| Sands Capital Ventures, LLC | 13,018,965 | $26,689 |
| Soleus Capital Management, L.P. | 10,875,000 | $22,294 |
| Fairmount Funds Management LLC | 8,625,000 | $17,681 |
| ADAR1 Capital Management, LLC | 8,063,949 | $16,531 |
| Trails Edge Capital Partners, LP | 6,178,124 | $12,665 |
| Blackstone Inc. | 5,938,276 | $12,173 |
| Siren, L.L.C. | 5,850,000 | $11,993 |
| PERCEPTIVE ADVISORS LLC | 5,421,568 | $11,114 |
| Commodore Capital LP | 5,397,488 | $11,065 |
| VANGUARD GROUP INC | 4,558,604 | $9,345 |
| Squadron Capital Management LLC | 4,225,000 | $8,661 |
| Nantahala Capital Management, LLC | 3,929,292 | $8,055 |
| Saturn V Capital Management LP | 3,856,799 | $7,906 |
| Spruce Street Capital LP | 3,581,603 | $7,342 |
| BlackRock, Inc. | 3,305,574 | $6,776 |
| Stonepine Capital Management, LLC | 2,348,147 | $4,814 |
| Integral Health Asset Management, LLC | 1,750,000 | $3,588 |
| Kalehua Capital Management LLC | 1,750,000 | $3,588 |
| AMERIPRISE FINANCIAL INC | 1,376,395 | $2,822 |
| CITADEL ADVISORS LLC | 1,243,630 | $2,549 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,128,239 | $2,313 |
| Exome Asset Management LLC | 600,000 | $1,230 |
| STATE STREET CORP | 554,849 | $1,137 |
| Seven Fleet Capital Management LP | 533,648 | $1,094 |
| NORTHERN TRUST CORP | 322,720 | $662 |
| MILLENNIUM MANAGEMENT LLC | 169,850 | $348 |
| BLAIR WILLIAM & CO/IL | 152,953 | $314 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 152,298 | $312 |
| Bank of New York Mellon Corp | 137,485 | $282 |
| JANE STREET GROUP, LLC | 116,003 | $238 |
| BARCLAYS PLC | 94,795 | $194 |
| UBS Group AG | 94,545 | $194 |
| Persistent Asset Partners Ltd | 93,430 | $192 |
| GOLDMAN SACHS GROUP INC | 85,267 | $175 |
| MORGAN STANLEY | 79,682 | $163 |
| Nuveen, LLC | 78,659 | $161 |
| WELLS FARGO & COMPANY/MN | 67,833 | $139 |
| FMR LLC | 57,374 | $118 |
| DEUTSCHE BANK AG\ | 54,909 | $113 |
| NEW YORK STATE COMMON RETIREMENT FUND | 47,900 | $98 |
| RHUMBLINE ADVISERS | 47,163 | $97 |
| BANK OF AMERICA CORP /DE/ | 46,411 | $95 |
| Invesco Ltd. | 32,262 | $66 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 30,606 | $0 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28,875 | $59 |
| CAXTON CORP | 28,453 | $58 |
| INTECH INVESTMENT MANAGEMENT LLC | 26,884 | $55 |
| JPMORGAN CHASE & CO | 24,849 | $51 |
| Virtu Financial LLC | 22,869 | $0 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 21,532 | $44 |
| XTX Topco Ltd | 20,298 | $42 |
| Police & Firemen's Retirement System of New Jersey | 17,638 | $36 |
| Scientech Research LLC | 15,977 | $33 |
| Voya Investment Management LLC | 13,146 | $27 |
| BNP PARIBAS ARBITRAGE, SA | 12,891 | $26 |
| Sanctuary Advisors, LLC | 12,539 | $26 |
| VICTORY CAPITAL MANAGEMENT INC | 11,400 | $23 |
| ProShare Advisors LLC | 11,046 | $23 |
| Russell Investments Group, Ltd. | 10,814 | $22 |
| Buckingham Strategic Partners | 10,719 | $22 |
| HRT FINANCIAL LP | 10,570 | $0 |
| ROYAL BANK OF CANADA | 6,653 | $14 |
| Tower Research Capital LLC (TRC) | 6,509 | $13 |
| Ameritas Investment Partners, Inc. | 6,174 | $13 |
| Legal & General Group Plc | 5,504 | $11 |
| Pinnacle Wealth Planning Services, Inc. | 5,400 | $11 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,715 | $8 |
| CITIGROUP INC | 3,286 | $7 |
| Sterling Capital Management LLC | 3,220 | $7 |
| AMALGAMATED BANK | 1,900 | $0 |
| PNC Financial Services Group, Inc. | 101 | $0 |
| CWM, LLC | 73 | $0 |
| EverSource Wealth Advisors, LLC | 4 | $0 |
| Allworth Financial LP | 1 | $0 |