($000) $491 (-46.0%) Shares 15,006 (-42.8%)

Monaco Asset Management SAM

Value ($000) $1,063 (-8.5%) Shares 32,520 (-3.0%)

GOLDMAN SACHS GROUP INC

Value ($000) $364 (-84.1%) Shares 11,144 (-83.2%)

MARSHALL WACE, LLP

Value ($000) $366 (-72.5%) Shares 11,200 (-70.9%)

Aquatic Capital Management LLC

Value ($000) $448 (-26.1%) Shares 13,712 (-21.7%)

NORGES BANK

Value ($000) $2,943 (-12.4%) Shares 90,000 (-25.0%)

ROYAL BANK OF CANADA

Value ($000) $175 (-82.2%) Shares 5,355 (-81.2%)

CITIGROUP INC

Value ($000) $13 (-97.2%) Shares 404 (-97.1%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $535 (-31.2%) Shares 16,360 (-27.2%)

AMERICAN CENTURY COMPANIES INC

Value ($000) $874 (-8.6%) Shares 26,729 (-3.2%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $363 (-11.6%) Shares 11,098 (-6.4%)

QUADRANT CAPITAL GROUP LLC

Value ($000) $115 (-14.4%) Shares 3,520 (-9.3%)

EverSource Wealth Advisors, LLC

Value ($000) $1 (-90.2%) Shares 32 (-89.6%)

Institution	Prev Shares	Curr Shares	Change
Prosight Management, LP	1,150,000	1,074,112	-75,888 (-6.6%)
TANG CAPITAL MANAGEMENT LLC	4,151,194	3,921,219	-229,975 (-5.5%)
SEGALL BRYANT & HAMILL, LLC	487,196	448,096	-39,100 (-8.0%)
Hudson Bay Capital Management LP	245,000	170,000	-75,000 (-30.6%)
Jump Financial, LLC	51,300	29,000	-22,300 (-43.5%)
VOLORIDGE INVESTMENT MANAGEMENT, LLC	87,572	43,856	-43,716 (-49.9%)
RENAISSANCE TECHNOLOGIES LLC	356,200	310,600	-45,600 (-12.8%)
Quadrature Capital Ltd	26,245	15,006	-11,239 (-42.8%)
Monaco Asset Management SAM	33,536	32,520	-1,016 (-3.0%)
GOLDMAN SACHS GROUP INC	66,141	11,144	-54,997 (-83.2%)
MARSHALL WACE, LLP	38,460	11,200	-27,260 (-70.9%)
Aquatic Capital Management LLC	17,516	13,712	-3,804 (-21.7%)
NORGES BANK	120,000	90,000	-30,000 (-25.0%)
ROYAL BANK OF CANADA	28,429	5,355	-23,074 (-81.2%)
CITIGROUP INC	13,853	404	-13,449 (-97.1%)
TWO SIGMA INVESTMENTS, LP	22,459	16,360	-6,099 (-27.2%)
AMERICAN CENTURY COMPANIES INC	27,603	26,729	-874 (-3.2%)
BNP PARIBAS ARBITRAGE, SA	11,854	11,098	-756 (-6.4%)
QUADRANT CAPITAL GROUP LLC	3,880	3,520	-360 (-9.3%)
EverSource Wealth Advisors, LLC	309	32	-277 (-89.6%)

Exited Positions (16)

MATAURO, LLC

Value ($000) $1,647 Shares 47,536

SUVRETTA CAPITAL MANAGEMENT, LLC

Value ($000) $1,286 Shares 37,111

Empirical Financial Services, LLC d.b.a. Empirical Wealth Management

Value ($000) $605 Shares 17,469

Verition Fund Management LLC

Value ($000) $702 Shares 20,270

PRIMECAP MANAGEMENT CO/CA/

Value ($000) $1,749 Shares 50,500

Brinker Capital Investments, LLC

Value ($000) $252 Shares 7,261

Vanguard Personalized Indexing Management, LLC

Value ($000) $212 Shares 6,106

NATIONAL BANK OF CANADA /FI/

Value ($000) $494 Shares 14,281

JANE STREET GROUP, LLC

Value ($000) $313 Shares 9,049

Squarepoint Ops LLC

Value ($000) $211 Shares 6,099

PRINCIPAL SECURITIES, INC.

Value ($000) $6 Shares 184

Rockefeller Capital Management L.P.

Value ($000) $1 Shares 35

Physician Wealth Advisors, Inc.

Value ($000) $1 Shares 24

HRT FINANCIAL LP

Value ($000) $0 Shares 8,697

Ronald Blue Trust, Inc.

Value ($000) $0 Shares 10

MONTAG A & ASSOCIATES INC

Value ($000) $0 Shares 6

Institution	Prev Shares	Prev Value ($000)
MATAURO, LLC	47,536	$1,647
SUVRETTA CAPITAL MANAGEMENT, LLC	37,111	$1,286
Empirical Financial Services, LLC d.b.a. Empirical Wealth Management	17,469	$605
Verition Fund Management LLC	20,270	$702
PRIMECAP MANAGEMENT CO/CA/	50,500	$1,749
Brinker Capital Investments, LLC	7,261	$252
Vanguard Personalized Indexing Management, LLC	6,106	$212
NATIONAL BANK OF CANADA /FI/	14,281	$494
JANE STREET GROUP, LLC	9,049	$313
Squarepoint Ops LLC	6,099	$211
PRINCIPAL SECURITIES, INC.	184	$6
Rockefeller Capital Management L.P.	35	$1
Physician Wealth Advisors, Inc.	24	$1
HRT FINANCIAL LP	8,697	$0
Ronald Blue Trust, Inc.	10	$0
MONTAG A & ASSOCIATES INC	6	$0