IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Exome Asset Management LLC's Holding History (CIK: 0002011932)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 116,515 Value ($000) $9,218 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 131,016 Value ($000) $8,571 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 121,116 Value ($000) $4,785 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 135,616 Value ($000) $4,092 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 61,367 Value ($000) $2,145 Avg Close $37.38 Range $33.33 - $40.58

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	116,515	$9,218	$75.30	$64.93 - $83.61
Q3 2025	131,016	$8,571	$48.82	$39.72 - $65.55
Q2 2025	121,116	$4,785	$32.73	$23.95 - $40.61
Q1 2025	135,616	$4,092	$32.75	$29.61 - $35.48
Q4 2024	61,367	$2,145	$37.38	$33.33 - $40.58