KARYOPHARM THERAPEUTICS INC

Ticker: KPTI CUSIP: 48576U205 Class: 0

ROYAL BANK OF CANADA's Holding History (CIK: 0001000275)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 58,000 Value ($000) $427 Avg Close $6.12 Range $4.51 - $7.70

Q3 2025

Shares 6,734 Value ($000) $44 Avg Close $5.38 Range $3.65 - $8.15

Q2 2025

Shares 7,429 Value ($000) $32 Avg Close $4.91 Range $3.51 - $7.90

Q1 2025

Shares 1,459 Value ($000) $5 Avg Close $8.54 Range $3.73 - $12.45

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	58,000	$427	$6.12	$4.51 - $7.70
Q3 2025	6,734	$44	$5.38	$3.65 - $8.15
Q2 2025	7,429	$32	$4.91	$3.51 - $7.90
Q1 2025	1,459	$5	$8.54	$3.73 - $12.45