IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

DCF Advisers, LLC's Holding History (CIK: 0001802493)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 103,000 Value ($000) $8,148 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 108,413 Value ($000) $7,092 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 91,750 Value ($000) $3,625 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 95,000 Value ($000) $2,866 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 82,882 Value ($000) $2,898 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 39,500 Value ($000) $1,582 Avg Close $46.53 Range $39.48 - $52.34

Q2 2024

Shares 23,000 Value ($000) $1,096 Avg Close $41.01 Range $35.95 - $47.86

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	103,000	$8,148	$75.30	$64.93 - $83.61
Q3 2025	108,413	$7,092	$48.82	$39.72 - $65.55
Q2 2025	91,750	$3,625	$32.73	$23.95 - $40.61
Q1 2025	95,000	$2,866	$32.75	$29.61 - $35.48
Q4 2024	82,882	$2,898	$37.38	$33.33 - $40.58
Q3 2024	39,500	$1,582	$46.53	$39.48 - $52.34
Q2 2024	23,000	$1,096	$41.01	$35.95 - $47.86