KRYSTAL BIOTECH INC

Ticker: KRYS CUSIP: 501147102 Class: Common Stock

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,300 Value ($000) $814 Avg Close $210.47 Range $175.85 - $265.92

Q2 2025

Shares 89,800 Value ($000) $12,344 Avg Close $146.88 Range $122.80 - $182.16

Q1 2025

Shares 11,200 Value ($000) $2,019 Avg Close $168.21 Range $141.72 - $197.94

Q4 2024

Shares 10,900 Value ($000) $1,708 Avg Close $177.39 Range $154.16 - $207.84

Q3 2024

Shares 14,400 Value ($000) $2,621 Avg Close $192.81 Range $164.81 - $219.34

Q1 2024

Shares 24,700 Value ($000) $4 Avg Close $138.91 Range $107.50 - $189.97

Q3 2021

Shares 33,300 Value ($000) $1,739 Avg Close $59.20 Range $51.04 - $72.55

Q3 2020

Shares 19,600 Value ($000) $844 Avg Close $43.43 Range $37.68 - $48.80

Q2 2020

Shares 61,400 Value ($000) $2,543 Avg Close $48.11 Range $35.33 - $61.86

Q1 2020

Shares 6,000 Value ($000) $259 Avg Close $52.30 Range $33.09 - $66.85

Q1 2019

Shares 30,800 Value ($000) $1,013 Avg Close $23.57 Range $18.50 - $33.12

Q4 2018

Shares 41,900 Value ($000) $871 Avg Close $20.94 Range $14.30 - $28.75

Q3 2018

Shares 50,700 Value ($000) $891 Avg Close $16.78 Range $14.28 - $21.17

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,300	$814	$210.47	$175.85 - $265.92
Q2 2025	89,800	$12,344	$146.88	$122.80 - $182.16
Q1 2025	11,200	$2,019	$168.21	$141.72 - $197.94
Q4 2024	10,900	$1,708	$177.39	$154.16 - $207.84
Q3 2024	14,400	$2,621	$192.81	$164.81 - $219.34
Q1 2024	24,700	$4	$138.91	$107.50 - $189.97
Q3 2021	33,300	$1,739	$59.20	$51.04 - $72.55
Q3 2020	19,600	$844	$43.43	$37.68 - $48.80
Q2 2020	61,400	$2,543	$48.11	$35.33 - $61.86
Q1 2020	6,000	$259	$52.30	$33.09 - $66.85
Q1 2019	30,800	$1,013	$23.57	$18.50 - $33.12
Q4 2018	41,900	$871	$20.94	$14.30 - $28.75
Q3 2018	50,700	$891	$16.78	$14.28 - $21.17