IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Redmile Group, LLC's Holding History (CIK: 0001425738)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022

Shares 266,187 Value ($000) $10,054 Avg Close $42.06 Range $36.69 - $47.74

Q3 2022

Shares 407,659 Value ($000) $18,031 Avg Close $42.14 Range $35.95 - $48.82

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2022	266,187	$10,054	$42.06	$36.69 - $47.74
Q3 2022	407,659	$18,031	$42.14	$35.95 - $48.82