KARYOPHARM THERAPEUTICS INC

Ticker: KPTI CUSIP: 48576U205 Class: 0

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 59,914 Value ($000) $441 Avg Close $6.12 Range $4.51 - $7.70

Q3 2025

Shares 64,714 Value ($000) $423 Avg Close $5.38 Range $3.65 - $8.15

Q2 2025

Shares 65,814 Value ($000) $284 Avg Close $4.91 Range $3.51 - $7.90

Q1 2025

Shares 61,214 Value ($000) $229 Avg Close $8.54 Range $3.73 - $12.45

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	59,914	$441	$6.12	$4.51 - $7.70
Q3 2025	64,714	$423	$5.38	$3.65 - $8.15
Q2 2025	65,814	$284	$4.91	$3.51 - $7.90
Q1 2025	61,214	$229	$8.54	$3.73 - $12.45