Exome Asset Management LLC Quant / Systematic

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
WVE	WAVE LIFE SCIENCES LTD	421,488	$7,165	3.4%	$10.16	0.0%	SHS	Y95308105
ELV	ELEVANCE HEALTH INC FORMERLY	17,191	$6,026	2.9%	$336.70	0.0%	COM	036752103
JAZZ	JAZZ PHARMACEUTICALS PLC	26,494	$4,504	2.2%	$153.31	0.0%	SHS USD	G50871105
AGIO	AGIOS PHARMACEUTICALS INC	136,942	$3,728	1.8%	$35.08	0.0%	COM	00847X104
ELVN	ENLIVEN THERAPEUTICS INC	222,308	$3,424	1.6%	$19.92	0.0%	COM	29337E102
CELC	CELCUITY INC	34,289	$3,420	1.6%	$82.21	0.0%	COM	15102K100
APLS	APELLIS PHARMACEUTICALS INC	135,849	$3,413	1.6%	$23.46	0.0%	COM	03753U106
DXCM	DEXCOM INC	50,147	$3,328	1.6%	$64.65	0.0%	COM	252131107
VSTM	VERASTEM INC	401,743	$3,101	1.5%	$8.91	0.0%	COM NEW	92337C203
—	TRAVERE THERAPEUTICS INC	74,700	$2,854	1.4%	—	—	PUT	89422G957
IMCR	IMMUNOCORE HLDGS PLC	76,750	$2,664	1.3%	$34.71	—	ADS	45258D105
NXTC	NEXTCURE INC	165,000	$2,341	1.1%	$10.36	0.0%	COM NEW	65343E207
BLTE	BELITE BIO INC	14,328	$2,292	1.1%	$159.96	—	SPONSORED ADS	07782B104
IRWD	IRONWOOD PHARMACEUTICALS INC	648,532	$2,186	1.0%	$2.60	0.0%	COM CL A	46333X108
KPTI	KARYOPHARM THERAPEUTICS INC	295,541	$2,175	1.0%	$6.12	0.0%	COM NEW	48576U205
ADAG	ADAGENE INC	1,060,221	$2,004	1.0%	$1.89	—	ADS	005329107
UNH	UNITEDHEALTH GROUP INC	5,835	$1,926	0.9%	$337.21	0.0%	COM	91324P102
PALI	PALISADE BIO INC	758,203	$1,782	0.9%	$1.92	0.0%	COM	696389402
—	DISC MEDICINE INC	16,000	$1,271	0.6%	—	—	PUT	254604951
IKT	INHIBIKASE THERAPEUTICS INC	600,000	$1,230	0.6%	$1.59	0.0%	COM NEW	45719W205
IQV	IQVIA HLDGS INC	5,378	$1,212	0.6%	$217.58	0.0%	COM	46266C105
—	ULTRAGENYX PHARMACEUTICAL IN	35,200	$810	0.4%	—	—	CALL	90400D958
—	ALUMIS INC	53,200	$519	0.2%	—	—	PUT	022307952
—	ALDEYRA THERAPEUTICS INC	100,000	$518	0.2%	—	—	CALL	01438T906
RAPT	RAPT THERAPEUTICS INC	14,194	$481	0.2%	$31.06	0.0%	COM NEW	75382E208
—	SOLENO THERAPEUTICS INC	7,100	$328	0.2%	—	—	PUT	834203959

Increased Positions (5)

UHS UNIVERSAL HLTH SVCS INC 1.8%

Value ($000) $3,843 (+136.3%) Shares 17,628 (+121.6%) Est. Cost $202.45 Unrealized +9.1%

GKOS GLAUKOS CORP 1.7%

Value ($000) $3,553 (+60.5%) Shares 31,471 (+15.9%) Est. Cost $92.34 Unrealized +3.5%

UTHR UNITED THERAPEUTICS CORP DEL 1.8%

Value ($000) $3,745 (+34.4%) Shares 7,685 (+15.7%) Est. Cost $353.82 Unrealized +31.6%

UPB UPSTREAM BIO INC 0.8%

Value ($000) $1,761 (+80.1%) Shares 64,845 (+24.8%) Est. Cost $17.40 Unrealized +43.1%

WAY WAYSTAR HLDG CORP 1.1%

Value ($000) $2,259 (+27.0%) Shares 68,969 (+47.1%) Est. Cost $37.59 Unrealized -5.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
UHS	UNIVERSAL HLTH SVCS INC	17,628 (+121.6%)	$3,843 (+136.3%)	1.8%	$202.45	+9.1%	CL B	913903100
GKOS	GLAUKOS CORP	31,471 (+15.9%)	$3,553 (+60.5%)	1.7%	$92.34	+3.5%	COM	377322102
UTHR	UNITED THERAPEUTICS CORP DEL	7,685 (+15.7%)	$3,745 (+34.4%)	1.8%	$353.82	+31.6%	COM	91307C102
UPB	UPSTREAM BIO INC	64,845 (+24.8%)	$1,761 (+80.1%)	0.8%	$17.40	+43.1%	COM	91678A107
WAY	WAYSTAR HLDG CORP	68,969 (+47.1%)	$2,259 (+27.0%)	1.1%	$37.59	-5.2%	COM	946784105

Exited Positions (34)

— 89BIO INC 1.9%

Value ($000) $4,023 Shares 273,661 Est. Cost $8.43 Unrealized —

APGE APOGEE THERAPEUTICS INC 1.8%

Value ($000) $3,751 Shares 94,400 Est. Cost $38.18 Unrealized +65.0%

CVS CVS HEALTH CORP 1.6%

Value ($000) $3,287 Shares 43,600 Est. Cost $67.82 Unrealized +16.0%

SLNO SOLENO THERAPEUTICS INC 1.6%

Value ($000) $3,275 Shares 48,445 Est. Cost $54.95 Unrealized -0.2%

— AKERO THERAPEUTICS INC 1.3%

Value ($000) $2,781 Shares 58,579 Est. Cost $47.48 Unrealized —

PPH VANECK ETF TRUST 1.3%

Value ($000) $2,711 Shares 30,000 Est. Cost — Unrealized —

— TRAVERE THERAPEUTICS INC 1.3%

Value ($000) $2,629 Shares 110,000 Est. Cost — Unrealized —

GERN GERON CORP 1.2%

Value ($000) $2,546 Shares 1,858,354 Est. Cost $3.24 Unrealized -61.2%

CNTA CENTESSA PHARMACEUTICALS PLC 1.0%

Value ($000) $2,135 Shares 88,024 Est. Cost $11.66 Unrealized —

— NOVO-NORDISK A S 0.9%

Value ($000) $1,942 Shares 35,000 Est. Cost — Unrealized —

COR CENCORA INC 0.9%

Value ($000) $1,875 Shares 6,000 Est. Cost $293.50 Unrealized +16.1%

SNDX SYNDAX PHARMACEUTICALS INC 0.9%

Value ($000) $1,812 Shares 117,783 Est. Cost $16.95 Unrealized +2.9%

— SAREPTA THERAPEUTICS INC 0.8%

Value ($000) $1,764 Shares 2,000,000 Est. Cost $0.72 Unrealized —

— KARYOPHARM THERAPEUTICS INC 0.8%

Value ($000) $1,634 Shares 2,000,000 Est. Cost $0.76 Unrealized —

ORIC ORIC PHARMACEUTICALS INC 0.7%

Value ($000) $1,448 Shares 120,644 Est. Cost $10.52 Unrealized +9.4%

PRCT PROCEPT BIOROBOTICS CORP 0.7%

Value ($000) $1,424 Shares 39,900 Est. Cost $45.66 Unrealized -27.4%

INSP INSPIRE MED SYS INC 0.7%

Value ($000) $1,380 Shares 18,600 Est. Cost $101.25 Unrealized -5.5%

QURE UNIQURE NV 0.6%

Value ($000) $1,289 Shares 22,090 Est. Cost $18.16 Unrealized +112.5%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.6%

Value ($000) $1,277 Shares 178,084 Est. Cost $52.12 Unrealized -77.4%

AVTX AVALO THERAPEUTICS INC 0.6%

Value ($000) $1,271 Shares 100,036 Est. Cost $8.60 Unrealized +96.3%

— LIQUIDIA CORPORATION 0.6%

Value ($000) $1,205 Shares 53,000 Est. Cost — Unrealized —

— ARCTURUS THERAPEUTICS HLDGS 0.4%

Value ($000) $922 Shares 50,000 Est. Cost — Unrealized —

MBX MBX BIOSCIENCES INC 0.4%

Value ($000) $917 Shares 52,402 Est. Cost $10.57 Unrealized +129.5%

— MBX BIOSCIENCES INC 0.4%

Value ($000) $884 Shares 50,500 Est. Cost — Unrealized —

— COGENT BIOSCIENCES INC 0.3%

Value ($000) $646 Shares 45,000 Est. Cost — Unrealized —

— CENTESSA PHARMACEUTICALS PLC 0.3%

Value ($000) $606 Shares 25,000 Est. Cost — Unrealized —

— PRAXIS PRECISION MEDICINES I 0.3%

Value ($000) $530 Shares 10,000 Est. Cost — Unrealized —

— MBX BIOSCIENCES INC 0.3%

Value ($000) $525 Shares 30,000 Est. Cost — Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 0.2%

Value ($000) $427 Shares 20,000 Est. Cost — Unrealized —

— KARYOPHARM THERAPEUTICS INC 0.2%

Value ($000) $315 Shares 48,100 Est. Cost — Unrealized —

REPL REPLIMUNE GROUP INC 0.1%

Value ($000) $308 Shares 73,614 Est. Cost $11.40 Unrealized -25.4%

VTYX VENTYX BIOSCIENCES INC 0.1%

Value ($000) $188 Shares 60,600 Est. Cost $2.65 Unrealized +182.1%

IMUX IMMUNIC INC 0.1%

Value ($000) $153 Shares 173,900 Est. Cost $0.88 Unrealized -16.9%

ATYR ATYR PHARMA INC 0.0%

Value ($000) $29 Shares 40,000 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	89BIO INC	273,661	$4,023	1.9%	$8.43	—	—	282559103
APGE	APOGEE THERAPEUTICS INC	94,400	$3,751	1.8%	$38.18	+65.0%	—	03770N101
CVS	CVS HEALTH CORP	43,600	$3,287	1.6%	$67.82	+16.0%	—	126650100
SLNO	SOLENO THERAPEUTICS INC	48,445	$3,275	1.6%	$54.95	-0.2%	—	834203309
—	AKERO THERAPEUTICS INC	58,579	$2,781	1.3%	$47.48	—	—	00973Y108
PPH	VANECK ETF TRUST	30,000	$2,711	1.3%	—	—	CALL	92189F692
—	TRAVERE THERAPEUTICS INC	110,000	$2,629	1.3%	—	—	CALL	89422G907
GERN	GERON CORP	1,858,354	$2,546	1.2%	$3.24	-61.2%	—	374163103
CNTA	CENTESSA PHARMACEUTICALS PLC	88,024	$2,135	1.0%	$11.66	—	—	152309100
—	NOVO-NORDISK A S	35,000	$1,942	0.9%	—	—	CALL	670100905
COR	CENCORA INC	6,000	$1,875	0.9%	$293.50	+16.1%	—	03073E105
SNDX	SYNDAX PHARMACEUTICALS INC	117,783	$1,812	0.9%	$16.95	+2.9%	—	87164F105
—	SAREPTA THERAPEUTICS INC	2,000,000	$1,764	0.8%	$0.72	—	—	803607AD2
—	KARYOPHARM THERAPEUTICS INC	2,000,000	$1,634	0.8%	$0.76	—	—	48576UAA4
ORIC	ORIC PHARMACEUTICALS INC	120,644	$1,448	0.7%	$10.52	+9.4%	—	68622P109
PRCT	PROCEPT BIOROBOTICS CORP	39,900	$1,424	0.7%	$45.66	-27.4%	—	74276L105
INSP	INSPIRE MED SYS INC	18,600	$1,380	0.7%	$101.25	-5.5%	—	457730109
QURE	UNIQURE NV	22,090	$1,289	0.6%	$18.16	+112.5%	—	N90064101
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	178,084	$1,277	0.6%	$52.12	-77.4%	—	61559X104
AVTX	AVALO THERAPEUTICS INC	100,036	$1,271	0.6%	$8.60	+96.3%	—	05338F306
—	LIQUIDIA CORPORATION	53,000	$1,205	0.6%	—	—	PUT	53635D952
—	ARCTURUS THERAPEUTICS HLDGS	50,000	$922	0.4%	—	—	PUT	03969T959
MBX	MBX BIOSCIENCES INC	52,402	$917	0.4%	$10.57	+129.5%	—	55287L101
—	MBX BIOSCIENCES INC	50,500	$884	0.4%	—	—	PUT	55287L951
—	COGENT BIOSCIENCES INC	45,000	$646	0.3%	—	—	CALL	19240Q901
—	CENTESSA PHARMACEUTICALS PLC	25,000	$606	0.3%	—	—	PUT	152309950
—	PRAXIS PRECISION MEDICINES I	10,000	$530	0.3%	—	—	CALL	74006W907
—	MBX BIOSCIENCES INC	30,000	$525	0.3%	—	—	CALL	55287L901
ACAD	ACADIA PHARMACEUTICALS INC	20,000	$427	0.2%	—	—	PUT	004225108
—	KARYOPHARM THERAPEUTICS INC	48,100	$315	0.2%	—	—	PUT	48576U955
REPL	REPLIMUNE GROUP INC	73,614	$308	0.1%	$11.40	-25.4%	—	76029N106
VTYX	VENTYX BIOSCIENCES INC	60,600	$188	0.1%	$2.65	+182.1%	—	92332V107
IMUX	IMMUNIC INC	173,900	$153	0.1%	$0.88	-16.9%	—	4525EP101
ATYR	ATYR PHARMA INC	40,000	$29	0.0%	—	—	CALL	002120202

Decreased Positions (15)

PRAX PRAXIS PRECISION MEDICINES I 8.2%

Value ($000) $17,131 (+216.9%) Shares 58,122 (-43.0%) Est. Cost $42.47 Unrealized +338.5%

COGT COGENT BIOSCIENCES INC 5.2%

Value ($000) $10,854 (+70.4%) Shares 305,568 (-31.1%) Est. Cost $7.84 Unrealized +258.6%

NBP NOVABRIDGE BIOSCIENCES 1.0%

Value ($000) $1,988 (-63.5%) Shares 499,587 (-65.3%) Est. Cost $3.78 Unrealized —

THC TENET HEALTHCARE CORP 0.6%

Value ($000) $1,209 (-67.1%) Shares 6,084 (-66.4%) Est. Cost $150.53 Unrealized +34.3%

CRBP CORBUS PHARMACEUTICALS HLDGS 0.5%

Value ($000) $1,136 (-61.0%) Shares 139,543 (-39.3%) Est. Cost $8.83 Unrealized +39.8%

VERA VERA THERAPEUTICS INC 3.0%

Value ($000) $6,299 (+38.9%) Shares 124,391 (-20.3%) Est. Cost $22.81 Unrealized +55.7%

LQDA LIQUIDIA CORPORATION 1.5%

Value ($000) $3,144 (+46.7%) Shares 91,148 (-3.3%) Est. Cost $20.19 Unrealized +41.0%

BBIO BRIDGEBIO PHARMA INC 3.0%

Value ($000) $6,175 (-10.7%) Shares 80,723 (-39.3%) Est. Cost $27.07 Unrealized +142.4%

IONS IONIS PHARMACEUTICALS INC 4.4%

Value ($000) $9,218 (+7.5%) Shares 116,515 (-11.1%) Est. Cost $35.90 Unrealized +109.7%

TVTX TRAVERE THERAPEUTICS INC 1.6%

Value ($000) $3,403 (-9.3%) Shares 89,052 (-43.2%) Est. Cost $19.42 Unrealized +67.4%

IRON DISC MEDICINE INC 1.8%

Value ($000) $3,712 (-8.4%) Shares 46,743 (-23.8%) Est. Cost $36.21 Unrealized +133.3%

EWTX EDGEWISE THERAPEUTICS INC 1.2%

Value ($000) $2,483 (-11.7%) Shares 100,046 (-42.3%) Est. Cost $17.91 Unrealized +12.1%

ARWR ARROWHEAD PHARMACEUTICALS IN 1.6%

Value ($000) $3,303 (-8.4%) Shares 49,758 (-52.4%) Est. Cost $21.98 Unrealized +122.9%

FULC FULCRUM THERAPEUTICS INC 0.5%

Value ($000) $1,041 (+14.5%) Shares 92,055 (-6.8%) Est. Cost $3.68 Unrealized +176.6%

CYTK CYTOKINETICS INC 3.8%

Value ($000) $7,927 (+1.3%) Shares 124,749 (-12.4%) Est. Cost $48.43 Unrealized +28.4%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
PRAX	PRAXIS PRECISION MEDICINES I	58,122 (-43.0%)	$17,131 (+216.9%)	8.2%	$42.47	+338.5%	COM NEW	74006W207
COGT	COGENT BIOSCIENCES INC	305,568 (-31.1%)	$10,854 (+70.4%)	5.2%	$7.84	+258.6%	COM	19240Q201
NBP	NOVABRIDGE BIOSCIENCES	499,587 (-65.3%)	$1,988 (-63.5%)	1.0%	$3.78	—	SPONSORED ADS	44975P103
THC	TENET HEALTHCARE CORP	6,084 (-66.4%)	$1,209 (-67.1%)	0.6%	$150.53	+34.3%	COM NEW	88033G407
CRBP	CORBUS PHARMACEUTICALS HLDGS	139,543 (-39.3%)	$1,136 (-61.0%)	0.5%	$8.83	+39.8%	COM NEW	21833P301
VERA	VERA THERAPEUTICS INC	124,391 (-20.3%)	$6,299 (+38.9%)	3.0%	$22.81	+55.7%	CL A	92337R101
LQDA	LIQUIDIA CORPORATION	91,148 (-3.3%)	$3,144 (+46.7%)	1.5%	$20.19	+41.0%	COM NEW	53635D202
BBIO	BRIDGEBIO PHARMA INC	80,723 (-39.3%)	$6,175 (-10.7%)	3.0%	$27.07	+142.4%	COM	10806X102
IONS	IONIS PHARMACEUTICALS INC	116,515 (-11.1%)	$9,218 (+7.5%)	4.4%	$35.90	+109.7%	COM	462222100
TVTX	TRAVERE THERAPEUTICS INC	89,052 (-43.2%)	$3,403 (-9.3%)	1.6%	$19.42	+67.4%	COM	89422G107
IRON	DISC MEDICINE INC	46,743 (-23.8%)	$3,712 (-8.4%)	1.8%	$36.21	+133.3%	COM	254604101
EWTX	EDGEWISE THERAPEUTICS INC	100,046 (-42.3%)	$2,483 (-11.7%)	1.2%	$17.91	+12.1%	COM	28036F105
ARWR	ARROWHEAD PHARMACEUTICALS IN	49,758 (-52.4%)	$3,303 (-8.4%)	1.6%	$21.98	+122.9%	COM	04280A100
FULC	FULCRUM THERAPEUTICS INC	92,055 (-6.8%)	$1,041 (+14.5%)	0.5%	$3.68	+176.6%	COM	359616109
CYTK	CYTOKINETICS INC	124,749 (-12.4%)	$7,927 (+1.3%)	3.8%	$48.43	+28.4%	COM NEW	23282W605

Unchanged Positions (14)

GH GUARDANT HEALTH INC 4.8%

Value ($000) $10,028 Shares 98,182 Est. Cost $24.57 Unrealized +264.2%

LLY ELI LILLY & CO 4.0%

Value ($000) $8,438 Shares 7,852 Est. Cost $656.19 Unrealized +45.6%

ALMS ALUMIS INC 1.4%

Value ($000) $2,852 Shares 292,250 Est. Cost $4.12 Unrealized +69.5%

IMVT IMMUNOVANT INC 1.9%

Value ($000) $4,032 Shares 158,622 Est. Cost $16.19 Unrealized +37.7%

NTRA NATERA INC 2.0%

Value ($000) $4,273 Shares 18,650 Est. Cost $60.94 Unrealized +242.3%

AZN ASTRAZENECA PLC 2.5%

Value ($000) $5,261 Shares 28,362 Est. Cost $150.54 Unrealized —

CTMX CYTOMX THERAPEUTICS INC 1.5%

Value ($000) $3,175 Shares 745,305 Est. Cost $2.25 Unrealized +68.7%

ISRG INTUITIVE SURGICAL INC 1.7%

Value ($000) $3,601 Shares 6,358 Est. Cost $322.19 Unrealized +65.2%

TXG 10X GENOMICS INC 1.3%

Value ($000) $2,669 Shares 163,658 Est. Cost $9.12 Unrealized +65.7%

PEN PENUMBRA INC 1.3%

Value ($000) $2,798 Shares 9,000 Est. Cost $227.37 Unrealized +21.5%

ESTA ESTABLISHMENT LABS HLDGS INC 0.5%

Value ($000) $955 Shares 13,100 Est. Cost $50.73 Unrealized +19.0%

GOSS GOSSAMER BIO INC 0.7%

Value ($000) $1,400 Shares 451,699 Est. Cost $0.81 Unrealized +252.0%

— PRECIGEN INC 0.2%

Value ($000) $418 Shares 100,000 Est. Cost — Unrealized —

ABUS ARBUTUS BIOPHARMA CORP 0.2%

Value ($000) $363 Shares 75,484 Est. Cost $3.32 Unrealized +35.4%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
GH	GUARDANT HEALTH INC	98,182	$10,028	4.8%	$24.57	+264.2%	COM	40131M109
LLY	ELI LILLY & CO	7,852	$8,438	4.0%	$656.19	+45.6%	COM	532457108
ALMS	ALUMIS INC	292,250	$2,852	1.4%	$4.12	+69.5%	COM	022307102
IMVT	IMMUNOVANT INC	158,622	$4,032	1.9%	$16.19	+37.7%	COM	45258J102
NTRA	NATERA INC	18,650	$4,273	2.0%	$60.94	+242.3%	COM	632307104
AZN	ASTRAZENECA PLC	28,362	$5,261	2.5%	$150.54	—	SPONSORED ADR	046353108
CTMX	CYTOMX THERAPEUTICS INC	745,305	$3,175	1.5%	$2.25	+68.7%	COM	23284F105
ISRG	INTUITIVE SURGICAL INC	6,358	$3,601	1.7%	$322.19	+65.2%	COM NEW	46120E602
TXG	10X GENOMICS INC	163,658	$2,669	1.3%	$9.12	+65.7%	CL A COM	88025U109
PEN	PENUMBRA INC	9,000	$2,798	1.3%	$227.37	+21.5%	COM	70975L107
ESTA	ESTABLISHMENT LABS HLDGS INC	13,100	$955	0.5%	$50.73	+19.0%	COM	G31249108
GOSS	GOSSAMER BIO INC	451,699	$1,400	0.7%	$0.81	+252.0%	COM	38341P102
—	PRECIGEN INC	100,000	$418	0.2%	—	—	PUT	74017N955
ABUS	ARBUTUS BIOPHARMA CORP	75,484	$363	0.2%	$3.32	+35.4%	COM	03879J100